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Cleveland Guardians vs Minnesota Twins Prediction 9/12/2026 Today’s MLB Picks

Jun 28, 2026; Minneapolis, Minnesota, USA;  Minnesota Twins pitcher Connor Prielipp (61) throws a pitch against the Colorado Rockies during the fourth inning at Target Field. Mandatory Credit: Jeffrey Becker-Imagn Images

Jun 28, 2026; Minneapolis, Minnesota, USA; Minnesota Twins pitcher Connor Prielipp (61) throws a pitch against the Colorado Rockies during the fourth inning at Target Field. Mandatory Credit: Jeffrey Becker-Imagn Images

MATCHUP Cleveland Guardians Minnesota Twins
Team Records 75-73 69-78
Spread -1.5 150 +1.5 -182
Moneyline -108 -112
Total Over 9 (-102) Under 9 (-118)
Where Target Field, Minneapolis, Minnesota
When Saturday, September 12, 2026
Time 04:10 PM EDT
TV MLB.TV
In this article, we will formulate a Guardians vs Twins Prediction for this MLB matchup on Saturday, September 12th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview


The Minnesota Twins have a 69-78 record this season and are sitting in the 3rd place of the AL Central. They have a 38-35 home record and are coming off a 2-5 home loss against the Guardians. They will face the Yankees and the Angels next.

The Minnesota Twins have a .245 batting average this season, .319 OBP and .405 Slugging percentage. Minnesota’s pitching staff has a 4.67 ERA and 1.38 WHIP. Luke Keaschall is the team’s best hitter with a .272 batting average. Josh Bell leads the team in RBI with 86, while Kody Clemens adds a team-high 26 home runs.

Connor Prielipp (L) is the projected starting pitcher for the Twins, and he has a 4-7 record, 5.25 ERA and 1.36 WHIP.

Cleveland Guardians Preview


The Cleveland Guardians have a 75-73 record this season and are sitting in the 2nd place of the AL Central. They have a 39-34 away record and are coming off a 5-2 road win against the Twins. They will face the White Sox and the Athletics next.

The Cleveland Guardians have a .237 batting average this season, .314 OBP and .373 Slugging percentage. Cleveland’s pitching staff has a 3.79 ERA and 1.26 WHIP. Chase DeLauter is the team’s best hitter with a .293 batting average. Brayan Rocchio leads the team in RBI with 64, while Angel Martinez adds a team-high 15 home runs.

Daniel Espino (R) is the projected starting pitcher for the Guardians, and he has a 0-0 record, 2.70 ERA and 1.30 WHIP.

Cleveland Guardians @ Minnesota Twins Betting Trends: September 12, 2026


Why the Minnesota Twins will win

Why the Cleveland Guardians will win

Total Runs Facts

Minnesota Twins Player Prop Facts

Cleveland Guardians Player Prop Facts

Matchup/League Facts

Guardians vs Twins Prediction


The Guardians are 4-2 in their last 6 meetings against the Twins and have won their last two visits in Minnesota.

In this Guardians vs Twins Prediction, both teams are coming at a pickem price. I like the Guardians in this one, even though they are going for a bullpen game. Connor Prielipp has been fade material, as he has given up 17 runs across his last three starts and has lost all of his last four starts. The Guardians have superior numbers in their last five games, scoring 5.2 runs to the Twins’ 2.4 and also have a 1.14 bullpen ERA to the Twins’ 7.97. Take the Guardians to win.

Nikos Lagouretos's Pick: Cleveland Guardians ML

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