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Chicago White Sox vs Los Angeles Angels Prediction 5/4/2026 Today’s MLB Picks

Apr 28, 2026; Chicago, Illinois, USA; Los Angeles Angels pitcher Jose Soriano (59) throws against the Chicago White Sox during the first inning at Rate Field. Mandatory Credit: Patrick Gorski-Imagn Images

Apr 28, 2026; Chicago, Illinois, USA; Los Angeles Angels pitcher Jose Soriano (59) throws against the Chicago White Sox during the first inning at Rate Field. Mandatory Credit: Patrick Gorski-Imagn Images

MATCHUP Chicago White Sox Los Angeles Angels
Team Records 16-18 13-22
Spread +1.5 -163 -1.5 135
Moneyline +135 -163
Total Over 7.5 (-110) Under 7.5 (-110)
Where Angel Stadium, Anaheim, California
When Monday, May 4, 2026
Time 09:38 PM EDT
TV MLB.TV
In this article, we will formulate a White Sox vs Angels Prediction for this MLB matchup on Monday, May 4th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Preview


The Los Angeles Angels have a 13-22 record this season and are sitting on the fifth place of the AL West. They have a 6-9 home record and are coming off a 1-5 loss at home against the Mets. Their previous three games were a 4-3 win and a 3-4 loss at home against the Mets, and a 2-3 loss on the road against the White Sox.

The Angels have a .233 batting average this season, .326 OBP and .386 Slugging percentage. Los Angeles’ pitching staff has a 4.54 ERA and 1.42 WHIP. Jo Adell is the team’s best hitter with a .268 batting average. Jorge Soler leads the team in RBI with 26, and Mike Trout adds a team‑high 10 home runs.

Jose Soriano (R) is the projected starting pitcher for the Angels, and he has a 5-1 record, 0.84 ERA and 0.94 WHIP.

Chicago White Sox Preview


The Chicago White Sox have a 16-18 record this season and are sitting on the third place of the AL Central. They have a 9-10 road record and are coming off a 3-4 loss on the road against the Padres. Their previous three games were a 4-0 and an 8-2 win on the road against the Padres, and a 3-2 win at home against the Angels.

The White Sox have a .226 batting average this season, .320 OBP and .380 Slugging percentage. Chicago’s pitching staff has a 4.25 ERA and 1.39 WHIP. Chase Meidroth is the team’s best hitter with a .267 batting average. Munetaka Murakami leads the team in RBI with 26, also adding a team‑high 13 home runs.

Davis Martin (R) is the projected starting pitcher for the White Sox, and he has a 4-1 record, 1.95 ERA and 1.08 WHIP.

The Chicago White Sox @ Los Angeles Angels Betting Trends: May 4, 2026


Why the Los Angeles Angels will win


Why the Chicago White Sox will win

Total Runs Facts

Los Angeles Angels Player Prop Facts

Chicago White Sox Player Prop Facts

Matchup/League Facts

White Sox vs Angels Prediction


The White Sox are 5-1 in their last 6 meetings against the Angels and are 2-1 in their last three visits in Los Angeles.

In this White Sox vs Angels Prediction, the Angels are coming as -160 home favorites. Soriano is taking the mound for the Angels and he has been lights out this season, but coming off his worst start, which was against the same White Sox team and he gave up three runs. Martin has also been excellent for Chicago with three earned runs across his last three starts and the White Sox have been in far better form, with a 5-1 record in their last 6 games, while the Angels are 1-8 in their last 9 and were swept by the White Sox last week. Take the White Sox on the moneyline for plus money in this one.

Nikos Lagouretos's Pick: Chicago White Sox ML

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