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Chicago Cubs vs St. Louis Cardinals Prediction 7/27/2026 Today’s MLB Picks

Jun 26, 2025; St. Louis, Missouri, USA;  Chicago Cubs starting pitcher Shota Imanaga (18) pitches against the St. Louis Cardinals during the second inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

Jun 26, 2025; St. Louis, Missouri, USA; Chicago Cubs starting pitcher Shota Imanaga (18) pitches against the St. Louis Cardinals during the second inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

MATCHUP Chicago Cubs St. Louis Cardinals
Team Records 59-46 53-52
Where Busch Stadium, St. Louis, Missouri
When Monday, July 27, 2026
Time 07:45 PM EDT
TV MLB.TV
The Chicago Cubs and the St. Louis Cardinals will meet on Monday night in the opening game of a four‑game National League Central series at Busch Stadium in St. Louis, Missouri.

Chicago Cubs Betting Preview

The Chicago Cubs enter Monday’s contest with a 59–46 overall record (2nd in the National League Central) and a 29–24 mark on the road. The Cubs offense has been competitive to this point in the season. Through 105 games played in 2026, Chicago has compiled 541 runs scored (4th in MLB), 170 doubles, a .247 team batting average and 131 home runs which ranks tenth in Major League Baseball.

The Cubs arrive at tomorrow night’s game in good form. More specifically, Chicago has won three of the team’s last five games played this season, including a thrilling 3–2 victory over the Pittsburgh pirates earlier this week.

Chicago will turn to left hander David Peterson in this contest. In four starts made this season, Peterson has compiled a 5-7 win‑loss record, a 5.97 ERA, a 1.56 WHIP and 74 strikeouts, while allowing 101 hits and 38 walks in 89 innings pitched. David Peterson has pitched exceptionally well recently, allowing one or fewer earned runs in two consecutive starts made in 2026. Peterson will look to build on his recent strong performances on the mound in tomorrow’s matchup with the St. Louis Cardinals.

The Chicago Cubs lineup features outfielders Pete Crow-Armstrong and Ian Happ. Pete Crow-Armstrong has tallied a .290 batting average, 23 home runs (11th in MLB), 53 walks, 60 RBIs and a .932 OPS which ranks 16th in Major League Baseball. Ian Happ has compiled 18 home runs, 45 RBIs and 18 doubles.      

St. Louis Cardinals Betting Preview

The St. Louis Cardinals enter Monday night’s matchup with a 53–52 overall record (4th in the National League Central) and a 27–29 mark at home. St. Louis arrives at this contest in poor form. The Cardinals have lost seven of the team’s last nine games, including a 4–2 loss to the Cincinnati Reds two days ago.

St. Louis will start left hander Matthew Liberatore in tomorrow’s game. In 20 starts made in 2026, Liberatore has compiled a 5–7 record, a 5.18 ERA, a 1.52 WHIP and 95 strikeouts, while allowing 112 hits and 38 walks in 99 innings pitched. Liberatore has been inconsistent recently, allowing five or more earned runs in three of his last six starts made this season.

Shifting our focus to the St. Louis offense, the Cardinals lineup features outfielder Jordan Walker and first baseman Alec Burleson. Jordan Walker has compiled a .286 batting average, 22 home runs (14th in MLB), 77 RBIs (2nd in MLB) and an .856 OPS. Alec Burleson has amassed a .289 batting average, 15 home runs, 71 RBIs (6th in MLB) and an .820 OPS.   

Why the Chicago Cubs will win.

• Offensive balance. Pete Crow-Armstrong and Ian Happ continue to anchor the Cubs lineup.

• Ability to win on the road. The Chicago Cubs have amassed a 29-24 record on the road.

Why the St. Louis Cardinals will win.

• Enhanced motivation. The St. Louis Cardinals have lost seven of the team’s last nine games.

• Offensive production. Jordan Walker and Alec Burleson provide a strong core to the St. Louis Cardinals lineup.

Chicago Cubs vs. St. Louis Cardinals Prediction

In my view, this matchup favors the Chicago Cubs. Why? Chicago starting pitcher David Peterson has pitched exceptionally well recently, allowing one or fewer earned runs in two consecutive starts made in 2026. Conversely, St. Louis hurler Matthew Liberatore has been far more inconsistent, allowing five or more earned runs in three of his last six starts made this season. With that said, the Cubs are the clear side to be on in this one. I am backing the Chicago Cubs on the moneyline in this game.

Hans Geevers's Pick: Chicago Cubs ML

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