Chicago Cubs vs Baltimore Orioles Prediction 08/01/2025 Picks

The Baltimore Orioles and the Chicago Cubs meet Friday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Chicago Cubs prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Trevor Rogers for the start here and is 4-1 with a 1.49 ERA and 40 strikeouts this season. This will be Rogers’ first career start against the Cubs. The Cubs will start Cade Horton here and Horton is 4-3 with a 3.67 ERA and 50 strikeouts this season. This will be Horton’s first career start against the Orioles.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from a 9-8 loss at the hands of the Blue Jays in Wednesday’s series finale to sit at 50-59 on the year. After this series, the Orioles will head on the road for another interleague series against the Phillies.

Orioles Have Five-Game Win Streak Snapped

Adley Rutschman has 59 hits with 12 doubles, 8 homers and 25 RBIs. Jackson Holliday has 105 hits with 15 doubles, 2 triples, 14 homers and 43 RBIs. Ryan Mountcastle has 46 hits with 13 doubles, 2 homers and 15 RBIs and Gunnar Henderson has a team-high 101 strikeouts as well this season. Heston Kjerstad’s added 4 homers and 19 RBIs while Jordan Westburg has 12 home runs and 26 RBIs this season.

Why the Baltimore Orioles will win

• The Orioles have won five of their last six games as underdogs against National League opponents.
• The Cubs have lost three of their last four games as favorites against AL East opponents following a road win.
• The Orioles have covered the run line in each of their last six games as underdogs against National League opponents.
• The Cubs have failed to cover the run line in seven of their last eight games against AL East opponents that held a losing record.

Baltimore Orioles Player Prop Facts

• Trevor Rogers has recorded five or more strikeouts in each of his last four appearances against NL opponents.
• Colton Cowser has recorded at least one hit in each of his last 13 appearances against NL opponents that held a winning record.
• Trevor Rogers has recorded a win in three of his last four appearances.
• Cedric Mullins has recorded at least one Double in each of his last three appearances against opponents that held a winning record.
• Gary Sanchez has hit a home run in four of his last five road appearances against NL Central opponents that held a winning record.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their 10-3 win over the Milwaukee Brewers last time out to sit at 63-45 on the year. After this series, the Cubs will square off against the Cincinnati Reds at home.

Cubs Avoid Sweep Vs. Rival Brewers

Ian Happ has 88 hits with 17 doubles, 15 home runs and 51 RBIs. Kyle Tucker has 108 hits including 21 doubles, 4 triples, 18 home runs and 61 RBIs while Seiya Suzuki also has 103 hits with 25 doubles and 26 home runs and 81 RBIs of his own. Pete Crow-Armstrong also has contributed 113 hits, 30 doubles, 4 triples, 27 home runs and 78 RBIs as well this season. Dansby Swanson has added 16 home runs and 51 RBIs, while also having 123 strikeouts and Suzuki has 124 strikeouts so far this season. Crow-Armstrong also has a team-high 29 stolen bases while Nico Hoerner has 19 stolen bases this season. Tucker’s also added 23 stolen bases while Michael Busch has also chipped in 15 doubles, 3 triples, 21 home runs and 61 RBIs this season.

Why the Chicago Cubs will win

• The Cubs have won seven of their last eight day games against AL East opponents that held a losing record.
• The Orioles have lost each of their last five road games following a home loss.
• The Cubs have covered the run line in eight of their last nine day games at Wrigley Field following a road win.
• The Orioles have failed to cover the run line in four of their last five road games following a home loss.

Chicago Cubs Player Prop Facts

• Ian Happ has hit a home run in three of the Cubs’ last four home games against AL East opponents that held a losing record.
• Justin Turner has recorded at least one hit in each of his last 10 home appearances against the Orioles.
• Nico Hoerner has recorded a Double in three of the Cubs’ last four home games against AL East opponents that held a losing record.
• Pete Crow-Armstrong ranks T5th in the league in Steals (29) this season.

Total Runs Facts

• Eight of the Cubs’ last nine day games against AL East opponents have gone UNDER the total runs line.
• Four of the Orioles’ last five day games against National League opponents have gone UNDER the total runs line.

Baltimore Orioles vs. Chicago Cubs Prediction

I’m on the Orioles here. I just think Trevor Rogers is the far better starting option in this game over Cade Horton and the Cubs have not been as strong against lefties as they were early on in the year. The Orioles made some moves and sold some key pieces, but I still think they have enough here to get to Horton and to get the win in this one.