Chicago White Sox vs Cleveland Guardians Prediction 9/15/2026 Today’s MLB Picks
Chris Ruffolo
Sep 6, 2026; Chicago, Illinois, USA; Chicago White Sox first baseman Munetaka Murakami (5) warms up before the game against the Minnesota Twins at Rate Field. Mandatory Credit: Matt Marton-Imagn Images
MATCHUP
Chicago White Sox
Cleveland Guardians
Team Records
77-73
76-75
Spread
+1.5 -175
-1.5 144
Moneyline
+128
-155
Total
Over 8.5 (-111)
Under 8.5 (-108)
Where
Progressive Field, Cleveland, Ohio
When
Tuesday, September 15, 2026
Time
06:40 PM EDT
TV
ESPN Unlmtd
The Chicago White Sox and the Cleveland Guardians meet Tuesday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Cleveland Guardians prediction.
Starting Pitching Matchup
The Chicago White Sox will send out Davis Martin for the start here and Martin is 9-7 with a 4.05 ERA and 115 strikeouts this season. Foster Griffin will start for the Guardians and is 15-5 with a 3.65 ERA and 146 strikeouts this season.
Chicago White Sox Recap
The Chicago White Sox come into this game looking to add on to their 7-3 win over the Guardians on Monday to sit at 77-73 this season. After this series, Chicago will head home for a series against the Detroit Tigers.
White Sox Alternate Wins & Losses In 4 Straight
Entering Monday, Munetaka Murakami has 84 hits with 31 home runs and 65 RBIs while Miguel Vargas has 135 hits with 30 doubles, a triple, 30 home runs and 79 RBIs and Colson Montgomery has 109 hits with 23 doubles, 31 home runs and 84 RBIs. Luisangel Acuna has 46 hits and Tristan Peters has 114 hits with 31 doubles, 12 home runs and 54 RBIs so far this season. Chase Meidroth also has 140 hits with 27 doubles, 14 home runs and 54 RBIs this year.
Cleveland Guardians Recap
The Cleveland Guardians come into this game looking to bounce back from their loss to Chicago last time out to sit at 76-75 this season. After this series, the Guardians will take on the Athletics at home.
Guardians Also Looking For Consistency
Going into Monday, Chase DeLauter has 134 hits with 28 doubles, 14 home runs and 62 RBIs while Steven Kwan has 139 hits with 21 doubles, 3 home runs and 30 RBIs and Jose Ramirez has 98 hits with 24 doubles, 11 home runs and 48 RBIs this season. Brayan Rocchio has also added 123 hits with 21 doubles, 13 home runs and 65 RBIs this season while Angel Martinez has 89 hits with 21 doubles, 15 homers and 53 RBIs and Rhys Hoskins has added 47 hits with 13 doubles, 13 home runs and 38 RBIs. Daniel Schneemann has 53 hits with 11 doubles, 6 home runs and 29 RBIs this season.
The Chicago White Sox @ Cleveland Guardians Betting Trends: September 15, 2026
Probable Starting Pitcher: Foster Griffin Record this season: 15-5 ERA: 3.65
Home Record: 7-2
Last 5 against White Sox: 0-0
Why the Cleveland Guardians will win
The Guardians have won 11 of their last 12 night games against the White Sox at Progressive Field following a loss.
The White Sox have lost nine of their last 10 night games at Progressive Field following a win.
The White Sox have failed to cover the run line in nine of their last 10 night games at Progressive Field following a win.
The Guardians have covered the run line in eight of their last nine night games against the White Sox following a home loss.
Probable Starting Pitcher: Davis Martin Record this season: 9-7 ERA: 4.05
Road Record: 4-5
Last 5 against Guardians: 1-2
Why the Chicago White Sox will win
The White Sox have won eight of their last nine games as underdogs against AL Central opponents.
The Guardians have lost eight of their last nine games against AL opponents that held a winning record.
The White Sox have covered the run line each of their last nine games against AL Central opponents that held a winning record.
The Guardians have failed to cover the run line in each of their last seven home games.
The Guardians have trailed after 5 innings in four of their last five night games against AL Central opponents.
The Guardians have trailed after 3 innings in six of their last seven games as favorites.
Total Runs Facts
Seven of the White Sox’s last eight night games against AL Central opponents have gone OVER the total runs line.
Five of the Guardians’ last six games after playing the previous day have gone OVER the total runs line.
There has been no run scored during the first inning in five of the White Sox’s last six games.
There has been no run scored during the first inning in four of the Guardians’ last five night games against AL Central opponents.
Cleveland Guardians Player Prop Facts
Foster Griffin has recorded a win in four of his last five appearances in night games against teams that held a winning record.
Steven Kwan has recorded at least one hit in each of his last 14 appearances in night games against teams that held a winning record.
Austin Hedges has hit a home run in two of his last three home appearances against AL opponents that held a winning record.
Foster Griffin ranks T3rd in the league for Wins (15) this season.
Chicago White Sox Player Prop Facts
Colson Montgomery has hit a home run in two of the White Sox’s last three road games against the Guardians.
Davis Martin has recorded three or more strikeouts in 23 of his last 25 appearances in night games against teams that held a winning record.
Randal Grichuk has recorded at least one hit in each of his last seven appearances.
Matchup/League Facts
The Guardians rank 30th in the league for home runs this season (143).
The Guardians rank 29th in the league for slugging percentage this season (.374).
The White Sox rank 26th in the league for hits this season (1180).
The White Sox rank 26th in the league for batting average this season (.235).
Chicago White Sox vs. Cleveland Guardians Prediction
I’m on the under here. I think that Griffin is one of the starters in the Guardians rotation with more upside, but on the other side, Martin has been pitching well in his recent starts as well and I think with this series meaning so much for both teams playoff hopes, I think the under cashes here. Give me the under in this one.
