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Cincinnati Reds vs Seattle Mariners Prediction 7/22/2026 Today’s MLB Picks

Oct 13, 2025; Toronto, Ontario, CAN; Seattle Mariners pitcher Emerson Hancock (26) pitches against the Toronto Blue Jays in the eighth inning during game two of the ALCS round for the 2025 MLB playoffs at Rogers Centre. Mandatory Credit: Dan Hamilton-Imagn Images

Oct 13, 2025; Toronto, Ontario, CAN; Seattle Mariners pitcher Emerson Hancock (26) pitches against the Toronto Blue Jays in the eighth inning during game two of the ALCS round for the 2025 MLB playoffs at Rogers Centre. Mandatory Credit: Dan Hamilton-Imagn Images

MATCHUP Cincinnati Reds Seattle Mariners
Team Records 46-54 51-51
Spread +1.5 -174 -1.5 143
Moneyline +123 -148
Total Over 8 (-112) Under 8 (-108)
Where T-Mobile Park, Seattle, Washington
When Wednesday, July 22, 2026
Time 03:40 PM EDT
TV MLB.TV
In this article, we will formulate a Reds vs Mariners Prediction for this MLB matchup on Wednesday, July 22nd in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview


The Seattle Mariners have a 51-51 record this season and are sitting in the 2nd place of the AL West. They have a 30-22 home record and are coming off a 2-4 home loss against the Reds. They will face the Rangers and the Dodgers next.

The Seattle Mariners have a .230 batting average this season, .310 OBP and .378 Slugging percentage. Seattle’s pitching staff has a 3.57 ERA and 1.17 WHIP. Randy Arozarena is the team’s best hitter with a .282 batting average. Cole Young leads the team in RBI with 48, while Luke Raley adds a team-high 15 home runs.

Emerson Hancock (R) is the projected starting pitcher for the Seattle Mariners, and he has a 6-4 record, 3.17 ERA and 1.01 WHIP.

Cincinnati Reds Preview


The Cincinnati Reds have a 46-54 record this season and are sitting in the 5th place of the NL Central. They have a 24-26 away record and are coming off a 4-2 road win against the Mariners. They will face the Cardinals and the Guardians next.

The Cincinnati Reds have a .230 batting average this season, .310 OBP and .399 Slugging percentage. Cincinnati’s pitching staff has a 4.60 ERA and 1.44 WHIP. Elly De La Cruz is the team’s best hitter with a .280 batting average. Sal Stewart leads the team in RBI with 71, adding a team-high 20 home runs.

Brady Singer (R) is the projected starting pitcher for the Cincinnati Reds, and he has a 4-9 record, 4.56 ERA and 1.41 WHIP.

Cincinnati Reds @ Seattle Mariners Betting Trends: July 22, 2026


Why the Seattle Mariners will win


Why the Cincinnati Reds will win

Total Runs Facts

Seattle Mariners Player Prop Facts

Cincinnati Reds Player Prop Facts

Matchup/League Facts

Reds vs Mariners Prediction


The Mariners are 7-2 in their last 9 meetings against the Reds and are 4-1 in their last 5 meetings in Seattle.

In this Reds vs Mariners Prediction, the Mariners are coming as -150 home favorites. I like the Mariners in a bounce-back spot at home today, as they have the pitching edge with Hancock going up against Brady Singer. Hancock has been unhittable lately with a 0.63 ERA across his last three starts and a solid 2.92 home ERA, while Singer has been terrible on the road with a 1-5 record and 6.14 ERA. On top of that, the Mariners have a better bullpen and are much better against right-handed pitching, so I expect them to get the job done at home in this one.

Nikos Lagouretos's Pick: Seattle Mariners ML

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