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Chicago White Sox vs Washington Nationals Prediction 9/28/2025 Today’s MLB Picks

Sep 27, 2025; Washington, District of Columbia, USA; Chicago White Sox shortstop Chase Meidroth (10) reacts after striking out with a runner on third base to end the game against the Washington Nationals at Nationals Park. Mandatory Credit: Geoff Burke-Imagn Images

Sep 27, 2025; Washington, District of Columbia, USA; Chicago White Sox shortstop Chase Meidroth (10) reacts after striking out with a runner on third base to end the game against the Washington Nationals at Nationals Park. Mandatory Credit: Geoff Burke-Imagn Images

MATCHUP Chicago White Sox Washington Nationals
Team Records 60-102 66-96
Where Nationals Park, Washington, District of Columbia
When Sunday, September 28, 2025
Time 03:05 PM EDT
TV MLB.TV

The Chicago White Sox and Washington Nationals meet Sunday in
 action at Nationals Park. Here’s a Chicago White Sox vs Washington Nationals Prediction. This article will include a Chicago White Sox vs Washington Nationals Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 59-102 on the year after playing the Yankees. The Chicago White Sox are batting .232 on the season, have a .301 OBP, and a .372 slugging percentage. The Chicago White Sox pitching staff has a 4.30 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 135 hits and 75 RBI, while Miguel Vargas and Chase Meidroth have combined for 231 hits and 81 RBI.

Shane Smith gets the ball for the Chicago White Sox, and he is 6-8 with a 3.98 ERA and 137 strikeouts this season. This will be Smith’s first career game against the Washington Nationals.

Washington Nationals Betting Preview

The Washington Nationals are 66-95 on the year after playing the Braves. The Washington Nationals are batting .243 on the season, have a .306 OBP, and a .391 slugging percentage. The Washington Nationals pitching staff has a 5.33 ERA and a 1.45 WHIP. James Wood leads the Washington Nationals with 153 hits and 94 RBI, while CJ Abrams and Luis Garcia Jr. have combined for 272 hits and 126 RBI.

Brad Lord gets the ball for the Washington Nationals, and he is 5-9 with a 4.12 ERA and 104 strikeouts this season. This will be Lord’s first career game against the Chicago White Sox.

The Chicago White Sox @ Washington Nationals Betting Trends: September 28, 2025

Why the Washington Nationals will win

Why the Chicago White Sox will win

Total Runs Facts

Washington Nationals Player Prop Facts

Chicago White Sox Player Prop Facts

Chicago White Sox vs Washington Nationals Prediction

I’m not running to the window to get involved in a game with both teams having their bags packed already. The White Sox have also won just two games since September 12. With that said, the White Sox have the edge with Smith on the mound, a rookie who has a 3.98 ERA and 1.24 WHIP. Smith has allowed 25 hits and 13 runs in his last 33.1 innings. Lord has been far more inconsistent, and he has a 5.01 ERA and .280 allowed batting average in 64.2 home innings. Give me the White Sox.

Randy Chambers's Pick: Chicago White Sox

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