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Chicago White Sox vs Seattle Mariners Prediction 5/18/2026 Today’s MLB Picks

May 6, 2026; Seattle, Washington, USA; Seattle Mariners starting pitcher Bryan Woo (22) delivers a pitch in the second inning against the Atlanta Braves at T-Mobile Park. Mandatory Credit: Kevin Ng-Imagn Images

May 6, 2026; Seattle, Washington, USA; Seattle Mariners starting pitcher Bryan Woo (22) delivers a pitch in the second inning against the Atlanta Braves at T-Mobile Park. Mandatory Credit: Kevin Ng-Imagn Images

MATCHUP Chicago White Sox Seattle Mariners
Team Records 24-22 22-26
Spread +1.5 -163 -1.5 135
Moneyline +135 -163
Total Over 7 (-125) Under 7 (104)
Where T-Mobile Park, Seattle, Washington
When Monday, May 18, 2026
Time 09:40 PM EDT
TV ESPN Unlmtd

In this article, we will formulate a White Sox vs Mariners Prediction for this MLB matchup on Monday, May 18th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 22-26 record this season and are sitting in the third place of the AL West. They have a 12-14 home record and are coming off a 8-3 loss against the Padres. They will face the Royals and the Athletics next.

The Mariners have a .228 batting average this season, .319 OBP and .376 Slugging percentage. Seattle’s pitching staff has a 3.75 ERA and 1.23 WHIP. Randy Arozarena is the team’s best hitter with a .301 batting average. Luke Raley leads the team in RBI with 27. Luke Raley adds a team high 10 home runs.

Bryan Woo (R) is the projected starting pitcher for the Mariners, and he has a 3-2 record, 3.91 ERA and 1.00 WHIP.

Chicago White Sox Preview

The Chicago White Sox have a 24-22 record this season and are sitting in the second place of the AL Central. They have a 10-12 away record and are coming off a 9-8 win against the Cubs. They will face the Giants and the Twins next.

The White Sox have a .236 batting average this season, .325 OBP and .412 Slugging percentage. Chicago’s pitching staff has a 4.35 ERA and 1.38 WHIP. Chase Meidroth is the team’s best hitter with a .262 batting average. Munetaka Murakami leads the team in RBI with 32. Munetaka Murakami adds a team high 17 home runs.

Noah Schultz (L) is the projected starting pitcher for the White Sox, and he has a 2-2 record, 4.91 ERA and 1.36 WHIP.

The Chicago White Sox @ Seattle Mariners Betting Trends: May 18, 2026

Why the Seattle Mariners will win

Why the Chicago White Sox will win

Total Runs Facts

Seattle Mariners Player Prop Facts

Chicago White Sox Player Prop Facts

Matchup/League Facts

White Sox vs Mariners Prediction

The Mariners are 7-3 in their last 10 meetings against the White Sox and have won their last three meetings in Seattle.

In this White Sox vs Mariners Prediction, the Mariners are coming as -180 home favorites. The White Sox have been red-hot lately with a 7-1 record in their last 8 games while the Mariners got swept by the Padres at home by 0-3 wins. The Mariners have been terrible against lefties and dead last against southpaws in the last couple of weeks and Woo has been up and down lately, so there is huge value with the road dog in this spot. I will take a stab with the White Sox on the moneyline for good plus money.

Nikos Lagouretos's Pick: Chicago White Sox ML

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