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Chicago Cubs vs Cincinnati Reds Prediction 9/18/2026 Today’s MLB Picks

Sep 13, 2026; Milwaukee, Wisconsin, USA;  Cincinnati Reds starting pitcher Chase Burns (26) throws a pitch in the first inning against the Milwaukee Brewers at American Family Field.  Mandatory Credit: Benny Sieu-Imagn Images

Sep 13, 2026; Milwaukee, Wisconsin, USA; Cincinnati Reds starting pitcher Chase Burns (26) throws a pitch in the first inning against the Milwaukee Brewers at American Family Field. Mandatory Credit: Benny Sieu-Imagn Images

MATCHUP Chicago Cubs Cincinnati Reds
Team Records 85-68 71-82
Spread -1.5 123 +1.5 -149
Moneyline -131 +109
Total Over 8.5 (-121) Under 8.5 (101)
Where Great American Ball Park, Cincinnati, Ohio
When Friday, September 18, 2026
Time 06:40 PM EDT
TV MLB.TV
In this article, we will formulate a Cubs vs Reds Prediction for this MLB matchup on Friday, September 18th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Cincinnati Reds Preview


The Cincinnati Reds have a 71-82 record this season and are sitting in the 5th place of the NL Central. They have a 37-41 home record and are coming off a 2-8 home loss against the Dodgers. They will face the Braves and the Blue Jays next.

The Cincinnati Reds have a .230 batting average this season, .307 OBP and .396 Slugging percentage. Cincinnati’s pitching staff has a 4.87 ERA and 1.45 WHIP. Elly De La Cruz is the team’s best hitter with a .284 batting average. Sal Stewart leads the team in RBI with 109, adding a team-high 32 home runs.

Chase Burns (R) is the projected starting pitcher for the Reds, and he has a 15-3 record, 2.80 ERA and 1.15 WHIP.

Chicago Cubs Preview


The Chicago Cubs have a 85-68 record this season and are sitting in the 2nd place of the NL Central. They have a 40-35 away record and are coming off an 8-4 home win against the Braves. They will face the Marlins and the Red Sox next.

The Chicago Cubs have a .252 batting average this season, .340 OBP and .431 Slugging percentage. Chicago’s pitching staff has a 4.19 ERA and 1.27 WHIP. Pete Crow-Armstrong is the team’s best hitter with a .282 batting average, leading the team in RBI with 105, adding a team-high 44 home runs.

Clay Holmes (R) is the projected starting pitcher for the Cubs, and he has a 6-7 record, 2.85 ERA and 1.15 WHIP.

The Chicago Cubs @ Cincinnati Reds Betting Trends: September 18, 2026


Why the Cincinnati Reds will win

Why the Chicago Cubs will win

Total Runs Facts

Cincinnati Reds Player Prop Facts

Chicago Cubs Player Prop Facts

Matchup/League Facts

Cubs vs Reds Prediction


The Cubs are 7-3 in their last 10 meetings against the Reds and have won their last two visits in Cincinnati.  

In this Cubs vs Reds Prediction, the Cubs are coming as -125 road favorites. I like the Reds in this one with Chase Burns on the mound, who has been elite this season and one of the best home pitchers in baseball, with an 8-1 record and 2.09 ERA at home. The Reds also have a better bullpen ERA than the Cubs in their last 5 games and the Cubs have lost their last four games on the road. Take the Reds in this one at home for plus money.

Nikos Lagouretos's Pick: Cincinnati Reds ML

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