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Chicago Cubs vs Chicago White Sox Prediction 07/25/2025 Picks

Jul 13, 2025; Bronx, New York, USA; Chicago Cubs pitcher Shota Imanaga (18) delivers a pitch against the New York Yankees during the second inning at Yankee Stadium. Mandatory Credit: Gregory Fisher-Imagn Images

Jul 13, 2025; Bronx, New York, USA; Chicago Cubs pitcher Shota Imanaga (18) delivers a pitch against the New York Yankees during the second inning at Yankee Stadium. Mandatory Credit: Gregory Fisher-Imagn Images

MATCHUP Chicago Cubs Chicago White Sox
Team Records 60-42 37-66
Where Rate Field, Chicago, Illinois
When Friday, July 25, 2025
Time 07:40 PM EDT
TV MLB.TV

The Chicago Cubs and Chicago White Sox meet Friday in MLB action at Rate Field. Here’s a Chicago Cubs vs Chicago White Sox Prediction. This article will include a Chicago Cubs vs Chicago White Sox Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 60-42 on the year and play the Brewers, Orioles, and Reds next. The Chicago Cubs are batting .256 on the season, have a .324 OBP, and a .446 slugging percentage. The Chicago Cubs pitching staff has a 3.86 ERA and a 1.22 WHIP. Nico Hoerner leads the Chicago Cubs with 107 hits and 41 RBI, while Pete Crow-Armstrong and Kyle Tucker have combined for 208 hits and 131 RBI. 

Shota Imanaga gets the ball for the Chicago Cubs, and he is 7-3 with a 2.40 ERA and 53 strikeouts this season. This will be Imanaga’s second career game against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 37-66 on the year and play the Phillies, Angels, and Mariners next. The Chicago White Sox are batting .224 on the season, have a .298 OBP, and a .354 slugging percentage. The Chicago White Sox pitching staff has a 4.08 ERA and a 1.38 WHIP. Lenyn Sosa leads the Chicago White Sox with 81 hits and 34 RBI while Miguel Vargas and Chase Meidroth have combined for 153 hits and 54 RBI.

Adrian Houser gets the ball for the Chicago White Sox, and he is 5-2 with a 1.89 ERA and 44 strikeouts this season. Houser is 3-2 with a 3.98 ERA and 49 strikeouts in his career against the Chicago Cubs.

Why the Chicago White Sox will win

Why the Chicago Cubs will win

Chicago White Sox Player Prop Facts

Chicago Cubs Player Prop Facts

Chicago Cubs vs Chicago White Sox Prediction

The White Sox have caught fire in the second half of the season, but I don’t expect it to last long. The White Sox are easily one of the worst teams in the league, and a team I’ve faded a ton over the last few years. Imanaga has allowed 16 hits and six runs in his last 25.1 innings, and he has a 2.40 ERA and 0.92 WHIP on the season. In 40.2 road innings, Imanaga has a 1.33 ERA and .175 allowed batting average. Houser has been great and the White Sox have won five straight games he’s pitched. Still, I don’t want anything to do with the White Sox. Give me the Cubs.

Randy Chambers's Pick: Chicago Cubs

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