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Chicago White Sox vs Chicago Cubs Prediction 07/26/2025 Picks

Jul 19, 2025; Chicago, Illinois, USA; Chicago Cubs outfielder Kyle Tucker (30) gestures after hitting a home run against the Boston Red Sox during the first inning at Wrigley Field. Mandatory Credit: David Banks-Imagn Images

Jul 19, 2025; Chicago, Illinois, USA; Chicago Cubs outfielder Kyle Tucker (30) gestures after hitting a home run against the Boston Red Sox during the first inning at Wrigley Field. Mandatory Credit: David Banks-Imagn Images

MATCHUP Chicago Cubs Chicago White Sox
Team Records 61-43 38-67
Where Rate Field, Chicago, Illinois
When Saturday, July 26, 2025
Time 07:10 PM EDT
TV MLB.TV

The Chicago Cubs and the Chicago White Sox meet Saturday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Chicago Cubs will send out Cade Horton for the start here and Horton is 3-3 with a 4.04 ERA and 47 strikeouts this season. This will be Horton’s second career start against the White Sox. The Chicago White Sox will send out Aaron Civale for the start here and Civale is 2-6 with a 4.76 ERA and 42 strikeouts this season. In his career, Civale is 0-0 with a 1.61 ERA and 16 strikeouts against the Cubs.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to rebound from a 12-5 loss at the hands of the White Sox in Friday’s series opener to sit at 60-43 on the year. After this series, the Cubs will head on the road for a huge division series against the Milwaukee Brewers.

Cubs Lose 4 Of Their Last 5 Games

Ian Happ has 83 hits with 16 doubles, 13 home runs and 48 RBIs. Kyle Tucker has 103 hits including 19 doubles, 4 triples, 18 home runs and 58 RBIs while Seiya Suzuki also has 100 hits with 24 doubles and 26 home runs and 81 RBIs of his own. Pete Crow-Armstrong also has contributed 106 hits, 25 doubles, 4 triples, 27 home runs and 74 RBIs as well this season. Dansby Swanson has added 16 home runs and 47 RBIs, while also having 115 strikeouts and Suzuki has a team-high 114 strikeouts so far this season. Crow-Armstrong also has a team-high 28 stolen bases while Nico Hoerner has 19 stolen bases this season. Tucker’s also added 23 stolen bases while Michael Busch has also chipped in 15 doubles, 3 triples, 20 home runs and 60 RBIs this season.

Why the Chicago Cubs will win

Chicago Cubs Player Prop Facts

Chicago White Sox Recap

The Chicago White Sox come into this game looking to add on to their win over the Cubs from Friday’s matchup to sit at 38-66 this season. After this series, the White Sox will square off against the Philadelphia Phillies at home.

White Sox Win 6 Of Their Last 7 Games

Lenyn Sosa has 83 hits including 16 doubles and 37 RBIs. Andrew Benintendi has 62 hits including 12 doubles, 11 home runs, 38 RBIs and a .235 batting average while Miguel Vargas has 84 hits, 25 doubles, 12 home runs and 41 RBIs. Brooks Baldwin has also added 24 RBIs while Luis Robert Jr. has a team-high 26 stolen bases along with 41 RBIs so far this season. Chase Meidroth has added 75 hits with 11 stolen bases as well as 11 doubles this season.

Why the Chicago White Sox will win

Chicago White Sox Player Prop Facts

Total Runs Facts

Chicago Cubs vs. Chicago White Sox Prediction

I’m on the over in this one. I don’t trust either one of these starting pitching options in honesty, as the White Sox are playing their best ball of the season and Cade Horton doesn’t look major league ready, while the Cubs are still a strong team and Aaron Civale’s been prone to giving up home runs not just this season, but overall in his career. I think we get some runs here as well, so give me the over.

Chris Ruffolo's Pick: Over 9.5

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