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Chicago White Sox vs San Diego Padres Prediction MLB Picks 9/21/24

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San Diego Padres (87-66) vs Chicago White Sox (36-117)

Game Info: Saturday, September 21, 2024 at 8:40 pm (Petco Park)

The Line: Betting Odds: San Diego Padres -263 / Chicago White Sox +218 — Over/Under: 7.5

(Get latest betting odds)

The Chicago White Sox and the San Diego Padres square off Saturday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. San Diego Padres prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Chris Flexen for the start here and Flexen is 2-14 with a 5.09 ERA and 113 strikeouts this season. In his career, Flexen is 1-2 with an 8.74 ERA and 11 strikeouts against the Padres. Martin Perez will get the start for the Padres here and is 4-5 with a 4.36 ERA and 98 strikeouts this season. In his last five starts against the White Sox, Perez is 1-2 with a 6.15 ERA and 18 strikeouts.

Chicago White Sox Recap

The Chicago White Sox will try to bounce back after ending up on the wrong side of a 3-2 loss to the Padres in Friday’s series opener. The loss put the White Sox in a tough spot in trying to bounce back from a series loss to the Angels last time out.

White Sox Headed For Unfortunate History

Entering Friday, Gavin Sheets has a .238 batting average and a .309 OBP along with 24 doubles and 45 RBIs while Andrew Vaughn has 19 homers and 67 RBIs and Andrew Benintendi has 19 home runs and 60 RBIs with Vaughn logging 29 doubles as well as a team-high 132 hits.

Why the Chicago White Sox will win

San Diego Padres Recap

The San Diego Padres come into this game looking to build on their victory over the White Sox, albeit a narrow one, from Friday’s opener. The win put the Padres on the right path to build on their series wins over the Houston Astros and San Francisco Giants over the last week.

Padres Inching Closer To Playoffs

Going into Friday’s opener, Jurickson Profar has 151 hits along with a .283 batting average and 27 doubles with 23 homers and 83 RBIs. Jake Cronenworth has 78 RBIs while Fernando Tatis Jr. has belted 19 home runs, 46 RBIs, and 103 hits as well this season. Manny Machado has 157 hits, 29 home runs, and 104 RBIs but also has 114 strikeouts while Ha-Seong Kim has 94 hits with 3 triples, 16 doubles, 11 home runs, 47 RBIs, and a team-high 22 stolen bases. Jackson Merrill has also chipped in 24 home runs, 86 RBIs, and 28 doubles with 6 triples this season.

Why the San Diego Padres will win

White Sox vs. Padres Prediction

I’m on the Padres in this one. Hopefully, San Diego can open it up a bit more here as they should’ve been ahead by a lot more than a 3-2 final score that we got on Friday. Chris Flexen’s struggled this year, and the White Sox have only managed to win 3 games with Flexen as a starter. Perez has been a nice acquisition for the Padres and San Diego’s won the majority of Perez’s starts in a Padre uniform. I’ll side with San Diego here.

Chris Ruffolo's Pick: San Diego -263

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