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Cleveland Guardians vs New York Yankees Prediction 6/4/25 MLB Picks

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New York Yankees (37-22) vs Cleveland Guardians (32-27)

Game Info: Wednesday, June 4, 2025 at 7:05 pm (Yankee Stadium)

The Line: Betting Odds: New York Yankees -185 / Cleveland Guardians +154 — Over/Under: 9

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The Cleveland Guardians and New York Yankees meet Wednesday in MLB action at Yankee Stadium. Here’s a Cleveland Guardians vs New York Yankees Prediction. This article will include a Cleveland Guardians vs New York Yankees Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 32-27 on the year and play the Astros, Reds, and Mariners next. The Cleveland Guardians are batting .234 on the season, have a .307 OBP, and a .378 slugging percentage. The Cleveland Guardians’ pitching staff has a 4.05 ERA and a 1.38 WHIP. Jose Ramirez leads the Cleveland Guardians with 71 hits and 29 RBI, while Steven Kwan and Carlos Santana have combined for 120 hits and 50 RBI. 

Luis Ortiz gets the ball for the Cleveland Guardians, and he is 2-6 with a 4.40 ERA and 64 strikeouts this season. Ortiz is 0-2 with a 5.79 ERA and 15 strikeouts in his career against the New York Yankees.

New York Yankees Betting Preview

The New York Yankees are 37-22 on the year and play the Red Sox, Royals, and Red Sox next. The New York Yankees are batting .258 on the season, have a .343 OBP, and a .467 slugging percentage. The New York Yankees’ pitching staff has a 3.58 ERA and a 1.18 WHIP. Aaron Judge leads the New York Yankees with 86 hits and 50 RBI, while Paul Goldschmidt and Anthony Volpe have combined for 123 hits and 62 RBI.

Clarke Schmidt gets the ball for the New York Yankees, and he is 2-2 with a 3.95 ERA and 42 strikeouts this season. Schmidt is 1-1 with a 5.12 ERA and 25 strikeouts in his career against the Cleveland Guardians.

Why the New York Yankees will win

Why the Cleveland Guardians will win

New York Yankees Player Prop Facts

Cleveland Guardians Player Prop Facts

Cleveland Guardians vs New York Yankees Prediction

The Guardians continue to be hit or miss, and while Ortiz has been OK at times this season, he has a 6.39 ERA and .280 allowed batting average in 31 road innings. Ortiz isn’t going to like the Little League park that is Yankee Stadium. The Yankees continue to pile up the wins, and Schmidt has been more consistent this season, which includes allowing 23 hits and 10 runs in his last 28.2 innings. In 22.2 home innings, Schmidt has a 3.18 ERA and a .195 allowed batting average. The Yankees are at home, the better team, and have the pitching edge. Give me the Yankees, and I’ll lay the RL to shave down the juice.

Randy Chambers's Pick: New York Yankees -1.5

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