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Chicago Cubs vs Milwaukee Brewers Prediction 10/6/2025 Today’s MLB Picks

Sep 25, 2025; Chicago, Illinois, USA; Chicago Cubs pitcher Shota Imanaga (18) throws the ball against the New York Mets during the first inning at Wrigley Field. Mandatory Credit: David Banks-Imagn Images

Sep 25, 2025; Chicago, Illinois, USA; Chicago Cubs pitcher Shota Imanaga (18) throws the ball against the New York Mets during the first inning at Wrigley Field. Mandatory Credit: David Banks-Imagn Images

MATCHUP Chicago Cubs Milwaukee Brewers
Team Records 92-70 97-65
Where American Family Field, Milwaukee, Wisconsin
When Monday, October 6, 2025
Time 09:08 PM EDT
TV TBS

In this article, we will formulate a Cubs vs Brewers Prediction for this MLB game on Monday, October 6th at the American Family Field in Game 2 of this NLDS series, with the Brewers having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers finished the regular season with a 97-65 record and were placed first in the NL Central. The Brewers have a 53-29 home record and are 78-80 in over/under. They are coming off a 9-3 home victory over the Cubs in Game 1, and have back-to-back wins. Under is 6-3 in their last 9 games.  

The Brewers have a .258 batting average this season, .332 OBP and .403 slugging percentage. Milwaukee’s pitching staff has a 3.58 ERA and 1.23 WHIP. Jackson Chourio leads the Brewers with 3 hits in the playoffs, adding a team-high 3 RBI. Blake Perkins is the team’s best hitter, with a .500 batting average.

Reliever Aaron Ashby (L) is the projected starting pitcher for the Brewers, and he has a 5-2 record, 2.16 ERA and 1.17 WHIP.

Chicago Cubs Preview

The Chicago Cubs finished the regular season with a 92-70 record and were placed second in the NL Central. The Cubs have a 42-40 road record and are 75-78 in over/under. They are coming off a 3-9 road defeat by the Brewers, and have lost two of their last three games. Under is 4-1 in their last 5 games.

The Cubs have a .249 batting average this season, .320 OBP and .430 Slugging percentage. Chicago’s pitching staff has a 3.79 ERA and 1.18 WHIP. Nico Hoerner leads the team with 5 hits, adding a team-high 2 RBI. Michael Busch is the team’s best hitter, adding a team-high two home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 0-0 record, 4.50 ERA and 1.25 WHIP in the postseason.

The Chicago Cubs @ Milwaukee Brewers Betting Trends: October 6, 2025

Why the Milwaukee Brewers will win

Why the Chicago Cubs will win

Total Runs Facts

Milwaukee Brewers Player Prop Facts

Chicago Cubs Player Prop Facts

Matchup/League Facts

Cubs vs Brewers Prediction

The Cubs are 3-2 in their last 5 meetings against the Brewers, but the Brewers are 3-1 in their last 4 meetings in Milwaukee. Over is 4-0 in their last 4 meetings in Milwaukee.

In this Cubs vs Brewers Prediction, the Brewers are coming as -125 home favorites. The Brewers blew out the Cubs in Game 1 with a 9-3 score, but they are going for a bullpen game today. They have a slightly better bullen ERA than the Cubs, who are putting Imanaga on the mound, who has been atrocious lately, with a 6.51 ERA across his last five starts. He has at least 3 earned runs in six of his last seven starts, and I don’t trust him on the road in this spot. The Brewers have a better offense, and are the best team against lefties in baseball, while the Cubs are weaker against southpaws. Take the Milwaukee Brewers to get the job done at home in this one.

Nikos Lagouretos's Pick: Milwaukee Brewers -125

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