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Chicago Cubs vs Tampa Bay Rays Prediction 4/6/2026 Today’s MLB Picks

Oct 8, 2025; Chicago, Illinois, USA; Chicago Cubs pitcher Jameson Taillon (50) reacts after throwing against the Milwaukee Brewers in the fourth inning during game three of the NLDS round for the 2025 MLB playoffs at Wrigley Field. Mandatory Credit: Matt Marton-Imagn Images

Oct 8, 2025; Chicago, Illinois, USA; Chicago Cubs pitcher Jameson Taillon (50) reacts after throwing against the Milwaukee Brewers in the fourth inning during game three of the NLDS round for the 2025 MLB playoffs at Wrigley Field. Mandatory Credit: Matt Marton-Imagn Images

MATCHUP Chicago Cubs Tampa Bay Rays
Team Records 4-5 4-5
Spread -1.5 159 +1.5 -193
Moneyline +100 -120
Total Over 8 (-104) Under 8 (-116)
Where George M. Steinbrenner Field, Tampa, Florida
When Monday, April 6, 2026
Time 04:10 PM EDT
TV MLB.TV

In this article, we will formulate a Cubs vs Rays Prediction for this MLB matchup on Monday, April 6th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Tampa Bay Rays Preview

The Tampa Bay Rays have a 4-5 record this season and are sitting in the second place of the AL East. They have a 0-0 home record and are coming off a 4-1 road win against the Twins. Their previous three games were a 7-1 road win and a 4-10 road loss against the Twins, and a 2-8 road loss against the Brewers.

The Rays have a .265 batting average this season, .342 OBP and .391 Slugging percentage. Tampa Bay’s pitching staff has a 4.71 ERA and 1.17 WHIP. Yandy Diaz is the team’s best hitter with a .405 batting average, also leading the team in RBI with 10 and adding a team-high two home runs.

Shane McClanahan (L) is the projected starting pitcher for the Rays, and he has a 0-1 record, 3.86 ERA and 1.07 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 4-5 record this season and are sitting in the last place of the NL Central. They have a 1-2 road record and are coming off a 5-6 road loss against the Guardians. Their previous three games were a 1-0 road win and a 1-4 road loss against the Guardians, and a 6-2 home win against the Angels.

The Cubs have a .206 batting average this season, .304 OBP and .334 Slugging percentage. Chicago’s pitching staff has a 3.53 ERA and 1.16 WHIP. Nico Hoerner is the team’s best hitter with a .276 batting average. Ian Happ leads the team in RBI with 7, also adding a team-high four home runs.

Jameson Taillon (R) is the projected starting pitcher for the Cubs, and he has a 0-0 record, 0.00 ERA and 1.29 WHIP.

The Chicago Cubs @ Tampa Bay Rays Betting Trends: April 6, 2026

Why the Tampa Bay Rays will win

Why the Chicago Cubs will win

Total Runs Facts

Tampa Bay Rays Player Prop Facts

Chicago Cubs Player Prop Facts

Matchup/League Facts

Cubs vs Rays Prediction

The Cubs won their only series against the Rays last season by 2-1 at home and both teams are tied 5-5 in their last 10 meetings.  

In this Cubs vs Rays Prediction, both teams are coming at a pickem price. The Rays have back-to-back wins against the Twins with a combined 11-2 score and are playing their home opener. They are putting Shane McClanahan who had a decent first start this season and he goes up against Jameson Taillon, who started the season with a shutout for the Cubs. The Rays have by far the weakest bullpen in baseball so far, by they are far better against right-handed pitching, while the Cubs are weaker against lefties, so I will take the Rays to win their home opener today.

Nikos Lagouretos's Pick: Tampa Bay Rays ML

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