Cleveland Guardians vs Detroit Tigers Prediction 9/17/2025 Today’s MLB Picks

The Cleveland Guardians and Detroit Tigers meet Wednesday in MLB action at Comerica Park. Here’s a Cleveland Guardians vs Detroit Tigers Prediction. This article will include a Cleveland Guardians vs Detroit Tigers Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 79-71 on the year and play the Twins, Tigers, and Rangers next. The Cleveland Guardians are batting .226 on the season, have a .296 OBP, and a .372 slugging percentage. The Cleveland Guardians pitching staff has a 3.79 ERA and a 1.29 WHIP. Steven Kwan leads the Cleveland Guardians with 158 hits and 49 RBI, while Jose Ramirez and Kyle Manzardo have combined for 258 hits and 145 RBI.

Logan Allen gets the ball for the Cleveland Guardians, and he is 7-11 with a 4.36 ERA and 111 strikeouts this season. Allen is 0-3 with a 7.00 ERA and 14 strikeouts in his career against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 85-66 on the year and play the Braves, Guardians, and Red Sox next. The Detroit Tigers are batting .249 on the season, have a .318 OBP, and a .420 slugging percentage. The Detroit Tigers pitching staff has a 3.92 ERA and a 1.24 WHIP. Riley Greene leads the Detroit Tigers with 149 hits and 108 RBI while Spencer Torkelson and Gleyber Torres have combined for 252 hits and 147 RBI.

Jack Flaherty gets the ball for the Detroit Tigers, and he is 8-13 with a 4.69 ERA and 178 strikeouts this season. Flaherty is 2-3 with a 2.25 ERA and 44 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians @ Detroit Tigers Betting Trends: September 17, 2025

• Probable Starting Pitcher: Jack Flaherty      Record this season: 8-13      ERA: 4.69
• Home Record: 5-7
• Last 5 against Guardians: 2-2

Why the Detroit Tigers will win

• The Tigers have won each of their last eight games at Comerica Park after going to extra innings.
• The Tigers have covered the run line in each of their last four home games after going to extra innings.
• The Guardians have failed to cover the run line in seven of their last eight Wednesday games at Comerica Park.

• Probable Starting Pitcher: Gavin Williams      Record this season: 10-5      ERA: 3.16
• Road Record: 4-3
• Last 5 against Tigers: 1-2

Why the Cleveland Guardians will win

• The Guardians have won each of their last four games as road underdogs against American League opponents.
• The Tigers have lost four of their last five games as favorites.
• The Guardians have covered the run line in each of their last 14 Wednesday games as underdogs.
• The Tigers have failed to cover the run line in eight of their last 10 games as favorites against American League opponents.

Total Runs Facts

• Each of the Guardians’ last six road games following an extra innings win have gone UNDER the total runs line.
• Each of the Tigers’ last five games against American League opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last four games as road underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last three games between the Guardians and Tigers.

Detroit Tigers Player Prop Facts

• Spencer Torkelson has hit a home run in each of the Tigers’ last three games at Comerica Park against AL Central opponents that held a winning record.
• Jack Flaherty has recorded seven or more strikeouts in nine of his last 10 appearances at Comerica Park against opponents that held a winning record.
• Gleyber Torres has recorded at least one hit in each of the Tigers’ last nine night games against AL opponents that held a winning record.
• Jake Rogers has recorded a Double in three of his last four appearances with the Tigers as favorites against AL Central opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 10 games as road underdogs against AL Central opponents.
• Jose Ramirez has recorded a Double in four of the Guardians’ last five games as underdogs against AL opponents.
• Austin Hedges has hit a home run in two of his last three road appearances against AL opponents that held a winning record.

Cleveland Guardians vs Detroit Tigers Prediction

The Guardians have lost once over the last 12 days, and wins like yesterday only add to the confidence. Flaherty will pitch for the first time in a week, and he’s allowed 13 runs in his last 20 innings. The Tigers have lost 8 of the last 11 games Flaherty has pitched. Not thrilled with either pitcher, but the Guardians have caught fire lately, and I’ll bank on that continuing. Give me the Guardians on the road.