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Colorado Rockies vs San Francisco Giants Prediction 9/27/2025 Today’s MLB Picks

Sep 16, 2025; Phoenix, Arizona, USA; San Francisco Giants first baseman Wilmer Flores against the Arizona Diamondbacks at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

Sep 16, 2025; Phoenix, Arizona, USA; San Francisco Giants first baseman Wilmer Flores against the Arizona Diamondbacks at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

Colorado (43-117) vs San Francisco (79-81)

September 27, 2025 at 04:05 PM EDT

The Line: Betting Odds: San Francisco -235 — Over/Under: +8

(Get latest betting odds)

The Colorado Rockies and the San Francisco Giants meet Saturday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Rockies vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Colorado Rockies will send out Kyle Freeland here and Freeland is 5-16 with a 5.00 ERA and 120 strikeouts this season. In his last five starts against the Giants, Freeland is 1-2 with a 6.55 ERA and 22 strikeouts. Justin Verlander will start this one for the Giants and is 3-11 with a 3.88 ERA and 130 strikeouts this season. In his last five starts against the Rockies, Verlander is 2-1 with a 3.73 ERA and 31 strikeouts. 

Colorado Rockies Recap

The Colorado Rockies come into this game looking to bounce back from their series-opening 6-3 loss at the hands of the Giants to fall to 43-117 this season.

Rockies Trying To Salvage Something From Lose Season

Hunter Goodman leads the Rockies with 147 hits including 27 doubles, 5 triples, 30 home runs and 90 RBIs while Michael Toglia has 58 hits with 15 doubles, 11 home runs and 32 RBIs but also has 132 strikeouts. Kyle Farmer has 14 doubles while Jordan Beck has 15 home runs, 27 doubles, 52 RBIs, 5 triples and 19 stolen bases. Brenton Doyle has 113 hits with 21 doubles, 14 home runs, 56 RBIs and 17 stolen bases. Mickey Moniak has 117 hits with 20 doubles, 8 triples and 24 home runs with 68 RBIs. Tyler Freeman also has 106 hits with 20 doubles and 18 stolen bases so far this season.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their win over Colorado from Friday’s matchup to sit at 79-81 on the year.

Giants Looking To Finish Season On A Run

Jung Hoo Lee has 143 hits including a team-high 31 doubles along with 11 triples, 8 home runs and 53 RBIs with 10 stolen bases while Heliot Ramos has 157 hits with 24 doubles, 20 home runs and 66 RBIs. Wilmer Flores also has 16 home runs and 71 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 103 hits with 21 home runs and 61 RBIs along with 22 doubles and Willy Adames has 131 hits with 22 doubles, 28 home runs and 84 RBIs of his own this season. 

Colorado Rockies @ San Francisco Giants Betting Trends: September 27, 2025


  • Probable Starting Pitcher: Justin Verlander      Record this season: 3-11      ERA: 3.88
  • Home Record: 2-7
  • Last 5 against Rockies: 2-1

Why the San Francisco Giants will win

  • The Rockies have lost each of their last 14 games at Oracle Park against teams that held a losing record.
  • The Giants have won each of their last 12 home games against the Rockies following a win.
  • The Rockies have failed to cover the run line in 14 of their last 15 games against National League opponents after playing the previous day.
  • The Giants have covered the run line in 10 of their last 11 home games against the Rockies following a win.
  • The Rockies have trailed after 5 innings in each of their last 14 games at Oracle Park against opponents that held a losing record.
  • The Rockies have trailed after 3 innings in each of their last seven games against NL West opponents.
  • The Rockies have lost the first inning in each of their last six road games against NL West opponents that held a losing record.

  • Probable Starting Pitcher: Kyle Freeland      Record this season: 5-16      ERA: 5.00
  • Road Record: 2-9
  • Last 5 against Giants: 1-2

Why the Colorado Rockies will win

  • The Giants have lost each of their last four games as favorites after playing the previous day.
  • The underdogs have won four of the Giants’ last five games.
  • The Giants have failed to cover the run line in each of their last seven Saturday games as favorites against National League opponents.
  • The underdogs have covered the run line in four of the Giants’ last five games.
  • The Giants have trailed after 3 innings in three of their last four home day games.
  • The Giants have trailed after 5 innings in each of their last five day games at Oracle Park against NL West opponents.

Total Runs Facts

  • Each of the Rockies’ last six games against National League opponents have gone OVER the total runs line.
  • Eight of the Giants’ last nine games as home favorites have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last six games as favorites.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Rockies’ last four games against NL West opponents.

San Francisco Giants Player Prop Facts

  • Heliot Ramos has hit a home run in each of the Giants’ last three games as favorites.
  • Justin Verlander has recorded five or more strikeouts in 41 of his last 49 home appearances against opponents that held a losing record.
  • Wilmer Flores has recorded at least one hit in each of his last nine appearances against the Rockies.

Colorado Rockies Player Prop Facts

  • Brenton Doyle has hit a home run in three of his last five road appearances against opponents that held a losing record.
  • Ezequiel Tovar has recorded at least one Double in four of the Rockies’ last five day games against NL West opponents that held a losing record.
  • Kyle Freeland has recorded four or more strikeouts in seven of his last eight appearances in day games against NL teams that held a losing record.
  • Ezequiel Tovar has recorded at least one hit in each of his last 10 appearances against the Giants.

Matchup/League Facts

  • The Giants rank 1st in the league for home runs allowed this season (139).
  • The Giants rank 29th in the league for steals this season (68).
  • The Rockies rank 30th in the league for on-base percentage this season (.294).
  • The Rockies rank 30th in the league for walks this season (390).

Colorado Rockies vs. San Francisco Giants Prediction

I’m on the Rockies here. I know it’s still expecting something from the worst team in baseball, but the thing is that I have a hard time laying this kind of price with Justin Verlander and the Giants who still have a horrid win percentage in his team starts this season. I just think it’s worth taking a shot on Colorado and hte hefty plus money here. Give me the Rockies.

Chris Ruffolo's Pick: Colorado +195

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