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Cincinnati Reds vs Pittsburgh Pirates Prediction 5/19/25 MLB Picks

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Pittsburgh Pirates (15-32) vs Cincinnati Reds (24-24)

Game Info: Monday, May 19, 2025 at 6:40 pm (PNC Park)

The Line: Betting Odds: Pittsburgh Pirates +110 / Cincinnati Reds -130 — Over/Under: 8

(Get latest betting odds)

The Cincinnati Reds and Pittsburgh Pirates meet Monday in MLB action at PNC Park. Here’s a Cincinnati Reds vs Pittsburgh Pirates Prediction. This article will include a Cincinnati Reds vs Pittsburgh Pirates Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 24-24 on the year and play the Cubs, Royals, and Cubs next. The Cincinnati Reds are batting .243 on the season, have a .320 OBP, and a .395 slugging percentage. The Cincinnati Reds pitching staff has a 3.58 ERA and a 1.17 WHIP. Elly De La Cruz leads the Cincinnati Reds with 46 hits and 31 RBI, while TJ Friedl and Gavin Lux have combined for 87 hits and 36 RBI. 

Nick Lodolo gets the ball for the Cincinnati Reds, and he is 3-4 with a 3.42 ERA and 42 strikeouts this season. Lodolo is 2-2 with a 4.30 ERA and 37 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 15-32 on the year and play the Brewers, Diamondbacks, and Padres next. The Pittsburgh Pirates are batting .217 on the season, have a .297 OBP, and a .322 slugging percentage. The Pittsburgh Pirates’ pitching staff has a 4.08 ERA and a 1.27 WHIP. Ke’Bryan Hayes leads the Pittsburgh Pirates with 41 hits and 15 RBI, while Bryan Reynolds and Isiah Kiner-Falefa have combined for 71 hits and 30 RBI.

Mitch Keller gets the ball for the Pittsburgh Pirates, and he is 1-5 with a 4.15 ERA and 43 strikeouts this season. Keller is 3-5 with a 6.06 ERA and 78 strikeouts in his career against the Cincinnati Reds.

Why the Pittsburgh Pirates will win

Why the Cincinnati Reds will win

Pittsburgh Pirates Player Prop Facts

Cincinnati Reds Player Prop Facts

Cincinnati Reds vs Pittsburgh Pirates Prediction

The Reds are playing their best ball of the season with four straight wins, and they should like their chances to keep things rolling against a bad Pirates side. The Pirates have won four games since April 26, and their offense has scored three or fewer runs in 11 of their last 14 games. In 31.1 road innings, Lodolo has a 1.44 ERA and .186 allowed batting average. In 27 home innings, Keller has a 5.33 ERA and a .279 allowed batting average. There’s no reason to look in the Pirates’ direction, especially with a line this soft. Give me the Reds.

Randy Chambers's Pick: Cincinnati Reds -130

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