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Chicago Cubs vs San Diego Padres Prediction 9/29/2026 Today’s MLB Picks

Sep 27, 2026; San Diego, California, USA;  San Diego Padres right fielder Fernando Tatis Jr. (23) walks on the field during the fourth inning against the Arizona Diamondbacks at Petco Park.  Mandatory Credit: Denis Poroy-Imagn Images

Sep 27, 2026; San Diego, California, USA; San Diego Padres right fielder Fernando Tatis Jr. (23) walks on the field during the fourth inning against the Arizona Diamondbacks at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

MATCHUP Chicago Cubs San Diego Padres
Team Records 89-73 91-71
Spread +1.5 -206 -1.5 168
Moneyline +105 -126
Total Over 7 (-117) Under 7 (-103)
Where San Diego Stadium
When Tuesday, September 29, 2026
Time 10:00 PM EDT
TV Peacock
The Chicago Cubs and San Diego Padres meet Tuesday in MLB playoff action at Petco Park. Here’s a Chicago Cubs vs. San Diego Padres Prediction. This article will include a Chicago Cubs vs. San Diego Padres Pick.

Chicago Cubs Betting Preview


The Chicago Cubs are 89-73 on the year and just played the Marlins and Red Sox. The Chicago Cubs are batting .251 on the season and have a .339 OBP and a .428 slugging percentage. The Chicago Cubs’ pitching staff has a 4.12 ERA and a 1.26 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 175 hits and 107 RBI, while Alex Bregman and Nico Hoerner have combined for 326 hits and 165 RBI.

Matthew Boyd gets the ball for the Chicago Cubs, and he is 10-5 with a 3.91 ERA and 96 strikeouts this season. Boyd is 2-1 with a 4.43 ERA and 14 strikeouts in his career against the San Diego Padres. Boyd is 0-1 with a 1.66 ERA and 23 strikeouts in his postseason career.

San Diego Padres Betting Preview


The San Diego Padres are 91-71 on the year after playing the Dodgers and Diamondbacks. The San Diego Padres are batting .244 on the season, have a .319 OBP, and have a .398 slugging percentage. The San Diego Padres’ pitching staff has a 3.99 ERA and a 1.29 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 181 hits and 83 RBI, while Jackson Merrill and Ty France have combined for 286 hits and 159 RBI.

Michael King gets the ball for the San Diego Padres, and he is 12-10 with a 3.21 ERA and 159 strikeouts this season. King is 0-0 with a 0.00 ERA and 1 strikeout in his career against the Chicago Cubs. King is 2-0 with a 3.00 ERA and 19 strikeouts in his postseason career.

Why the San Diego Padres will win

Why the Chicago Cubs will win

Total Runs Facts

San Diego Padres Player Prop Facts

Chicago Cubs Player Prop Facts

Matchup/League Facts

Chicago Cubs vs San Diego Padres Prediction


The Padres should be favored at home with King on the mound, but this franchise has a history of coming up small when the lights get bright. An explosive, confident Cubs team could go on the road and spring an upset. Boyd is a veteran pitcher who has been in big spots before, and on the road through 66 innings, he has a 2.86 ERA and a .220 allowed batting average. In his last 35.2 innings, Boyd has allowed 29 hits and 13 earned runs. I’ve seen the Padres in October before, and it doesn’t end well typically. Give me the Cubs and the plus money.

Randy Chambers's Pick: Chicago Cubs

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