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Chicago White Sox vs Kansas City Royals Prediction 9/24/2026 Today’s MLB Picks

Sep 22, 2026; Kansas City, Missouri, USA;  Chicago White Sox first baseman Munetaka Murakami (5) slaps hands with Chicago White Sox catcher Kyle Teel (8) after hitting a home run during the sixth inning against the Kansas City Royals at Kauffman Stadium.  Mandatory Credit: William Purnell-Imagn Images

Sep 22, 2026; Kansas City, Missouri, USA; Chicago White Sox first baseman Munetaka Murakami (5) slaps hands with Chicago White Sox catcher Kyle Teel (8) after hitting a home run during the sixth inning against the Kansas City Royals at Kauffman Stadium. Mandatory Credit: William Purnell-Imagn Images

MATCHUP Chicago White Sox Kansas City Royals
Team Records 81-77 68-90
Spread -1.5 134 +1.5 -163
Moneyline -125 +104
Total Over 8.5 (-122) Under 8.5 (102)
Where Kauffman Stadium, Kansas City, Missouri
When Thursday, September 24, 2026
Time 02:10 PM EDT
TV MLB.TV
The Chicago White Sox and Kansas City Royals meet Thursday in MLB action at Kauffman Stadium. Here’s a Chicago White Sox vs. Kansas City Royals Prediction. This article will include a Chicago White Sox vs. Kansas City Royals Pick.

Chicago White Sox Betting Preview


The Chicago White Sox are 81-77 on the year and play the Rockies next. The Chicago White Sox are batting .235 on the season, have a .320 OBP, and have a .404 slugging percentage. The Chicago White Sox pitching staff has a 4.15 ERA and a 1.32 WHIP. Chase Meidroth leads the Chicago White Sox with 151 hits and 63 RBI, while Sam Antonacci and Miguel Vargas have combined for 268 hits and 137 RBI.

David Sandlin gets the ball for the Chicago White Sox, and he is 2-2 with a 6.29 ERA and 33 strikeouts this season. This will be Sandlin’s second career game against the Kansas City Royals.

Kansas City Royals Betting Preview


The Kansas City Royals are 68-90 on the year and play the Guardians next. The Kansas City Royals are batting .246 on the season, have a .315 OBP, and have a .399 slugging percentage. The Kansas City Royals’ pitching staff has a 4.72 ERA and a 1.40 WHIP. Bobby Witt Jr. leads the Kansas City Royals with 152 hits and 54 RBI, while Salvador Perez and Jac Caglianone have combined for 268 hits and 145 RBI.

Randy Dobnak gets the ball for the St. Louis Cardinals, and he is 3-4 with a 3.08 ERA and 48 strikeouts this season. Dobnak is 0-2 with a 5.25 ERA and 9 strikeouts in his career against the Chicago White Sox.

Why the Kansas City Royals will win

Why the Chicago White Sox will win

Total Runs Facts

Kansas City Royals Player Prop Facts

Chicago White Sox Player Prop Facts

Matchup/League Facts

Chicago White Sox vs Kansas City Royals Prediction


The Royals probably have the edge in this spot with Dobnak on the mound as he has a 3.08 ERA and 1.33 WHIP through 73 innings. Sandlin has been a mess through 34.1 frames with a 6.29 ERA and 1.28 WHIP. However, I’ve been on the White Sox all season, and they continue to turn a profit. They’re also fighting for a division title. How you can get the White Sox at a price this cheap against a bad team in the Royals is beyond me. Oddsmakers really don’t like the White Sox. Give me the White Sox in a game they need to win.

Randy Chambers's Pick: Chicago White Sox

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