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Chicago White Sox vs Athletics Prediction 4/25/25 MLB Picks

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Athletics (12-13) vs Chicago White Sox (6-19)

Game Info: Friday, April 25, 2025 at 10:05 pm (Sutter Health Park)

The Line: Betting Odds: Athletics -230 / Chicago White Sox +190 — Over/Under: 9

(Get latest betting odds)

The Chicago White Sox and Athletics meet Friday in MLB action at Sutter Health Park. Here’s a Chicago White Sox vs Athletics Prediction. This article will include a Chicago White Sox vs Athletics Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 6-19 on the year and play the Brewers, Astros, and Royals next. The Chicago White Sox are batting .203 on the season, have a .279 OBP, and a .310 slugging percentage. The Chicago White Sox pitching staff has a 4.21 ERA and a 1.38 WHIP. Lenyn Sosa leads the Chicago White Sox with 22 hits and 6 RBI, while Brooks Baldwin and Andrew Vaughn have combined for 31 hits and 20 RBI. 

Sean Burke gets the ball for the Chicago White Sox, and he is 1-3 with a 6.23 ERA and 15 strikeouts this season. Burke is 1-1 with a 7.56 ERA and 7 strikeouts in his career against the Athletics.

Athletics Betting Preview

The Athletics are 12-13 on the year and play the Rangers, Marlins, and Mariners next. The Athletics are batting .254 on the season, have a .313 OBP, and a .432 slugging percentage. The Athletics pitching staff has a 4.46 ERA and a 1.45 WHIP. Jacob Wilson leads the Athletics with 31 hits and 12 RBI while Tyler Soderstrom and Lawrence Butler have combined for 54 hits and 28 RBI.

Luis Severino gets the ball for the Athletics, and he is 1-3 with a 3.31 ERA and 22 strikeouts this season. Severino is 2-3 with a 4.43 ERA and 47 strikeouts in his career against the Chicago White Sox.

Why the Athletics will win

Why the Chicago White Sox will win

Athletics Player Prop Facts

Chicago White Sox Player Prop Facts

Chicago White Sox vs Athletics Prediction

The Chicago White Sox have won two games in a row just once this season and Burke isn’t somebody I’m excited to back. Through 21.2 innings, Burke has allowed 24 hits and 15 earned runs. The Athletics already tagged Burke for six hits and five runs in 3.1 innings this season. The Athletics are coming off a nice series win over the Rangers, and Severino has allowed seven hits and two runs in his last 13.2 innings. Severino hasn’t pitched well in Sacramento this year, but he’s a veteran who should figure it out sooner than later. The price is insane given these are two below-average teams. Still, give me the Athletics, and I’ll lay the RL to shave down the price. 

Randy Chambers's Pick: Athletics -1.5

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