Chicago White Sox vs Detroit Tigers Prediction 9/5/2025 Today’s MLB Picks

The Chicago White Sox and Detroit Tigers meet Friday in MLB action at Comerica Park. Here’s a Chicago White Sox vs Detroit Tigers Prediction. This article will include a Chicago White Sox vs Detroit Tigers Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 53-88 on the year and play the Rays, Guardians, and Orioles next. The Chicago White Sox are batting .235 on the season, have a .304 OBP, and a .378 slugging percentage. The Chicago White Sox pitching staff has a 4.23 ERA and a 1.37 WHIP. Lenyn Sosa leads the Chicago White Sox with 119 hits and 62 RBI, while Miguel Vargas and Chase Meidroth have combined for 200 hits and 73 RBI.

Shane Smith gets the ball for the Chicago White Sox, and he is 4-7 with a 3.81 ERA and 112 strikeouts this season. Smith is 1-0 with a 0.00 ERA and 11 strikeouts in his career against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 81-60 on the year and play the Yankees, Marlins, and Guardians next. The Detroit Tigers are batting .251 on the season, have a .320 OBP, and a .422 slugging percentage. The Detroit Tigers pitching staff has a 3.89 ERA and a 1.24 WHIP. Riley Greene leads the Detroit Tigers with 141 hits and 103 RBI while Gleyber Torres and Spencer Torkelson have combined for 235 hits and 134 RBI.

Jack Flaherty gets the ball for the Detroit Tigers, and he is 7-13 with a 4.74 ERA and 169 strikeouts this season. Flaherty is 3-2 with a 3.45 ERA and 35 strikeouts in his career against the Chicago White Sox.

The Chicago White Sox @ Detroit Tigers Betting Trends: September 5, 2025

• Probable Starting Pitcher: Jack Flaherty      Record this season: 7-13      ERA: 4.74
• Home Record: 5-7
• Last 5 against White Sox: 3-1

Why the Detroit Tigers will win

• The White Sox have lost seven of their last eight games against the Tigers following a win.
• The Tigers have won six of their last seven night games against AL Central opponents.
• The White Sox have failed to cover the run line each of their last four night games against American League opponents that held a winning record.
• The Tigers have covered the run line in five of their last six night games against AL Central opponents.
• The Tigers have led after 5 innings in each of their last three night games against the White Sox at Comerica Park.

• Probable Starting Pitcher: Shane Smith      Record this season: 4-7      ERA: 3.81
• Road Record: 2-4
• Last 5 against Tigers: 1-0

Why the Chicago White Sox will win

• The underdogs have won each of the White Sox’s last five games.
• The Tigers have lost five of their last six games as favorites against American League opponents.
• The White Sox have covered the run line in each of their last 10 games as underdogs following a win.
• The Tigers have failed to cover the run line each of their last four games against American League opponents that held a losing record.
• The Tigers have trailed after 5 innings in four of their last five games at Comerica Park against opponents that held a losing record.
• The Tigers have trailed after 3 innings in three of their last four games against American League opponents that held a losing record.

Total Runs Facts

• Eleven of the Tigers’ last 13 home games against American League opponents have gone OVER the total runs line.
• Five of the White Sox’s last six games as underdogs against AL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the Tigers’ last 11 games as favorites against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the White Sox’s last seven night games at Comerica Park.

Detroit Tigers Player Prop Facts

• Kerry Carpenter has hit a home run in four of the Tigers’ last five games at Comerica Park against AL Central opponents that held a losing record.
• Jack Flaherty has recorded a win in three of his last four appearances against the White Sox.
• Jack Flaherty has recorded seven or more strikeouts in 11 of his last 14 appearances with the Tigers as home favorites against AL opponents.
• Spencer Torkelson has recorded at least one hit in each of the Tigers’ last 14 games at Comerica Park against AL Central opponents that held a losing record.

Chicago White Sox Player Prop Facts

• Andrew Benintendi has recorded at least one hit in each of his last six appearances in night games against teams that held a winning record.

Matchup/League Facts

• The Tigers rank 26th in the league for strikeouts against this season (1242).
• The Tigers rank 8th in the league for runs scored this season (680).
• The White Sox rank 27th in the league for hits this season (1106).
• The White Sox rank T27th in the league for triples this season (9).

Chicago White Sox vs Detroit Tigers Prediction

The White Sox are piling up the wins this week, and it makes them worth a look here as well with an all-star on the mound. Smith isn’t winning games much due to a lack of run support, but he’s allowed 19 hits and 10 runs in his last 33.2 innings. Flaherty hasn’t been himself lately, which includes allowing 35 hits and 20 earned runs in his last 32.2 innings. The Tigers have lost 5 of Flaherty’s last 6 starts. This winning stretch for the White Sox won’t last much longer, but I’ll take a stab with them for one more game.