Cleveland Guardians vs Arizona Diamondbacks Prediction 8/18/2025 Today’s MLB Picks

In this article, we will formulate a Guardians vs Diamondbacks Prediction for this MLB game on Monday, August 18th at the Chase Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 60-65 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 30-30 home record and are 59-58 in over/under They are coming off a 5-6 road defeat by the Rockies, and have three consecutive losses. Under is 3-1 in their last 4 games and are playing the Brewers and the Reds next.

The Diamondbacks have a .251 batting average this season, .326 OBP and .440 slugging percentage. Arizona’s pitching staff has a 4.58 ERA and 1.34 WHIP. Geraldo Perdomo leads the Diamondbacks with 130 hits, adding a team-high 79 RBI. Ketel Marte is the team’s best hitter with a .297 batting average. Corbin Carroll leads the team in home runs with 27.

Zac Gallen (R) is the projected starting pitcher for the Diamondbacks, and he has a 9-12 record, 5.31 ERA and 1.35 WHIP.

Cleveland Guardians Preview

The Cleveland Guardians have a 63-60 record this season and are sitting on the second place of the AL Central. The Guardians have a 32-29 road record and are 58-61 in over/under. They are coming off a 4-5 home defeat by the Braves, and are 1-4 in their last 5 games. Over is 3-1-1 in their last 5 games and are playing the Rays and the Rangers next.

The Guardians have a .228 batting average this season, .300 OBP and .375 Slugging percentage. Cleveland’s pitching staff has a 3.89 ERA and 1.31 WHIP. Jose Ramirez leads the Guardians with 132 hits, and he is the team’s best hitter with a .291 batting average. He also leads the team both in RBI, with 64, and in home runs with 25.

Gavin Williams (R) is the projected starting pitcher for the Guardians, and he has a 7-4 record, 3.38 ERA and 1.31 WHIP.

Why the Arizona Diamondbacks will win

• The Guardians have lost each of their last seven Monday games against NL West opponents.
• The Diamondbacks have won five of their last six games against the Guardians.
• The Diamondbacks have covered the run line in each of their last five games against the Guardians following a loss.
• The Guardians have failed to cover the run line in six of their last seven games against teams that held a losing record.
• The Diamondbacks have led after 5 innings in each of their last eight home games.
• The Diamondbacks have led after 3 innings in three of their last four home games.
• The Diamondbacks have won the first inning in each of their last seven games against opponents that held a winning record at Chase Field.

Why the Cleveland Guardians will win

• The Guardians have won seven of their last eight games as underdogs after playing the previous day.
• The Diamondbacks have lost five of their last six games as favorites against American League opponents.
• The Guardians have covered the run line in each of their last seven road games against National League opponents after playing the previous day.
• The Diamondbacks have failed to cover the run line in each of their last four home games against American League opponents.
• The Diamondbacks have trailed after 5 innings in each of their last four games against AL Central opponents.
• The Guardians have led after 3 innings in four of their last five games against NL West opponents.
• The Guardians have won the first inning in each of their last four road games against NL West opponents that held a losing record.

Total Runs Facts

• Each of the Guardians’ last five road games against NL West opponents have gone UNDER the total runs line.
• Four of the Diamondbacks’ last five games as favorites against the Guardians have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last seven home games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Guardians’ last seven road games against National League opponents.

Matchup/League Facts

• The Diamondbacks rank 2nd in the league for triples this season (27).
• The Diamondbacks rank 2nd in the league for slugging percentage this season (.440).
• The Guardians rank 30th in the league for hits this season (919).
• The Guardians rank 30th in the league for batting average this season (.228).

Guardians vs Diamondbacks Prediction

The Diamondbacks are 5-1 in their last 6 meetings against the Guardians, and are 3-1 in their last 4 meetings in Arizona. Over is 7-2 in their last 9 meetings.

In this Guardians vs Diamondbacks Prediction, the Diamondbacks are coming as -125 home favorites. Both teams have been struggling lately, and in no way shape or form I am going to back Gallen this season. He has been struggling throughout the whole season and has been weaker at home, with a 5.59 home ERA. Gavin Williams for the Guardians has been better overall this season and has been in better form lately, having given up one run or less in three of his last five starts. The Dbacks have the fourth-worst bullpen in the league, so I like the Guardians as underdogs in this matchup. I expect them to lock this game from start to finish and get away with the road victory.