Chicago White Sox vs Detroit Tigers Prediction 4/6/25 MLB Picks

In this article we will formulate a Chicago White Sox vs Detroit Tigers prediction for this MLB game on Sunday, April 6th at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 2-6 this year after they lost game two in this series by a score of 7-2 on Saturday. Chicago led 1-0 in the first inning, but they allowed the next seven runs and never got back into the game. The White Sox recorded eight hits in the game and they were led by Vaughn, who went 1-3 with one RBI and one walk in the loss. Chicago started Martin, who allowed nine hits and seven earned runs over 5.0 innings, while Ellard, Booser, and Leasure allowed zero earned runs over three innings. 

Prior to this series, the White Sox lost two out of three against the Twins and two out of three against the Angels. The Chicago pitching staff has a 3.99 ERA with a 1.23 WHIP and a .227 opponent batting average, while their offense has scored 29 runs with a .217 batting average and a .277 on base percentage this season. Andrew Benintendi has led Chicago with two home runs and six RBIs, while Brooks Baldwin has added one home run and five RBIs so far this year. The projected starting pitcher for Chicago is Martin Perez, who is 1-0 with a 0.00 ERA and a 0.50 WHIP over 6.0 innings pitched this season. 

Detroit Tigers Betting Preview

The Detroit Tigers are 4-4 this season after they won games one and two in this series by scores of 7-4 and 7-2. In the game two win, Detroit scored seven runs in a row between the first and third innings, and they cruised to the easy win. The Tigers recorded 10 hits in the game and they were led by Carpenter, who went 1-5 with one home run and two RBIs in the win. Detroit started Olson, who allowed seven hits and two earned runs over 6.0 innings pitched in the win, while Brieske and Brebbia allowed zero earned runs over the final three innings. 

Prior to this series, the Tigers won two out of three against the Mariners and were swept by the Dodgers. The Detroit pitching staff has a 4.54 ERA with a 1.13 WHIP and a .206 opponent batting average, while their offense has scored 41 runs with a .274 batting average and a .353 on base percentage this season. Kerry Carpenter has led Detroit with three home runs and eight RBIs, while Dillon Dingler has added one home run and six RBIs this year. The projected starting pitcher for Detroit is Jackson Jobe, who is 0-0 with a 6.75 ERA and a 1.75 WHIP over 4.0 innings pitched this season. 

Why the Tigers will beat the White Sox 

• The White Sox have lost 17 of their last 19 games against AL Central opponents following a loss.
• The Tigers have won eight of their last 10 games against AL Central opponents that held a losing record.
• The White Sox have failed to cover the run line in eight of their last nine games as road underdogs against AL Central opponents following a loss.
• The Tigers have covered the run line in each of their last four games at Comerica Park.
• The White Sox have trailed after 5 innings in each of their last three games against American League opponents.
• The White Sox have lost the first inning in each of their last three games as underdogs against AL Central opponents.
• The White Sox have trailed after 3 innings in each of their last three games against American League opponents.

Total Runs Facts

• Five of the White Sox’s last six games as underdogs against AL Central opponents have gone OVER the total runs line.
• Eight of the Tigers’ last 10 games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last five day games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Tigers’ last four games at Comerica Park.

Detroit Tigers Player Prop Facts

• Riley Greene has recorded a Double in three of the Tigers’ last four games against AL opponents.
• Riley Greene has recorded an RBI in each of the Tigers’ last five games against AL opponents.
• Kerry Carpenter has hit at least one home run in each of the Tigers’ last three games as home favorites.
• Gleyber Torres has recorded at least one Single in each of his last seven appearances against AL opponents that held a losing record.
• Gleyber Torres has recorded at least one hit in each of his last 10 home appearances against AL opponents that held a losing record.
• Gleyber Torres has scored at least one run in each of his last six home appearances against AL opponents.

Chicago White Sox Player Prop Facts

• Martin Perez has recorded five or more strikeouts in each of his last three appearances against AL Central opponents.
• Nick Maton has hit a home run in three of his last seven appearances after playing the previous day.
• Andrew Benintendi has recorded at least one Single in each of the White Sox’s last four games as underdogs.
• Andrew Benintendi has recorded at least one hit in each of his last six appearances against AL Central opponents.
• Luis Robert has scored a run in four of his last five appearances with the White Sox as underdogs against the Tigers.

Chicago White Sox vs Detroit Tigers Prediction 

Detroit rolls into this matchup looking to complete the sweep and they have scored 14 runs in the first two games of this series. The Tigers have also pitched well over their last four games and will turn to Jackson Jobe, who I think will have a much better outing in his second career start. Chicago has lost four games in a row and they have allowed 28 runs in those four games. The White Sox will give the ball to Martin Perez, who was great against the Twins in his first start, but will face a Detroit team that is red hot at the plate. Take the Tigers -1.5 here. 

David Racey's Pick: Tigers -1.5