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Chicago Cubs vs Cleveland Guardians Prediction 4/5/2026 Today’s MLB Picks

Guardians right fielder Chase DeLauter makes contact during the home opener against the Chicago Cubs, April 4, 2026, in Cleveland.

Guardians right fielder Chase DeLauter makes contact during the home opener against the Chicago Cubs, April 4, 2026, in Cleveland.

MATCHUP Chicago Cubs Cleveland Guardians
Team Records 4-5 6-4
Where Progressive Field, Cleveland, Ohio
When Sunday, April 5, 2026
Time 01:10 PM EDT
TV MLB.TV

The Chicago Cubs and Cleveland Guardians meet Sunday in an MLB doubleheader at Progressive Field. Here’s a Chicago Cubs vs. Cleveland Guardians Prediction. This article will include a Chicago Cubs vs. Cleveland Guardians Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 3-4 on the year and play the Rays and Pirates next. The Chicago Cubs are batting .222 on the season and have a .315 OBP, and a .342 slugging percentage. The Chicago Cubs pitching staff has a 3.63 ERA and a 1.16 WHIP. Nico Hoerner leads the Chicago Cubs with 7 hits and 3 RBI, while Pete Crow-Armstrong and Alex Bregman have combined for 13 hits and 6 RBI.

Edward Cabrera and Shota Imanaga get the ball for the Cubs.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 5-3 on the year and play the Royals and Braves next. The Cleveland Guardians are batting. 203 on the season, have a .287 OBP, and have a .348 slugging percentage. The Cleveland Guardians pitching staff has a 3.60 ERA and a 1.21 WHIP. Chase DeLauter leads the Cleveland Guardians with 9 hits and 8 RBI while Steven Kwan and Jose Ramirez have combined for 13 hits and 7 RBI.

Parker Messick and Slade Cecconi get the ball for the Cleveland Guardians.

Why the Cleveland Guardians will win

Why the Chicago Cubs will win

Total Runs Facts

Cleveland Guardians Player Prop Facts

Chicago Cubs Player Prop Facts

Matchup/League Facts

Chicago Cubs vs Cleveland Guardians Prediction

Game 1 Prediction: Cabrera is a talented pitcher who has a chance to shine now that he’s out of Miami. He looked great through six innings against the Angels and should be able to build on that showing. Cecconi has been hittable throughout his career and he was rocked by the Mariners in his season debut. The Cubs have a major edge on the mound. Give me the Cubs in game 1.

Game 2 Prediction: Messick was sharp in his season debut but he’s still a young pitcher with just eight career starts. I like larger sample sizes in my pitchers. Imanaga has been solid through his first two seasons, so I’m not concerned about his season debut. Imanaga has earned the benefit of the doubt. It’s not easy to win both games in a doubleheader, but I like the pitching edge with the Cubs. Give me the road team.

Randy Chambers's Pick: Game 1: Chicago Cubs / Game 2: Chicago Cubs

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