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Cleveland Guardians vs Pittsburgh Pirates Prediction 4/20/25 MLB Picks

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Pittsburgh Pirates (8-14) vs Cleveland Guardians (11-9)

Game Info: Sunday, April 20, 2025 at 1:35 pm (PNC Park)

The Line: Betting Odds: Pittsburgh Pirates -115 / Cleveland Guardians -105 — Over/Under: 8

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The Cleveland Guardians and the Pittsburgh Pirates meet Sunday in MLB action from PNC Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. Pittsburgh Pirates prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Logan Allen for the start here and Allen is 1-1 with a 2.30 ERA and 11 strikeouts this season. This will be Allen’s second career start against the Pirates. The Pittsburgh Pirates will start Mitch Keller here and Keller is 1-2 with a 4.30 ERA and 17 strikeouts this season. In his career, Keller is 0-2 with a 6.61 ERA and 11 strikeouts against the Guardians.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to add on to their 3-0 win over the Pirates in Saturday’s matchup to improve to 11-9 on the year. After this series, the Guardians will head home to start a series with the New York Yankees.

Guardians Looking To Complete The Sweep

Steven Kwan leads the Guardians with 26 hits as part of a .329 batting average and 3 home runs, 2 doubles and 12 RBIs. Kyle Manzardo has 12 hits with 2 doubles, a triple, 5 home runs and a team-high 13 RBIs as well this year. Nolan Jones and Jose Ramirez each have a team-high 4 doubles while Gabriel Arias has a team-high 20 strikeouts and Manzardo has 19 strikeouts so far this season. Arias has also added 4 home runs and 10 RBIs and Jose Ramirez has chipped in 4 home runs and 9 RBIs.

Why the Cleveland Guardians will win

Cleveland Guardians Player Prop Facts

Pittsburgh Pirates Recap

The Pittsburgh Pirates come into this game looking to bounce back after falling short in Saturday’s matchup to drop to 8-14 on the year. After this series, the Pirates will head back on the road for a series against the Los Angeles Angels.

Pirates Looking To Avoid Being Swept

Bryan Reynolds has a team-high 19 hits with 4 doubles, 3 home runs and 10 RBIs while also leading the Pirates with 32 strikeouts so far this season. Oneil Cruz has posted a team-high 5 home runs and 11 RBIs with 10 stolen bases while Isiah Kiner-Falefa has 18 hits with 5 stolen bases. Emmanuel Valdez also has a pair of triples as well this season.

Why the Pittsburgh Pirates will win

Pittsburgh Pirates Player Prop Facts

Total Runs Facts

Cleveland Guardians vs. Pittsburgh Pirates Prediction

I’m on the Guardians here. I get the case to be made for the Pirates at home, but the best shot Pittsburgh had a winning a game in this series came with their ace on the mound when Paul Skenes started on Saturday and once again, the Pirates offense stalled and was non-existent. The Guardians have had their own share of ups and downs this season, but I trust the Guardians at the plate as they’re a disciplined team that don’t have bad at-bats often, and from a talent perspective, the Guardians have one of the best bullpens in baseball. I think the Guardians complete the sweep here so give me Cleveland.

Chris Ruffolo's Pick: Cleveland Guardians -105

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