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Cincinnati Reds vs Milwaukee Brewers Prediction 9/28/2025 Today’s MLB Picks

Aug 23, 2025; Phoenix, Arizona, USA; Cincinnati Reds starting pitcher Andrew Abbott (41) on the mound in the first inning against the Arizona Diamondbacks at Chase Field. Mandatory Credit: Allan Henry-Imagn Images

Aug 23, 2025; Phoenix, Arizona, USA; Cincinnati Reds starting pitcher Andrew Abbott (41) on the mound in the first inning against the Arizona Diamondbacks at Chase Field. Mandatory Credit: Allan Henry-Imagn Images

MATCHUP Cincinnati Reds Milwaukee Brewers
Team Records 83-78 96-65
Where American Family Field, Milwaukee, Wisconsin
When Saturday, September 27, 2025
Time 07:15 PM EDT
TV FOX

In this article, we will formulate a Reds vs Brewers Prediction for this MLB game on Saturday, September 27th at the American Family Field in the second game of this series, with the Reds having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 96-64 record this season and are sitting on the 1st place of the NL Central. The Brewers have a 51-28 home record and are 76-79 in over/under. They are coming off a 1-3 home defeat by the Reds, and are 1-4 in their last 5 games. Under is 5-1 in their last 6 games.  

The Brewers have a .259 batting average this season, .332 OBP and .403 slugging percentage. Milwaukee’s pitching staff has a 3.61 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 166 hits, while Sam Frelick is the team’s best hitter, with a .291 batting average. Christian Yelich leads the team in RBI, with 102, adding a team-high 29 home runs.

Robert Gasser (L) is the projected starting pitcher for the Brewers, and he has a 0-1 record, 6.00 ERA and 1.00 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have an 82-78 record this season and are sitting in the third place of the NL Central. The Reds have a 37-42 road record and are 58-92 in over/under. They are coming off a 3-1 road victory over the Brewers, and have back-to-back wins. Under is 7-1-2 in their last 10 games.

The Reds have a .245 batting average this season, .315 OBP and .391 slugging percentage. Cincinnati’s pitching staff has a 3.86 ERA and 1.22 WHIP.  Elly De La Cruz leads the Reds with 164 hits, and in RBI, with 85, while Spencer Steer adds a team-high 21 home runs. Gavin Lux is the team’s best hitter with a .269 batting average.

Andrew Abbott (L) is the projected starting pitcher for the Reds, and he has a 9-7 record, 2.80 ERA and 1.16 WHIP.

Cincinnati Reds @ Milwaukee Brewers Betting Trends: September 27, 2025

Why the Milwaukee Brewers will win

Why the Cincinnati Reds will win

Total Runs Facts

Milwaukee Brewers Player Prop Facts

Cincinnati Reds Player Prop Facts

Matchup/League Facts

Reds vs Brewers Prediction

The Brewers are 7-4 in their last 11 meetings against the Reds, and are 3-2 in their last 5 meetings in Milwaukee.

In this Reds vs Brewers Prediction, the Brewers are coming as -155 home favorites. The Reds are still fighting with the Mets for the third Wild Card spot in the NL, while the Brewers have already clinched their playoff spot. Reds put Abbott on the mound, who has been excellent this season, and in his previous start he shut out the Cubs. I don’t trust Gasser on the mound for the Brewers, who have no incentive to win, so I like the Reds as a road dog in this spot. Take the Cincinnati Reds and the plus money in this one.

Nikos Lagouretos's Pick: Cincinnati Reds ML

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