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Chicago Cubs vs Baltimore Orioles Prediction 08/01/2025 Picks

Jul 28, 2025; Baltimore, Maryland, USA; Baltimore Orioles shortstop Gunnar Henderson (2) slides into third base safely during the sixth inning against the Toronto Blue Jays at Oriole Park at Camden Yards. Mandatory Credit: Daniel Kucin Jr.-Imagn Images

Jul 28, 2025; Baltimore, Maryland, USA; Baltimore Orioles shortstop Gunnar Henderson (2) slides into third base safely during the sixth inning against the Toronto Blue Jays at Oriole Park at Camden Yards. Mandatory Credit: Daniel Kucin Jr.-Imagn Images

MATCHUP Baltimore Orioles Chicago Cubs
Team Records 50-59 63-45
Where Wrigley Field, Chicago, Illinois
When Friday, August 1, 2025
Time 02:20 PM EDT
TV MLB.TV

The Baltimore Orioles and the Chicago Cubs meet Friday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Chicago Cubs prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Trevor Rogers for the start here and is 4-1 with a 1.49 ERA and 40 strikeouts this season. This will be Rogers’ first career start against the Cubs. The Cubs will start Cade Horton here and Horton is 4-3 with a 3.67 ERA and 50 strikeouts this season. This will be Horton’s first career start against the Orioles.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to rebound from a 9-8 loss at the hands of the Blue Jays in Wednesday’s series finale to sit at 50-59 on the year. After this series, the Orioles will head on the road for another interleague series against the Phillies.

Orioles Have Five-Game Win Streak Snapped

Adley Rutschman has 59 hits with 12 doubles, 8 homers and 25 RBIs. Jackson Holliday has 105 hits with 15 doubles, 2 triples, 14 homers and 43 RBIs. Ryan Mountcastle has 46 hits with 13 doubles, 2 homers and 15 RBIs and Gunnar Henderson has a team-high 101 strikeouts as well this season. Heston Kjerstad’s added 4 homers and 19 RBIs while Jordan Westburg has 12 home runs and 26 RBIs this season.

Why the Baltimore Orioles will win

Baltimore Orioles Player Prop Facts

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their 10-3 win over the Milwaukee Brewers last time out to sit at 63-45 on the year. After this series, the Cubs will square off against the Cincinnati Reds at home.

Cubs Avoid Sweep Vs. Rival Brewers

Ian Happ has 88 hits with 17 doubles, 15 home runs and 51 RBIs. Kyle Tucker has 108 hits including 21 doubles, 4 triples, 18 home runs and 61 RBIs while Seiya Suzuki also has 103 hits with 25 doubles and 26 home runs and 81 RBIs of his own. Pete Crow-Armstrong also has contributed 113 hits, 30 doubles, 4 triples, 27 home runs and 78 RBIs as well this season. Dansby Swanson has added 16 home runs and 51 RBIs, while also having 123 strikeouts and Suzuki has 124 strikeouts so far this season. Crow-Armstrong also has a team-high 29 stolen bases while Nico Hoerner has 19 stolen bases this season. Tucker’s also added 23 stolen bases while Michael Busch has also chipped in 15 doubles, 3 triples, 21 home runs and 61 RBIs this season.

Why the Chicago Cubs will win

Chicago Cubs Player Prop Facts

Total Runs Facts

Baltimore Orioles vs. Chicago Cubs Prediction

I’m on the Orioles here. I just think Trevor Rogers is the far better starting option in this game over Cade Horton and the Cubs have not been as strong against lefties as they were early on in the year. The Orioles made some moves and sold some key pieces, but I still think they have enough here to get to Horton and to get the win in this one.

Chris Ruffolo's Pick: Baltimore +120

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