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Chicago White Sox vs Los Angeles Angels Prediction 08/01/2025 Picks

Jul 21, 2025; New York City, New York, USA; Los Angeles Angels starting pitcher Tyler Anderson (31) pitches against the New York Mets during the first inning at Citi Field. Mandatory Credit: Brad Penner-Imagn Images

Jul 21, 2025; New York City, New York, USA; Los Angeles Angels starting pitcher Tyler Anderson (31) pitches against the New York Mets during the first inning at Citi Field. Mandatory Credit: Brad Penner-Imagn Images

Chicago (40-69) vs Los Angeles (53-56)

August 1, 2025 at 09:38 PM EDT

The Line: Betting Odds: Los Angeles -1.5 — Over/Under: +9.5

(Get latest betting odds)

In this article, we will formulate a White Sox vs Angels prediction for this MLB game on Friday, August 1, at Angel Stadium in Anaheim, California. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Betting Preview

The Chicago White Sox (40-69, 16-37 Away) are playing very well in the second half of the season. They opened this period with a sweep of the Pirates and then beat the Rays; both series were on the road. Following a series of losses to the city rivals Cubs, the White Sox defeated the Phillies. In a rubber match on Wednesday, Chicago secured a 9-3 victory. Miguel Vargas and Edgar Quero led the offense with three RBI apiece, while Tyler Alexander pitched for 3.1 innings in a no-decision, allowing two runs on three hits with three strikeouts and one walk. Mike Vasil was credited with the win.

This season, the White Sox average 3.82 runs per game (27th in the MLB) on a .229/.299/.365 triple-slash. When it comes to pitching, the White Sox’s staff has a 4.09 ERA (18th) and 1.37 WHIP (25th). Miguel Vargas leads the White Sox with a .227 batting average, 13 home runs, and 44 RBI this season.

At the time of writing, the White Sox still haven’t announced the name of the starting pitcher for this clash against the Angels.

Los Angeles Angels Betting Preview

The Los Angeles Angels (53-56, 28-26 Home) bounced back from being swept at the hands of the New York Mets with a series split with the Seattle Mariners and a win over the Texas Rangers. The Angels had a chance to sweep the Rangers, but Texas avoided a sweep with a 6-3 win on Wednesday. Nolan Schanuel led the offense with a two-run homer, while Jose Soriano took the loss after allowing two runs (one earned) on five hits with seven strikeouts and two walks in 7.0 innings.

This year, the Angels average 4.36 runs per game (15th in the MLB) on a .234/.305/.408 triple-slash. When it comes to pitching, the Angels’ staff has a 4.60 ERA (26th) and 1.43 WHIP (29th). Taylor Ward leads the Angels with a .232 batting average, 25 home runs, and 78 RBI this season.

The projected starting pitcher for the Angels is Tyler Anderson, who is 2-6 in 21 starts this season, with a 4.41 ERA and 1.41 WHIP in 112.1 innings.

Why the Angels will beat the White Sox

  • The Angels have won each of their last 10 night games following a home loss.
  • The White Sox have lost each of their last eight road games against American League opponents that held a losing record.
  • The Angels have covered the run line in each of their last eight home games against American League opponents following a home loss.
  • The White Sox have failed to cover the run line in seven of their last eight games as underdogs following a home win.
  • The White Sox have trailed after 3 innings in four of their last five road games against AL West opponents.
  • The White Sox have trailed after 5 innings in four of their last five games against AL West opponents that held a losing record.

Total Runs Facts

  • Seven of the Angels’ last eight games as favorites against the White Sox have gone UNDER the total runs line.
  • Fifteen of the White Sox’s last 20 road games against American League opponents have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Angels’ last eight games as favorites.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the White Sox’s last five games.

Matchup/League Facts

  • The Angels rank T28th in the league for doubles this season (150).
  • The Angels rank 4th in the league for home runs this season (155).
  • The White Sox rank 29th in the league for slugging percentage this season (.365).
  • The White Sox rank 29th in the league for on-base percentage this season (.299).

White Sox vs Angels Prediction

The White Sox won six of the previous ten H2H encounters, but the Angels won two of three meetings this season. The White Sox will probably turn to their bullpen for this game, which doesn’t have to be a bad thing, considering the Sox have a solid bullpen that allows a 3.88 ERA per game. Still, I usually bet against the teams that don’t announce a starter one day before the game, and I am not going to change that strategy in this one. Tyler Alexander, on the other hand, wasn’t bad in his recent starts, and I am sure he can contain the White Sox to two or three runs here. Alexander will have to last as much as he can, because unlike the White Sox’s, the Angels’ bullpen is rather weak. I am going with the Halos.

Oliver Zivic's Pick: Angels ML

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