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Cleveland Guardians vs Chicago White Sox Prediction 10/7/2026 Today’s MLB Picks

Oct 5, 2026; Cleveland, Ohio, USA;  Cleveland Guardians third baseman Jose Ramirez (11) reacts after striking out against the Chicago White Sox during the eighth inning in game two of the ALDS for the 2026 MLB Playoffs at Progressive Field.  Mandatory Credit: Ken Blaze-Imagn Images

Oct 5, 2026; Cleveland, Ohio, USA; Cleveland Guardians third baseman Jose Ramirez (11) reacts after striking out against the Chicago White Sox during the eighth inning in game two of the ALDS for the 2026 MLB Playoffs at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images

MATCHUP Cleveland Guardians Chicago White Sox
Team Records 85-77 84-78
Spread -1.5 169 +1.5 -207
Moneyline +101 -122
Total Over 8 (-102) Under 8 (-118)
Where Rate Field, Chicago, Illinois
When Wednesday, October 7, 2026
Time 04:00 PM EDT
TV TBS
The Cleveland Guardians and Chicago White Sox meet Wednesday in MLB playoff action at Rate Field. Here’s a Cleveland Guardians vs. Chicago White Sox Prediction. This article will include a Cleveland Guardians vs. Chicago White Sox Pick.

Cleveland Guardians Betting Preview


The Cleveland Guardians need a win to force a game 4 on Thursday. The Guardians haven’t won a game since September 26. The Cleveland Guardians are batting .115 in these playoffs, have a .217 OBP, and a .180 slugging percentage. The Cleveland Guardians pitching staff has a 3.50 ERA and a 1.11 WHIP. Chase DeLauter leads the Cleveland Guardians with 2 hits and 0 RBI, while Patrick Bailey and Steven Kwan have combined for 2 hits and 0 RBI.

Daniel Espino gets the ball for the Cleveland Guardians, and he is 0-0 with a 4.11 ERA and 25 strikeouts this season. Espino is 0-0 with a 4.50 ERA and 3 strikeouts in his career against the Chicago White Sox. Espino is 0-0 with a 0.00 ERA and 0 strikeouts in his postseason career.

Chicago White Sox Betting Preview


The Chicago White Sox look to make the ALCS for the first time since 2005. The White Sox haven’t lost a game since September 26. The Chicago White Sox are batting .235 on the season, have a .325 OBP, and have a .326 slugging percentage. The Chicago White Sox pitching staff has a 1.75 ERA and a 0.81 WHIP. Chase Meidroth leads the Chicago White Sox with 6 hits and 5 RBI, while Kyle Teel and Munetaka Murakami have combined for 8 hits and 5 RBI.

Sean Newcomb gets the ball for the Chicago White Sox, and he is 2-5 with a 3.09 ERA and 84 strikeouts this season. Newcomb is 0-1 with a 2.38 ERA and 13 strikeouts in his career against the Cleveland Guardians. Newcomb is 1-0 with a 2.38 ERA and 9 strikeouts in his postseason career.

Why the Chicago White Sox will win

Why the Cleveland Guardians will win

Total Runs Facts

Chicago White Sox Player Prop Facts

Cleveland Guardians Player Prop Facts

Matchup/League Facts

Cleveland Guardians vs Chicago White Sox Prediction


Both teams are rolling with an opener, so this has a chance to get wild with all of the pitching changes. However, those who have followed along all year know I’ve been backing the White Sox nonstop while oddsmakers kept giving them disrespectful lines. The White Sox were the third most profitable team in the regular season, and they’re comfortably the most profitable team in the playoffs due to four underdog wins. I don’t know why anybody would fade this team, especially with the low prices.

Even on the brink of an ALCS bid, the White Sox are still at best getting pick-em prices. It’s disrespectful, folks. We’ve had a large enough sample size. It’s time to admit the White Sox are good and not just a Disney story. Give me the White Sox.

Randy Chambers's Pick: Chicago White Sox

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