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Chicago Cubs vs Los Angeles Angels Prediction 8/22/2025 Today’s MLB Picks

Apr 23, 2025; Chicago, Illinois, USA;  Chicago Cubs shortstop Dansby Swanson (7) hits a two RBI single against the Los Angeles Dodgers during the fifth inning at Wrigley Field. Mandatory Credit: Matt Marton-Imagn Images

Apr 23, 2025; Chicago, Illinois, USA; Chicago Cubs shortstop Dansby Swanson (7) hits a two RBI single against the Los Angeles Dodgers during the fifth inning at Wrigley Field. Mandatory Credit: Matt Marton-Imagn Images

MATCHUP Chicago Cubs Los Angeles Angels
Team Records 74-55 61-67
Where Angel Stadium, Anaheim, California
When Friday, August 22, 2025
Time 09:38 PM EDT
TV FanDuel SN West
In this article, we will formulate a Cubs vs Angels Prediction for this MLB game on Friday, August 22nd at the Angel Stadium in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Angels Preview

The Los Angeles Angels have a 61-66 record this season and are sitting on the 4th place of the AL West. The Angels have a 34-32 home record and 71-53 in over/under They are coming off a 2-1 home victory over the Reds, which ended their previous two-game losing streak. Over is 9-3 in their last 12 games and are playing the Astros and the Rangers next.

The Angels have a .233 batting average this season, .306 OBP and .407 Slugging percentage. LA’s pitching staff has a 4.67 ERA and 1.43 WHIP. Nolan Schanuel leads the Angels with 123 hits, and he is the team’s best hitter with a .269 batting average. Taylor Ward leads the team with 92 RBI, adding a team-high 29 home runs.

Tyler Anderson (L) is the projected starting pitcher for the Angels, and he has a 2-8 record, 4.77 ERA and 1.42 WHIP.

Chicago Cubs Preview

The Chicago Cubs have a 73-55 record this season and are sitting on the second place of the NL Central. The Cubs have a 32-30 road record and are 58-59 in over/under. They are coming off a 1-4 home victory over the Brewers, which ended their three-game winning streak. Under is 9-2-1 in their last 12 games, and are playing the Rockies and the Giants next.

The Cubs have a .249 batting average this season, .319 OBP and .427 Slugging percentage. Chicago’s pitching staff has a 3.81 ERA and 1.21 WHIP. Nico Hoerner leads the Cubs with 134 hits, and he is the team’s best hitter with a .289 batting average. Seiya Suzuki leads the team in RBI, with 86, adding a team-high 27 home runs.

The Cubs have not yet announced a starting pitcher for this game.

Why the Los Angeles Angels will win


Why the Chicago Cubs will win

Total Runs Facts

Matchup/League Facts


Cubs vs Angels Prediction

The Angels are 4-2 in their last 6 meetings against the Cubs, having won their last three meetings in Los Angeles. Under is 7-2-1 in their last 10 meetings.

In this Cubs vs Angels Prediction, the Cubs are coming as -150 road favorites. The Cubs are big road favorites, but given the uncertainty behind their starting pitcher, I’m not rushing to back them up. Andreson has been very good at home for the Angels, with a 3.82 home ERA, and the Angels have more home wins than the Cubs have on the road. On top of that, the Cubs are much weaker against left-handed pitching, so I like the chances of the Angels as home dogs in this one,

Nikos Lagouretos's Pick: Los Angeles Angels +130

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