Chicago Cubs vs St. Louis Cardinals Prediction 8/8/2025 Today’s MLB Picks

In this article, we will formulate a Chicago Cubs vs Pittsburgh Pirates Prediction for this MLB game on Friday, August 8th at the Busch Stadium in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 58-58 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 32-24 home record and are 58-52 in over/under They are coming off a 5-3 road victory over the Dodgers, and are 3-5 in their last 8 games. Under is 5-3 in their last 8 games and are playing the Rockies and the Yankees next.

The Cardinals have a .249 batting average this season, .319 OBP and .388 Slugging percentage. Saint Louis’ pitching staff has a 4.22 ERA and 1.29 WHIP. Brendan Donovan leads the Cardinals with 115 hits, and he is the team’s best hitter with a .280 batting average. Wilson Contreras leads the team in RBI, with 64, adding a team-high 16 home runs.

Michael McGreevy (R) is the projected starting pitcher for the Cardinals, and he has a 3-2 record, 5.08 ERA and 1.23 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 66-48 record this season and are sitting on the second place of the NL Central. The Cubs have a 30-26 road record and are 55-49 in over/under. They are coming off a 6-1 home victory over the Reds, which ended their previous two-game losing streak. Under is 5-0-1 in their last 6 games, and are playing the Blue Jays and the Pirates next.

The Cubs have a .253 batting average this season, .323 OBP and .449 Slugging percentage. Chicago’s pitching staff has a 3.89 ERA and 1.22 WHIP. Nico Hoerner leads the Cubs with 122 hits, and he is the team’s best hitter with a .292 batting average. Seiya Suzuki leads the team in RBI, with 84, adding a team-high 27 home runs.

Matthew Boyd (R) is the projected starting pitcher for the Cubs, and he has a 11-4 record, 2.34 ERA and 1.03 WHIP.

Why the St. Louis Cardinals will win

• The Cubs have lost six of their last seven games as favorites against the Cardinals following a home win.
• The underdogs have won five of the Cardinals’ last six games at Busch Stadium.
• The Cubs have failed to cover the run line in each of their last seven games following a win.
• The underdogs have covered the run line in five of the Cardinals’ last six games at Busch Stadium.
• The Cubs have trailed after 5 innings in each of their last six Friday night games.
• The Cubs have trailed after 3 innings in eight of their last nine road night games.

Why the Chicago Cubs will win

• The Cardinals have lost each of their last six games against the Cubs following a road win.
• The Cubs have won each of their last five night games against the Cardinals following a win.
• The Cardinals have failed to cover the run line in 11 of their last 12 games against National League opponents following a win.
• The Cubs have covered the run line in four of their last five games against the Cardinals.
• The Cubs have led after 5 innings in four of their last five games against the Cardinals.
• The Cardinals have lost the first inning in three of their last four night games against NL Central opponents.
• The Cubs have led after 3 innings in six of their last seven games.

Total Runs Facts

• Each of the Cubs’ last four road games have gone OVER the total runs line.
• Each of the Cardinals’ last three games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last five night games at Busch Stadium.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Cubs’ last six games.

Matchup/League Facts

The Cubs rank 2nd in the league for runs scored this season (588).

The Cardinals rank 30th in the league for triples this season (4).

The Cardinals rank 29th in the league for strikeouts this season (839).

The Cubs rank 1st in the league for RBIs this season (573).

Chicago Cubs vs Saint Louis Cardinals Prediction

The Cubs are 4-1 in their last 5 head-to-head meetings against the Cardinals, and are 4-3 in their 7 meetings this season. Over is 7-3 in their last 10 meetings.
In this Chicago Cubs vs Saint Louis Cardinals Prediction, the Cubs are coming as -150 road favorites. Both teams have been up and down lately, but I am not the Cubs in this one, as they have a huge pitching advantage. Boyd has been excellent this season, and has been lights out lately, with four shutouts in his last five starts. He has shut out the Cardinals twice this season, while McGreevy has been terrible at home for the Cardinals, with a 6.86 ERA. Take the Cubs on the runline in the first 5 innings of this game.