Chicago White Sox vs Detroit Tigers Prediction 4/4/25 MLB Picks

In this article we will formulate a Chicago White Sox vs Detroit Tigers prediction for this MLB game on Friday, April 4th at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 2-4 this year after they lost two out of three against Minnesota in their last series by scores of 9-0, 3-8, and 1-6. In game three of that series, Chicago allowed the first six runs in the game, but did get on the scoreboard in the seventh inning to avoid the shutout. The White Sox recorded six hits in the game and they did commit one error, while being led by Baldwin, who went 1-3 with one home run in the loss. Chicago started Burke, who allowed seven hits and six earned runs over 4.1 innings for the loss. 

Prior to that series, the White Sox opened the season by losing two out of three against the Angels by scores of 8-1, 0-1, and 2-3. The Chicago pitching staff has a 2.83 ERA with a 1.06 WHIP and a .201 opponent batting average, while their offense has scored 23 runs with a .214 batting average and a .268 on base percentage this season. Andrew Benintendi has led Chicago with two home runs and six RBI’s, while Brooks Baldwin and Andrew Vaughn both have one home run and three RBI’s this year. The projected starting pitcher for Chicago is Jonathan Cannon, who is 0-0 with a 0.00 ERA and a 1.40 WHIP over 5.0 innings pitched this season. 

Detroit Tigers Betting Preview

The Detroit Tigers are 2-4 this season after they won two out of three against Seattle earlier this week by scores of 9-6, 4-1, and 2-3. In the last game of that series, the Tigers fell behind 3-0 in the fourth inning, but they did battle back, before leaving the bases loaded in the ninth. Detroit recorded six hits in the game and they were led by Sweeney, who went 1-4 with one home run, but also failed to lay down a crucial bunt in the ninth. The Tigers started Skubal, who allowed six hits and three earned runs over 5.2 innings of work, while Hanifee and Brebbia combined for 2.1 shutout innings in relief.

Prior to that series, the Tigers were swept by the Dodgers by scores of 4-5, 5-8, and 3-7. The Detroit pitching staff has a 5.08 ERA with a 1.09 WHIP and a .198 opponent batting average, while their offense has scored 27 runs with a .265 batting average and a .336 on base percentage this season. Dillon Dingler has led Detroit with one home run and five RBI’s, while Kerry Carpenter has added four RBI’s so far this year. The projected starting pitcher for Detroit is Jack Flaherty, who is 0-0 with a 3.18 ERA and a 0.88 WHIP over 5.2 innings pitched this season. 

Why the Tigers will beat the White Sox 

• The White Sox have lost each of their last 10 Friday day games against AL Central opponents.
• The Tigers have won each of their last six games against American League opponents following a road loss.
• The Tigers have covered the run line in nine of their last 10 games against American League opponents following a road loss.
• The White Sox have failed to cover the run line in eight of their last nine games against AL Central opponents following a home loss.
• The White Sox have trailed after 5 innings in four of their last five games at Comerica Park against AL Central opponents that held a losing record.
• The White Sox have trailed after 3 innings in four of their last five games at Comerica Park against opponents that held a losing record.

Total Runs Facts

• Seven of the last nine games between the White Sox and Tigers at Comerica Park have gone UNDER the total runs line.
• Six of the White Sox’s last eight day games against AL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last eight games as road underdogs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last seven games as favorites against American League opponents.

Detroit Tigers Player Prop Facts

• Riley Greene has recorded an RBI in each of the Tigers’ last three games against AL opponents.
• Jack Flaherty has recorded a win in each of his last four appearances against opponents that held a losing record.
• Jack Flaherty has recorded seven or more strikeouts in each of his last five appearances at Comerica Park against opponents that held a losing record.
• Gleyber Torres has recorded at least one hit in each of his last 10 home appearances against AL opponents that held a losing record.
• Javier Baez has hit a home run in two of his last three home appearances with the Tigers against AL opponents.
• Gleyber Torres has recorded at least one Single in each of his last seven appearances against AL opponents that held a losing record.
• Gleyber Torres has scored at least one run in each of his last six home appearances against AL opponents.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has hit at least one home run in three of the White Sox’s last five road games against opponents that held a losing record.
• Andrew Benintendi has recorded at least one RBI in five of the White Sox’s last six road games against AL opponents that held a losing record.
• Andrew Vaughn has scored a run in four of his last five appearances in day games against AL teams that held a losing record.
• Andrew Benintendi has recorded at least one hit in each of his last seven appearances against AL opponents that held a losing record.
• Mike Tauchman has recorded a Single in each of his last six Friday day appearances against teams that held a losing record.

Chicago White Sox vs Detroit Tigers Prediction 

Detroit finally comes home for their Opening Day at Comerica Park, but they had a rough road trip out West, as they lost four out of six games to the Dodgers and Mariners. The Tigers offense was actually pretty decent when it comes to hitting the ball, but they need improvement with runners in scoring position. Chicago is also 2-4 to start the season, but they allowed 14 runs in their last two games against the Twins. I do like both starting pitchers in this game, but I think Flaherty and this Tigers offense should roll to an impressive win. Take the Tigers -1.5 here. 

David Racey's Pick: Tigers -1.5