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Cincinnati Reds vs Chicago Cubs Prediction 6/1/25 MLB Picks

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Chicago Cubs (36-22) vs Cincinnati Reds (29-30)

June 1, 2025 at 02:20 PM EDT

The Line: Betting Odds: Chicago Cubs -162 / Cincinnati Reds +136 — Over/Under: 7.5

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In this article, we will formulate a Cincinnati Reds vs Chicago Cubs prediction for this MLB game on Sunday, June 1st, at Wrigley Field. To formulate this prediction, we will look at: 

-The Reds’ recent form and recent player performance

-The Cubs’ recent form and recent player performance

-Recent Betting trends and streaks involving Cincinnati

-Recent Betting trends and streaks involving Chicago

-Recent betting trends in games played between Chicago and Cincinnati

-A summary that ties it all together produces a favorable betting outcome for Today’s Game between the Reds and Cubs. 

How Do the Reds Get the Offense Going?

The Reds offense was awful on Saturday and they are going to need to find a way to bounce back in a big way here. The Reds managed a grand total of one hit, and that led to the defeat. It was disappointing because Nick Lodolo had a strong game, going six innings, giving up five hits and zero runs. 

Overall, this season the Reds’ offense has been strong and they are averaging 4.58 runs per game. The pitching overall is averaging 4.0 runs per game, which is 12th in the league. Elly De La cruz has hit 11 home runs and driven in 40 RBIs. Getting the start for the Reds will be Nick Martinez who sits with a 3-5 record and an ERA of 3.48. Against the Kansas City Royals in his last start he went seven innings giving up six hits and three runs. Two games ago against the Pittsburgh Pirates he went six innings giving up four hits and one run. 

Why the Reds Will Beat the Cubs

  • The Cubs have lost seven of their last eight games as home favorites against NL Central opponents following a home win.
  • The Reds have won four of their last five games as road underdogs following a loss.
  • The Cubs have failed to cover the run line in each of their last seven home games against National League opponents following a home win.
  • The Reds have covered the run line in eight of their last nine games as road underdogs following a road loss.
  • The Reds have won the first inning in four of their last five day games against opponents that held a winning record.
  • The Cubs have trailed after 3 innings in four of their last five day games against NL Central opponents that held a losing record.
  • The Cubs have trailed after 5 innings in four of their last five games against NL Central opponents.

Another win for the Cubs

The Cubs look to be a true contender and they picked up another big win on Saturday. The pitching was dominant giving up only one hit and that was enough for the 2-0 victory. Ben Brown got the majority of the work and he went six innings giving up one hit and zero runs. Seiya Suzuki was the top offensive player, finishing with a hit and an RBI. 

The Cubs’ offense is ranked at the top in all of baseball, and they are averaging 5.76 runs per game. The pitching is pretty middle of the road and they are giving up 4.15 runs per game which is 14th. Pete Crow Armstrong is having a strong season, and he has hit 15 home runs and driven in 50 RBIs. Getting the start for the Cubs in this game will be Jameson Taillon, who sits with a 4-3 record and an ERA of 3.86. Against the Colorado Rockies in his last start, he went 6.1 innings, giving up four hits and one run. 

Why the Cubs Will Beat the Reds

  • The Cubs have won eight of their last nine home games after playing the previous day.
  • The Reds have lost three of their last four road games against NL Central opponents.
  • The Reds have failed to cover the run line in each of their last three road games against National League opponents after playing the previous day.
  • The favorites have covered the run line in three of the Reds’ last four games at Wrigley Field.

Cincinnati Reds vs Chicago Cubs Prediction

The wind is expected to be blowing in at Wrigley Field, and combine that with two good pitchers on the mound, we have a perfect recipe for a low-scoring game. Taillon has been strong this season and in his last start he gave up only one run total. Martinez hasn’t always had the most run support, but he has been good. Two starts ago, he gave up only one run, and with the wind blowing in, the Cubs’ offense is going to really struggle. It’s going to be a classic pitchers duel and the under will cash. 

Shane Mickle's Pick: Under

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