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Cleveland Guardians vs Arizona Diamondbacks Prediction 8/20/2025 Today’s MLB Picks

Aug 19, 2025; Phoenix, Arizona, USA; Arizona Diamondbacks infielder Geraldo Perdomo hits an RBI single in the fifth inning against the Cleveland Guardians at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

Aug 19, 2025; Phoenix, Arizona, USA; Arizona Diamondbacks infielder Geraldo Perdomo hits an RBI single in the fifth inning against the Cleveland Guardians at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

MATCHUP Cleveland Guardians Arizona Diamondbacks
Team Records 64-62 62-66
Where Chase Field, Phoenix, Arizona
When Wednesday, August 20, 2025
Time 03:40 PM EDT
TV CLEGuardians.TV

In this article, we will formulate a Guardians vs Diamondbacks Prediction for this MLB game on Wednesday, August 20th at the Chase Field in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 61-66 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 31-31 home record and are 60-59 in over/under They are coming off a 6-5 home victory over the Guardians, which ended their previous four-game losing streak. Under is 4-2 in their last 6 games and are playing the Brewers and the Reds next.

The Diamondbacks have a .250 batting average this season, .326 OBP and .439 slugging percentage. Arizona’s pitching staff has a 4.57 ERA and 1.34 WHIP. Geraldo Perdomo leads the Diamondbacks with 134 hits, adding a team-high 81 RBI. Ketel Marte is the team’s best hitter with a .293 batting average. Corbin Carroll leads the team in home runs with 27.

Brandon Pfaadt (R) is the projected starting pitcher for the Diamondbacks, and he has a 12-8 record, 5.08 ERA and 1.36 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 64-61 record this season and are sitting on the third place of the AL Central. The Guardians have a 33-30 road record and are 59-62 in over/under. They are coming off a 5-6 road defeat by the Dbacks, and are 4-1 in their last 5 games. Over is 4-2-1 in their last 7 games and are playing the Rays and the Rangers next.

The Guardians have a .227 batting average this season, .299 OBP and .375 Slugging percentage. Cleveland’s pitching staff has a 3.86 ERA and 1.31 WHIP. Jose Ramirez leads the Guardians with 134 hits, and he is the team’s best hitter with a .291 batting average. He also leads the team both in RBI, with 66, and in home runs with 26.

Parker Messick (R) is the projected starting pitcher for the Guardians, and this will be his MLB debut.

Why the Arizona Diamondbacks will win

Why the Cleveland Guardians will win

Total Runs Facts

Matchup/League Facts

Guardians vs Diamondbacks Prediction

The Diamondbacks are 6-2 in their last 8 meetings against the Guardians, and are 4-2 in their last 6 meetings in Arizona. Over is 8-3 in their last 11 meetings.

In this Guardians vs Diamondbacks Prediction, the Diamondbacks are coming as -130 home favorites. Pfaadt has been terrible this season for the Dbacks, but he has been significantly better at home, with a 3.76 ERA. I certainly don’t trust Messick in his major league debut, especially when is up against the 6th-best offense in the league, which is even better at home, averaging 5.2 runs per game in Arizona. I expect the Dbacks to keep the momentum from yesterday’s win and extend their winning streak into two games with a home victory today.

Nikos Lagouretos's Pick: Arizona Diamondbacks -120

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