Cleveland Guardians vs Arizona Diamondbacks Prediction 8/20/2025 Today’s MLB Picks

In this article, we will formulate a Guardians vs Diamondbacks Prediction for this MLB game on Wednesday, August 20th at the Chase Field in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 61-66 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 31-31 home record and are 60-59 in over/under They are coming off a 6-5 home victory over the Guardians, which ended their previous four-game losing streak. Under is 4-2 in their last 6 games and are playing the Brewers and the Reds next.

The Diamondbacks have a .250 batting average this season, .326 OBP and .439 slugging percentage. Arizona’s pitching staff has a 4.57 ERA and 1.34 WHIP. Geraldo Perdomo leads the Diamondbacks with 134 hits, adding a team-high 81 RBI. Ketel Marte is the team’s best hitter with a .293 batting average. Corbin Carroll leads the team in home runs with 27.

Brandon Pfaadt (R) is the projected starting pitcher for the Diamondbacks, and he has a 12-8 record, 5.08 ERA and 1.36 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 64-61 record this season and are sitting on the third place of the AL Central. The Guardians have a 33-30 road record and are 59-62 in over/under. They are coming off a 5-6 road defeat by the Dbacks, and are 4-1 in their last 5 games. Over is 4-2-1 in their last 7 games and are playing the Rays and the Rangers next.

The Guardians have a .227 batting average this season, .299 OBP and .375 Slugging percentage. Cleveland’s pitching staff has a 3.86 ERA and 1.31 WHIP. Jose Ramirez leads the Guardians with 134 hits, and he is the team’s best hitter with a .291 batting average. He also leads the team both in RBI, with 66, and in home runs with 26.

Parker Messick (R) is the projected starting pitcher for the Guardians, and this will be his MLB debut.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last five day games following a win.
• The Guardians have lost each of their last five day games against National League opponents following a road loss.
• The Guardians have failed to cover the run line each of their last seven day games against teams that held a losing record.
• The Diamondbacks have covered the run line in each of their last five day games following a win.
• The Diamondbacks have led after 5 innings in seven of their last eight home day games.
• The Diamondbacks have won the first inning in each of their last four day games at Chase Field.
• The Diamondbacks have led after 3 innings in each of their last four home day games.

Why the Cleveland Guardians will win

• The Guardians have won five of their last six games as underdogs following a loss.
• The Diamondbacks have lost four of their last five games as favorites.
• The Guardians have covered the run line in each of their last nine road games against National League opponents after playing the previous day.
• The Diamondbacks have failed to cover the run line in each of their last six home games against American League opponents.
• The Guardians have won the first inning in three of their last four day games against NL West opponents that held a losing record.
• The Guardians have led after 3 innings in each of their last seven Wednesday games as underdogs.
• The Guardians have led after 5 innings in five of their last six day games against National League opponents.

Total Runs Facts

• Six of the Guardians’ last seven road games against NL West opponents have gone UNDER the total runs line.
• Five of the Diamondbacks’ last six day games as favorites have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Guardians’ last nine road games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Diamondbacks’ last four games as favorites against AL Central opponents.

Matchup/League Facts

• The Diamondbacks rank 2nd in the league for triples this season (31).
• The Diamondbacks rank 3rd in the league for RBIs this season (610).
• The Guardians rank 30th in the league for hits this season (932).
• The Guardians rank 30th in the league for batting average this season (.227).

Guardians vs Diamondbacks Prediction

The Diamondbacks are 6-2 in their last 8 meetings against the Guardians, and are 4-2 in their last 6 meetings in Arizona. Over is 8-3 in their last 11 meetings.

In this Guardians vs Diamondbacks Prediction, the Diamondbacks are coming as -130 home favorites. Pfaadt has been terrible this season for the Dbacks, but he has been significantly better at home, with a 3.76 ERA. I certainly don’t trust Messick in his major league debut, especially when is up against the 6th-best offense in the league, which is even better at home, averaging 5.2 runs per game in Arizona. I expect the Dbacks to keep the momentum from yesterday’s win and extend their winning streak into two games with a home victory today.