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Chicago Cubs vs Seattle Mariners Prediction 8/21/2026 Today’s MLB Picks

Jul 22, 2026; Seattle, Washington, USA; Seattle Mariners starting pitcher Emerson Hancock (26) throws against the Cincinnati Reds during the first inning at T-Mobile Park. Mandatory Credit: Joe Nicholson-Imagn Images

Jul 22, 2026; Seattle, Washington, USA; Seattle Mariners starting pitcher Emerson Hancock (26) throws against the Cincinnati Reds during the first inning at T-Mobile Park. Mandatory Credit: Joe Nicholson-Imagn Images

MATCHUP Chicago Cubs Seattle Mariners
Team Records 74-54 60-68
Spread -1.5 161 +1.5 -197
Moneyline -108 -112
Total Over 8 (-105) Under 8 (-115)
Where T-Mobile Park, Seattle, Washington
When Friday, August 21, 2026
Time 10:10 PM EDT
TV MLB.TV
In this article, we will formulate a Cubs vs Mariners Prediction for this MLB matchup on Friday, August 21st in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview


The Seattle Mariners have a 60-68 record this season and are sitting in 3rd place in the AL West. They have a 33-29 home record and are coming off a 4-7 road loss against the Brewers. They will face the Phillies and the Blue Jays next.

The Seattle Mariners have a .230 batting average this season, a .310 OBP, and a .377 slugging percentage. The Mariners’ pitching staff has a 3.97 ERA and a 1.22 WHIP. Randy Arozarena leads the Mariners with a .272 batting average. Cole Young leads the team in RBI with 56, while Julio Rodriguez adds a team-high 19 home runs.

Emerson Hancock (R) is the projected starting pitcher for the Mariners, and he has a 7-7 record, a 3.30 ERA, and a 1.11 WHIP.

Chicago Cubs Preview


The Chicago Cubs have a 74-54 record this season and are sitting in 2nd place in the NL Central. They have a 36-27 road record and are coming off a 0-3 home loss against the White Sox. They will face the Diamondbacks and the Reds next.

The Chicago Cubs have a .248 batting average this season, a .337 OBP, and a .418 slugging percentage. The Cubs’ pitching staff has a 4.14 ERA and a 1.26 WHIP. Pete Crow-Armstrong leads the Cubs with a .279 batting average, while leading the team in RBI with 79 and adding a team-high 31 home runs.

Matthew Boyd (L) is the projected starting pitcher for the Cubs, and he has an 8-2 record, a 4.02 ERA, and a 1.24 WHIP.

The Chicago Cubs @ Seattle Mariners Betting Trends: August 21, 2026


Why the Seattle Mariners will win

Why the Chicago Cubs will win

Total Runs Facts

Seattle Mariners Player Prop Facts

Chicago Cubs Player Prop Facts

Matchup/League Facts

Cubs vs Mariners Prediction


The Diamondbacks are 4-2 in their last 6 meetings against the Reds and are 3-1 in their last 4 meetings in Arizona.

In this Cubs vs Mariners Prediction, both teams are coming at a pickem price. I don’t like the pitching in this matchup, as both starters have been in poor form. Boyd has given up 13 runs in his last three starts and Hancock has given up at least two runs in each of his last five starts. The Mariners’ bullpen has been atrocious lately and both teams are 11-5 to the over in their last 16 games combined. The total is set too low for this game. Take the over 7.5 runs.

Nikos Lagouretos's Pick: Over 7.5

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