Chicago White Sox vs Minnesota Twins Prediction 9/2/2025 Today’s MLB Picks

In this article, we will formulate a White Sox vs Twins Prediction for this MLB game on Tuesday, September 2nd at the Target Field in the second game of this series, with the White Sox having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 62-75 record this season and are sitting on the 4th place of the AL Central. The Twins have a 35-33 home record and are 64-64 in over/under. They are coming off a 5-6 home defeat by the White Sox, and are 3-6 in their last 9 games. Over is 10-1 in their last 11 games and are playing the Angels and the Royals next.

The Twins have a .238 batting average this season, .311 OBP and .397 Slugging percentage. Minnesota’s pitching staff has a 4.47 ERA and 1.32 WHIP. Byron Buxton leads the Twins with 109 hits, adding team-highs both in RBI, with 72, and in home runs, with 29. He is also the team’s best hitter with a .272 batting average.

Simeon Woods Richardson (R) is the projected starting pitcher for the Twins, and he has a 5-4 record, 4.59 ERA and 1.42 WHIP.

Chicago White Sox Preview

The Chicago White Sox have a 50-88 record this season and are sitting on the last place of the AL Central. The White Sox have a 20-46 road record and are 64-66 in over/under. They are coming off a 6-5 road victory over the Twins, and have back-to-back wins. Over is 5-2 in their last 7 games and are playing the Rays and the Tigers next.

The White Sox have a .234 batting average this season, .302 OBP and .374 Slugging percentage. Chicago’s pitching staff has a 4.23 ERA and 1.37 WHIP. Lenyn Sosa leads the White Sox with 117 hits, and he is the team’s best hitter with a .266 batting average. He also leads the team in RBI with 61, adding a team-high 18 home runs.

Davis Martin (R) is the projected starting pitcher for the White Sox, and he has a 5-9 record, 4.03 ERA and 1.28 WHIP.

Why the Minnesota Twins will win

• The Twins have won each of their last six night games against the White Sox following a loss.
• The White Sox have lost 15 of their last 17 road games against AL Central opponents.
• The Twins have covered the run line in each of their last nine Tuesday games against AL Central opponents.
• The White Sox have failed to cover the run line in each of their last four night games against American League opponents.
• The Twins have led after 3 innings in each of their last seven night games against the White Sox at Target Field.
• The Twins have led after 5 innings in four of their last five games.

Why the Chicago White Sox will win

• The Twins have lost seven of their last eight games as home favorites after playing the previous day.
• The White Sox have won four of their last five games as underdogs against the Twins.
• The White Sox have covered the run line in each of their last seven games following a win.
• The Twins have failed to cover the run line in eight of their last nine games as home favorites against American League opponents.
• The Twins have trailed after 3 innings in each of their last seven games against opponents that held a losing record.
• The White Sox have led after 5 innings in five of their last six games against AL Central opponents.
• The Twins have lost the first inning in three of their last four night games against AL Central opponents.

Total Runs Facts

• Each of the Twins’ last seven games have gone OVER the total runs line.
• Four of the White Sox’s last five night games as underdogs have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last eight home games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last eight Tuesday games against AL Central opponents.

Matchup/League Facts

• The Twins rank 3rd in the league for walks allowed this season (383).
• The Twins rank 26th in the league for opponent batting average this season (.258).
• The White Sox rank 29th in the league for walks allowed this season (512).
• The White Sox rank 28th in the league for batting average this season (.234).

White Sox vs Twins Prediction

The White Sox are 4-1 in their last 5 head-to-head meetings against the Twins, but the Twins are 3-2 in their last 5 meetings in Minnesota. Over is 7-3-1 in their last 11 meetings.

In this White Sox vs Twins Prediction, the Twins are coming as -154 home favorites. I don’t trust either pitcher in this matchup, as Richardson has not been in the best form lately, with a 5.14 ERA across his last 5 starts, while Martin has been weaker on the road, with a 4.58 road ERA. Minnesota’s offense has been red-hot lately, with 5+ runs in five of their last six games, and both bullpens have 4.00+ ERA. Yesterday’s game had 11 total runs, and with both teams with nothing to play for, I expect another high-scoring affair. Take the over 9 runs.