Chicago (60-42) vs Chicago (37-66)
July 25, 2025 at 07:40 PM EDT
The Line: Betting Odds: Chicago +1.5 — Over/Under: +8.5
The Chicago Cubs and Chicago White Sox meet Friday in MLB action at Rate Field. Here’s a Chicago Cubs vs Chicago White Sox Prediction. This article will include a Chicago Cubs vs Chicago White Sox Pick.
Chicago Cubs Betting Preview
The Chicago Cubs are 60-42 on the year and play the Brewers, Orioles, and Reds next. The Chicago Cubs are batting .256 on the season, have a .324 OBP, and a .446 slugging percentage. The Chicago Cubs pitching staff has a 3.86 ERA and a 1.22 WHIP. Nico Hoerner leads the Chicago Cubs with 107 hits and 41 RBI, while Pete Crow-Armstrong and Kyle Tucker have combined for 208 hits and 131 RBI.
Shota Imanaga gets the ball for the Chicago Cubs, and he is 7-3 with a 2.40 ERA and 53 strikeouts this season. This will be Imanaga’s second career game against the Chicago White Sox.
Chicago White Sox Betting Preview
The Chicago White Sox are 37-66 on the year and play the Phillies, Angels, and Mariners next. The Chicago White Sox are batting .224 on the season, have a .298 OBP, and a .354 slugging percentage. The Chicago White Sox pitching staff has a 4.08 ERA and a 1.38 WHIP. Lenyn Sosa leads the Chicago White Sox with 81 hits and 34 RBI while Miguel Vargas and Chase Meidroth have combined for 153 hits and 54 RBI.
Adrian Houser gets the ball for the Chicago White Sox, and he is 5-2 with a 1.89 ERA and 44 strikeouts this season. Houser is 3-2 with a 3.98 ERA and 49 strikeouts in his career against the Chicago Cubs.
Why the Chicago White Sox will win
- The White Sox have won five of their last six games as underdogs.
- The Cubs have lost three of their last four games as road favorites following a home loss.
- The White Sox have covered the run line in each of their last seven games as underdogs.
- The Cubs have failed to cover the run line in five of their last six night games against teams that held a losing record.
- The White Sox have led after 5 innings in three of their last four games as underdogs against National League opponents.
- The Cubs have trailed after 3 innings in three of their last four road games against AL Central opponents.
Why the Chicago Cubs will win
- The White Sox have lost 21 of their last 22 night games against National League opponents that held a winning record.
- The Cubs have won each of their last eight games as favorites against the White Sox.
- The Cubs have covered the run line in eight of their last nine games as favorites against AL Central opponents following a loss.
- The White Sox have failed to cover the run line in six of their last seven night games at Rate Field following a road win.
- The Cubs have led after 3 innings in five of their last six games against American League opponents.
- The White Sox have trailed after 5 innings in three of their last four games against National League opponents that held a winning record.
Chicago White Sox Player Prop Facts
- Miguel Vargas has hit a home run in two of his last three appearances in night games against NL Central teams that held a winning record.
- Adrian Houser has recorded four or more strikeouts in four of his last five appearances against opponents that held a winning record.
- Andrew Benintendi has recorded at least one hit in each of his last nine appearances against NL Central opponents that held a winning record.
- Adrian Houser has recorded a win in each of his five previous appearances at Rate Field against opponents that held a winning record.
- Michael A. Taylor has recorded a Double in four of his last five appearances against NL opponents.
Chicago Cubs Player Prop Facts
- Ian Happ has hit a home run in two of the Cubs’ last three games against the White Sox at Rate Field.
- Dansby Swanson has recorded at least one hit in each of the Cubs’ last 12 games against AL opponents that held a losing record.
- Shota Imanaga has recorded a win in four of his last five appearances.
- Pete Crow-Armstrong ranks 6th in the league in Home Runs (27) this season.
Chicago Cubs vs Chicago White Sox Prediction
The White Sox have caught fire in the second half of the season, but I don’t expect it to last long. The White Sox are easily one of the worst teams in the league, and a team I’ve faded a ton over the last few years. Imanaga has allowed 16 hits and six runs in his last 25.1 innings, and he has a 2.40 ERA and 0.92 WHIP on the season. In 40.2 road innings, Imanaga has a 1.33 ERA and .175 allowed batting average. Houser has been great and the White Sox have won five straight games he’s pitched. Still, I don’t want anything to do with the White Sox. Give me the Cubs.