Baltimore (44-55) vs Cleveland (49-50)
July 22, 2025 at 06:40 PM EDT
The Line: Betting Odds: Cleveland -125 — Over/Under: +8.5
The Baltimore Orioles and the Cleveland Guardians meet Tuesday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Cleveland Guardians prediction.
Starting Pitching Matchup
The Baltimore Orioles will send out Brandon Young for the start here and Young is 0-4 with a 7.52 ERA and 25 strikeouts this season. This will be Young’s first career start against the Guardians. Joey Cantillo will get the nod for the Guardians here and Cantillo is 1-0 with a 4.17 ERA and 54 strikeouts this season.
Baltimore Orioles Recap
The Baltimore Orioles come into this game looking to rebound from a 10-5 loss at the hands of the Guardians in Monday’s opener to sit at 44-55 on the year. After this series, the Orioles will head home for a series against the Colorado Rockies.
Orioles Drop 5 Of Their Last 6 Games
Cedric Mullins has 62 hits so far this season as well as 14 doubles, 13 home runs and 42 RBIs with 14 stolen bases and a .216 batting average while Adley Rutschman has 55 hits with 9 doubles, 8 homers and 20 RBIs. Jackson Holliday has 95 hits with 14 doubles, 2 triples, 13 homers and 39 RBIs. Ryan Mountcastle has 46 hits with 13 doubles, 2 homers and 15 RBIs and Gunnar Henderson has a team-high 95 strikeouts as well this season. Ryan O’Hearn’s also chipped in 80 hits with 14 doubles and 12 home runs with 36 RBIs and Heston Kjerstad’s added 4 homers and 19 RBIs.
Why the Baltimore Orioles will win
The Guardians have lost three of their last four games as home favorites following a home win.
The Orioles have won three of their last four games against AL Central opponents that held a losing record.
The Guardians have failed to cover the run line in each of their last nine Tuesday home games against American League opponents.
The Orioles have covered the run line in five of their last six night games following a road loss.
Baltimore Orioles Player Prop Facts
Ramon Laureano has hit a home run in each of the Orioles’ last two games against opponents that held a losing record.
Jorge Mateo has recorded a Double in four of his last five appearances against the Guardians.
Ryan Mountcastle has recorded at least one hit in each of his last 10 appearances against AL opponents that held a losing record.
Cleveland Guardians Recap
The Cleveland Guardians will be looking to add on to their win over the Orioles from Monday’s opener to sit at 49-50 on the year. After this series, the Guardians will square off against the Kansas City Royals on the road.
Guardians Win 8 Of Their Last 10 Games
Steven Kwan has 105 hits as part of a .288 batting average and 6 home runs, 20 doubles, and 32 RBIs. Kyle Manzardo has 60 hits with 12 doubles, 2 triples, 16 home runs, and 38 RBIs as well this year. Gabriel Arias has 17 doubles but also 88 strikeouts, and Manzardo has 76 strikeouts so far this season. Arias has also added 6 home runs and 31 RBIs, and Jose Ramirez has chipped in 20 home runs and 55 RBIs with 29 stolen bases as well. Carlos Santana has also added 75 hits with 11 home runs and 43 RBIs this season.
Why the Cleveland Guardians will win
The Orioles have lost each of their last eight road games against AL Central opponents.
The Guardians have won each of their last 13 Tuesday night games against teams that held a losing record.
The Orioles have failed to cover the run line in each of their last six games as underdogs against AL Central opponents.
The Guardians have covered the run line in five of their last six home games against teams that held a losing record.
Cleveland Guardians Player Prop Facts
Jose Ramirez has hit a home run in six of the Guardians’ last seven night games.
Carlos Santana has recorded at least one hit in each of his last eight appearances against the Orioles.
Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
Jose Ramirez ranks 3rd in the league in Steals (29) this season.
Total Runs Facts
Seven of the last eight games between the Orioles and Guardians have gone OVER the total runs line.
Four of the Orioles’ last five games as underdogs against the Guardians have gone OVER the total runs line.
Baltimore Orioles vs. Cleveland Guardians Prediction
I’m on the Guardians here. I don’t love Cleveland necessarily, but the Guardians have started to string some strong performances together and I think that another one could be in store here. Brandon Young has had some questionable showings and I think that the Guardians could get to him here and the Guardians have the stronger bullpen when you compare the two side-by-side. Give me the Guardians in this one.