Chicago Cubs vs San Francisco Giants Prediction 8/26/2025 Today’s MLB Picks

The Chicago Cubs and the San Francisco Giants meet Tuesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. San Francisco Giants prediction.

Starting Pitching Matchup

The Chicago Cubs will start Matthew Boyd here and Boyd is 12-6 with a 2.61 ERA and 129 strikeouts this season. This will be Boyd’s second career start against the Giants. Justin Verlander will get the nod for the Giants and is 1-10 with a 4.64 ERA and 99 strikeouts this season. In his career, Verlander is 2-0 with a 2.35 ERA and 22 strikeouts against the Cubs.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to build on their win over the Los Angeles Angels in Sunday’s series finale by a final score of 4-3 to improve to 76-55 this season. After this series, the Cubs will head on the road for a series against the Colorado Rockies.

Cubs Win 6 Of Their Last 7 Following Sweep

Ian Happ has 103 hits with 22 doubles, 16 home runs and 56 RBIs. Kyle Tucker has 121 hits including 22 doubles, 4 triples, 21 home runs and 69 RBIs while Seiya Suzuki also has 118 hits with 27 doubles and 27 home runs and 87 RBIs of his own. Pete Crow-Armstrong also has contributed 125 hits, 33 doubles, 4 triples, 28 home runs and 82 RBIs as well this season. Dansby Swanson has added 18 home runs and 58 RBIs, while also having 141 strikeouts and Suzuki has 142 strikeouts so far this season. Crow-Armstrong also has a team-high 30 stolen bases while Nico Hoerner has 23 stolen bases this season. Tucker’s also added 25 stolen bases while Michael Busch has also chipped in 19 doubles, 3 triples, 24 home runs and 74 RBIs this season.

Why the Chicago Cubs will win

• The Giants have lost each of their last eight night games against NL Central opponents following a win.
• The Cubs have won seven of their last eight night games against National League opponents that held a losing record.
• The Giants have failed to cover the run line each of their last seven home games against teams that held a winning record.
• The road team has covered the run line in four of the last five games between the Cubs and Giants.

Chicago Cubs Player Prop Facts

• Kyle Tucker has hit at least one home run in each of the Cubs’ last two night games against opponents that held a losing record.
• Dansby Swanson has recorded a Double in three of the Cubs’ last four games against opponents that held a losing record.
• Matthew Boyd has recorded a win in four of his last five appearances with the Cubs as favorites against NL West opponents.
• Matthew Boyd has recorded five or more strikeouts in eight of his last nine appearances in night games against teams that held a losing record.
• Seiya Suzuki has recorded at least one hit in each of his last 16 appearances in night games against NL West teams that held a losing record.
• Matthew Boyd ranks 5th amongst qualified players for Earned Run Average (2.61) this season.

San Francisco Giants Recap

The San Francisco Giants come into this one looking to add on to their series win over the Milwaukee Brewers thanks to a 4-3 win over the Brew Crew to improve to 63-68 this season. After this series, the Giants will take on the Orioles in an interleague series at home.

Giants Win Back-To-Back Games

Jung Hoo Lee has 122 hits including a team-high 29 doubles along with 10 triples, 7 home runs and 47 RBIs with 10 stolen bases while Heliot Ramos has 130 hits with 22 doubles, 15 home runs and 55 RBIs. Wilmer Flores also 13 home runs and 63 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 80 hits with 16 home runs and 44 RBIs along with 15 doubles and Willy Adames has 108 hits with 18 doubles, 22 home runs and 65 RBIs of his own this season.

Why the San Francisco Giants will win

• The Cubs have lost seven of their last eight games as favorites against National League opponents following a win.
• The Giants have won four of their last five games as underdogs against NL Central opponents.
• The Cubs have failed to cover the run line in each of their last eight games as favorites against National League opponents following a win.
• The Giants have covered the run line in each of their last five games as underdogs against NL Central opponents.

San Francisco Giants Player Prop Facts

• Willy Adames has hit a home run in each of his last two appearances with his team as a home underdog against the Cubs.
• Casey Schmitt has recorded at least one Double in three of his last four home appearances against NL Central opponents that held a winning record.
• Justin Verlander has recorded five or more strikeouts in each of his last six appearances with his team as a home underdog.
• Dominic Smith has recorded at least one hit in each of his last 14 appearances in night games.

Total Runs Facts

• Six of the Cubs’ last seven road games have gone UNDER the total runs line.
• Five of the Giants’ last six games as underdogs against the Cubs have gone OVER the total runs line.

Chicago Cubs vs. San Francisco Giants Prediction

I’m looking at the Cubs here. The Giants just can’t seem to find wins with Verlander on the hill, and I just don’t see it happening here with their offensive struggles against lefties and against one of the more underrated lefties in baseball in Boyd. I think the Cubs keep it going here so I’ll roll with Chicago in this one.