Cleveland Guardians vs St. Louis Cardinals Prediction 4/13/2026 Today’s MLB Picks

The Cleveland Guardians and the St. Louis Cardinals meet Monday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Cleveland Guardians will send Gavin Williams for the start here and Williams is 1-1 with a 2.04 ERA and 25 strikeouts this season. This will be Williams’ second career start against St. Louis. The St. Louis Cardinals will trot out Matthew Liberatore here and Liberatore is 0-0 with a 3.38 ERA and 10 strikeouts this season. In his career, Liberatore is 1-1 with a 3.27 ERA and 7 strikeouts against Cleveland.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to bounce back from a 13-1 blowout loss to Atlanta in Sunday’s series finale to sit at 9-7 this season. After this series, the Guardians will head home for a series against the Baltimore Orioles.

Guardians Alternate Wins & Losses In 4 Straight

Chase DeLauter has 15 hits with 4 doubles, a team-high 5 home runs and 12 RBIs while Steven Kwan has a 14 hits with 2 doubles, a home run and 4 RBIs and Jose Ramirez has 11 hits with 3 doubles, 2 home runs and 7 RBIs this season. Brayan Rocchio has also added 8 hits with a double, a home run and 6 RBIs this season while Angel Martinez has 13 hits with 3 doubles, a homer and 6 RBIs and Rhys Hoskins has added 9 hits with 5 doubles, a home run and 5 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from a 9-3 loss at the hands of Boston last time out to sit at 8-7 this season. After this series, the Cardinals will head on the road for a series against the Houston Astros.

Cardinals Lose Back-To-Back Games

Jordan Walker leads the Cardinals with 18 hits, 2 doubles, 7 home runs and 14 RBIs while Alec Burleson has 14 hits with a pair of doubles, a pair of home runs and 11 RBIs. JJ Wetherholt has 12 hits with a home run and 5 RBIs while Ivan Herrera has 10 hits with 3 doubles and 6 RBIs. Nolan Gorman has 9 hits with 2 home runs and 9 RBIs this season.

Cleveland Guardians @ St. Louis Cardinals Betting Trends: April 13, 2026

• Probable Starting Pitcher: Matthew Liberatore      Record this season: 0-0      ERA: 3.38
• Home Record: 0-0
• Last 5 against Guardians: 1-1

Why the St. Louis Cardinals will win

• The Guardians have lost each of their last eight night games against NL Central opponents.
• The Cardinals have won six of their last seven games as underdogs against AL Central opponents following a loss.
• The Guardians have failed to cover the run line in seven of their last eight games as favorites.
• The Cardinals have covered the run line in six of their last seven games as underdogs against AL Central opponents following a loss.
• The Cardinals have led after 3 innings in each of their last three games against the Guardians.
• The Guardians have trailed after 5 innings in five of their last six night games against NL Central opponents.

• Probable Starting Pitcher: Gavin Williams      Record this season: 1-1      ERA: 2.04
• Road Record: 1-1
• Last 5 against Cardinals: 0-0

Why the Cleveland Guardians will win

• The Guardians have won each of their last nine games following a loss.
• The Cardinals have lost each of their last seven home games against American League opponents that held a winning record.
• The Guardians have covered the run line in each of their last eight road games against National League opponents following a loss.
• The Cardinals have failed to cover the run line in nine of their last 10 home games against American League opponents that held a winning record.
• The Cardinals have lost the first inning in four of their last five home games against AL Central opponents.
• The Cardinals have trailed after 5 innings in 10 of their last 11 home games against American League opponents that held a winning record.

Total Runs Facts

• Six of the Cardinals’ last seven games as underdogs against the Guardians have gone OVER the total runs line.
• Five of the Guardians’ last six road games against NL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last eight road games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last six night games between the Guardians and Cardinals.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in two of the Cardinals’ last three night games against AL Central opponents that held a winning record.
• Lars Nootbaar has recorded at least one hit in each of his last seven appearances in night games against teams that held a winning record.
• Jordan Walker ranks 1st in the league in Home Runs (7) this season.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in each of the Guardians’ last two games as road favorites against the Cardinals.
• Steven Kwan has recorded two hits in each of the Guardians’ last three games as favorites against NL opponents.
• Chase DeLauter ranks T4th in the league in Home Runs (5) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for strikeouts this season (91).
• The Cardinals rank 30th in the league for opponent batting average this season (.266).
• The Guardians rank 2nd in the league for strikeouts this season (160).
• The Guardians rank T4th in the league for doubles this season (31).

Cleveland Guardians vs. St. Louis Cardinals Prediction

I’m on the Cardinals in this one. I get the case to be made for the Guardians, but Cleveland hasn’t been a team I’ve gone out of my way to trust against lefties this year and they’re coming off of the Sunday night debacle against the Braves. St. Louis has a solid lineup and while Gavin Williams is a decent option, I still think that the Cardinals can get to him and do enough for a series opening win here. Give me St. Louis.

Chris Ruffolo's Pick: St. Louis +105