Cleveland Guardians vs Seattle Mariners Prediction 3/28/2026 Today’s MLB Picks

The Cleveland Guardians and the Seattle Mariners meet Saturday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Seattle Mariners prediction.

Starting Pitching Matchup

The Cleveland Guardians will start Joey Cantillo here and Cantillo was 5-3 with a 3.21 ERA and 108 strikeouts last season. This will be Cantillo’s first career start against the Mariners. The Seattle Mariners will start Bryan Woo here and Woo was 15-7 with a 2.94 ERA and 198 strikeouts last season. This will be Woo’s second career start against Cleveland.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to bounce back from their 5-1 loss at the hands of the Mariners on Friday to fall to 1-1 on the year. After this series, the Guardians will head on the road to take on the defending champion Dodgers.

Guardians Looking To Restore Series Lead

Chase DeLauter leads the Guardians with 4 hits including a team-high 3 home runs and 3 RBIs while Rhys Hoskins has added 3 hits with a double and Brayan Rochio has 2 hits with a double and 2 RBIs. Steven Kwan has a pair of hits as well and Daniel Schneemann has a double while Kyle Manzardo, Bo Naylor and Gabriel Arias all have base knocks as well this season.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to add on to their win over the Guardians from Friday to get their first win of the season. After this set, Seattle will take on the New York Yankees in a series at home.

Mariners Looking For Back-To-Back Wins

Luke Raley leads the Mariners with a pair of hits coming in the form of 2 home runs and 3 RBIs while Dominic Canzone has a pair of solo home runs as well and Brendan Donovan has 2 hits with a double and a home run. Cole Young’s chipped in a home run and 3 RBIs as well while Randy Arozarena has a double and Leo Rivas has a triple this season.

Cleveland Guardians @ Seattle Mariners Betting Trends: March 28, 2026

• Probable Starting Pitcher: Bryan Woo      Record this season: –      ERA: –
• Home Record: –
• Last 5 against Guardians: 0-1

Why the Seattle Mariners will win

• The Mariners have won 10 of their last 11 home games against American League opponents following a home win.
• The Guardians have lost eight of their last nine games against AL West opponents following a road loss.
• The Guardians have failed to cover the run line in six of their last seven games after playing the previous day.
• The Mariners have covered the run line in five of their last six home games against American League opponents after playing the previous day.
• The Mariners have led after 3 innings in four of their last five games against AL Central opponents.
• The Mariners have led after 5 innings in four of their last five night games against AL Central opponents.

• Probable Starting Pitcher: Joey Cantillo      Record this season: –      ERA: –
• Road Record: –
• Last 5 against Mariners: –

Why the Cleveland Guardians will win

• The Guardians have won eight of their last nine games as road underdogs.
• The Mariners have lost six of their last seven games as home favorites.
• The Guardians have covered the run line in 12 of their last 13 games as underdogs.
• The Mariners have failed to cover the run line in each of their last four night games against the Guardians at T-Mobile Park following a win.
• The Mariners have trailed after 3 innings in three of their last four games as favorites.
• The Guardians have won the first inning in three of their last four games against AL West opponents.
• The Guardians have led after 5 innings in six of their last eight road night games.

Total Runs Facts

• Eight of the Guardians’ last nine road games after playing the previous day have gone UNDER the total runs line.
• Five of the Mariners’ last six games as favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Guardians’ last nine games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the last five night games between the Guardians and Mariners.

Seattle Mariners Player Prop Facts

• Brendan Donovan has recorded at least one Double in three of his last four appearances.
• Brendan Donovan has recorded at least one hit in 11 of his last 12 appearances in night games.
• Luke Raley has hit a home run in each of the Mariners’ last two games.
• Cal Raleigh ranked 1st in the league in Home Runs (60) last season.

Cleveland Guardians Player Prop Facts

• Rhys Hoskins has hit a home run in three of his four previous road appearances against the Mariners after playing the previous day.
• Rhys Hoskins has recorded a Double in three of his last four appearances with his team as an underdog against AL opponents.
• Rhys Hoskins has recorded at least one hit in each of his last eight Saturday appearances with his team as an underdog.
• Jose Ramirez ranked T2nd in the league in Steals (44) last season.

Matchup/League Facts

• The Mariners ranked 29th in the league for doubles last season (234).
• The Mariners ranked T29th in the league for triples last season (9).
• The Guardians ranked 30th in the league for hits last season (1199).
• The Guardians ranked 29th in the league for batting average last season (.226).

Cleveland Guardians vs. Seattle Mariners Prediction

I’m on the under here. I think this game is a bonafide pitcher’s duel, and one that can come down to the bullpens. You can take the first five innings under if you don’t want to deal with bullpen hijinks, but Bryan Woo was one of the best arms the Mariners had and Joey Cantillo is a lefty facing a Seattle lineup that wasn’t anything special against Southpaws last year. Give me the under.

Chris Ruffolo's Pick: Under 7