Cleveland Guardians vs Minnesota Twins Prediction 9/21/2025 Today’s MLB Picks

The Cleveland Guardians and Minnesota Twins meet Sunday in MLB action at Target Field. Here’s a Cleveland Guardians vs Minnesota Twins Prediction. This article will include a Cleveland Guardians vs Minnesota Twins Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 84-71 on the year and play the Tigers and Rangers next. The Cleveland Guardians are batting .227 on the season, have a .297 OBP, and a .374 slugging percentage. The Cleveland Guardians pitching staff has a 3.69 ERA and a 1.27 WHIP. Steven Kwan leads the Cleveland Guardians with 165 hits and 54 RBI, while Jose Ramirez and Kyle Manzardo have combined for 265 hits and 149 RBI.

Joey Cantillo gets the ball for the Cleveland Guardians, and he is 5-3 with a 3.27 ERA and 95 strikeouts this season. Cantillo is 0-2 with a 3.86 ERA and 22 strikeouts in his career against the Minnesota Twins.

Minnesota Twins Betting Preview

The Minnesota Twins are 66-89 on the year and play the Rangers and Phillies next. The Minnesota Twins are batting .239 on the season, have a .312 OBP, and a .397 slugging percentage. The Minnesota Twins pitching staff has a 4.69 ERA and a 1.34 WHIP. Byron Buxton leads the Minnesota Twins with 123 hits and 76 RBI while Trevor Larnach and Brooks Lee have combined for 232 hits and 122 RBI.

Simeon Woods Richardson gets the ball for the Minnesota Twins, and he is 7-4 with a 4.31 ERA and 95 strikeouts this season. Woods Richardson is 0-1 with a 2.49 ERA and 19 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians @ Minnesota Twins Betting Trends: September 21, 2025

• Probable Starting Pitcher: Simeon Woods-Richardson      Record this season: 7-4      ERA: 4.31
• Home Record: 5-2
• Last 5 against Guardians: 0-1

Why the Minnesota Twins will win

• The underdogs have won nine of the last 13 games between the Guardians and Twins at Target Field.
• The Guardians have failed to cover the run line in each of their last eight Sunday day games against AL Central opponents.
• The Twins have covered the run line in each of their last seven Sunday day games as underdogs against American League opponents.
• The Guardians have trailed after 5 innings in eight of their last nine Sunday day road games.

• Probable Starting Pitcher: Joey Cantillo      Record this season: 5-3      ERA: 3.27
• Road Record: 3-1
• Last 5 against Twins: 0-2

Why the Cleveland Guardians will win

• The Guardians have won each of their last 10 games against AL Central opponents.
• The Twins have lost each of their last nine home games against the Guardians following a home loss.
• The Twins have failed to cover the run line in each of their last 11 games against the Guardians at Target Field following a home loss.
• The Guardians have covered the run line in each of their last nine road games against American League opponents.
• The Guardians have led after 5 innings in each of their last four games at Target Field against AL Central opponents that held a losing record.

Total Runs Facts

• Each of the Guardians’ last four day games against American League opponents have gone UNDER the total runs line.
• Each of the Twins’ last three day games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Twins’ last five games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Guardians’ last five games as road favorites against AL Central opponents.

Minnesota Twins Player Prop Facts

• Byron Buxton has hit a home run in three of the Twins’ last four day games against opponents that held a winning record.
• Ryan Jeffers has recorded at least one hit in each of his last six appearances in day games against AL teams that held a winning record.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in three of the Guardians’ last five games against the Twins.
• Will Brennan has recorded at least one hit in each of his last nine appearances against the Twins.

Matchup/League Facts

• The Twins rank 27th in the league for opponent batting average this season (.260).
• The Twins rank 25th in the league for RBIs this season (620).
• The Guardians rank 29th in the league for on-base percentage this season (.297).
• The Guardians rank 28th in the league for RBIs this season (593).

Cleveland Guardians vs Minnesota Twins Prediction

There’s no reason to go against the Guardians, a team that’s lost one game since September 5, and that includes sweeping a doubleheader yesterday. The Twins look like a team that’s ready for the season to end, and they were shutout twice yesterday. Two teams heading in opposite directions, and the Guardians seem on a mission to make the postseason. I’ll ride the hot hand and roll with the Guardians yet again.