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Chicago Cubs vs Arizona Diamondbacks Prediction 8/25/2026 Today’s MLB Picks

Aug 19, 2026; Boston, Massachusetts, USA; Arizona Diamondbacks starting pitcher Brandon Pfaadt (32) pitches against the Boston Red Sox during the first inning at Fenway Park. Mandatory Credit: Brian Fluharty-Imagn Images

Aug 19, 2026; Boston, Massachusetts, USA; Arizona Diamondbacks starting pitcher Brandon Pfaadt (32) pitches against the Boston Red Sox during the first inning at Fenway Park. Mandatory Credit: Brian Fluharty-Imagn Images

MATCHUP Chicago Cubs Arizona Diamondbacks
Team Records 76-56 69-63
Spread -1.5 149 +1.5 -181
Moneyline -112 -108
Total Over 8.5 (-102) Under 8.5 (-118)
Where Chase Field, Phoenix, Arizona
When Tuesday, August 25, 2026
Time 09:40 PM EDT
TV MLB.TV
In this article, we will formulate a Cubs vs Diamondbacks Prediction for this MLB matchup on Tuesday, August 25th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview


The Arizona Diamondbacks have a 69-63 record this season and sit in 3rd place in the NL West. They have a 38-29 home record and are coming off a 0-7 home loss against the Cubs. They will face the Giants and the Phillies next.

The Arizona Diamondbacks have a .245 batting average this season, .318 OBP, and .401 Slugging percentage. Arizona’s pitching staff has a 4.19 ERA and 1.29 WHIP. Gabriel Moreno is the Diamondbacks’ best hitter with a .303 batting average. Ketel Marte leads the team in RBI with 67, while Nolan Arenado adds a team-high 21 home runs.

Brandon Pfaadt (R) is the projected starting pitcher for the Diamondbacks, holding a 7-1 record, 3.39 ERA, and 1.14 WHIP.

Chicago Cubs Preview


The Chicago Cubs have a 76-56 record this season and sit in 2nd place in the NL Central. They have a 38-29 road record and are coming off a 7-0 road win against the Diamondbacks. They will face the Reds and the Brewers next.

The Chicago Cubs have a .250 batting average this season, .339 OBP, and .423 Slugging percentage. Chicago’s pitching staff has a 4.12 ERA and 1.26 WHIP. Pete Crow-Armstrong is the Cubs’ best hitter with a .278 batting average, while leading the team in RBI with 83, also adding a team-high 33 home runs.

Clay Holmes (R) is the projected starting pitcher for the Cubs, holding a 5-6 record, 2.49 ERA, and 1.11 WHIP.

The Chicago Cubs @ Arizona Diamondbacks Betting Trends: August 25, 2026


Why the Arizona Diamondbacks will win

Why the Chicago Cubs will win

Total Runs Facts

Arizona Diamondbacks Player Prop Facts

Chicago Cubs Player Prop Facts

Matchup/League Facts

Cubs vs Diamondbacks Prediction


The Cubs are 6-1 in their last 7 meetings against the Diamondbacks and have won two of their last three visits in Arizona.

In this Cubs vs Diamondbacks Prediction, both teams are coming at a pickem price. I like the Cubs in this one, as both starting pitchers have been fairly equal, but Holmes has been better on the road with a 2.91 ERA, while Pfaadt has been weaker at home with a 3.56 ERA. The Cubs have better numbers all across the board lately, with a better overall batting average, better batting average vs righties and a better bullpen ERA, so I expect them to get the job on the road in this one.

Nikos Lagouretos's Pick: Chicago Cubs ML

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