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Cardinals vs Rays Prediction 8/22/2025 Today’s MLB Picks

Aug 18, 2025; Miami, Florida, USA; St. Louis Cardinals left fielder Alec Burleson (41) hits an RBI single against the Miami Marlins during the fifth inning at loanDepot Park. Mandatory Credit: Sam Navarro-Imagn Images

Aug 18, 2025; Miami, Florida, USA; St. Louis Cardinals left fielder Alec Burleson (41) hits an RBI single against the Miami Marlins during the fifth inning at loanDepot Park. Mandatory Credit: Sam Navarro-Imagn Images

MATCHUP St. Louis Cardinals Tampa Bay Rays
Team Records 64-65 61-67
Where George M. Steinbrenner Field, Tampa, Florida
When Friday, August 22, 2025
Time 07:35 PM EDT
TV FanDuel SN MW

In this article we will formulate a Cardinals vs Rays prediction for this MLB game on Friday, August 22nd at George M. Steinbrenner Field in Tampa, Florida. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 64-65 this year after they won game one in this series by a score of 7-4 on Thursday night. St. Louis trailed 1-0 in the first inning, but they scored seven of the next nine runs to get the comeback win. The Cardinals recorded 10 hits in the game and they were led by Burleson, who went 2-5 with two RBIs in the win. St. Louis started Gray, who allowed six hits and three earned runs over 5.0 innings for the win, while Romero got the save. 

Prior to this series, the Cardinals won two out of three against the Marlins, but lost all three against the Yankees before that. St. Louis has won three of their last four games and they are currently fourth in the NL Central standings. The St. Louis pitching staff has a 4.25 ERA with a 1.30 WHIP and a .257 opponent batting average, while their offense has scored 565 runs with a .250 batting average and a .318 on base percentage this season. Wilson Contreras has led St. Louis with 18 home runs, 68 RBIs, and four stolen bases, while Alec Burleson has added 15 home runs and 59 RBIs this year. The projected starting pitcher for St. Louis is Miles Mikolas, who is 6-9 with a 4.99 ERA and a 1.30 WHIP over 122.2 innings pitched this year. 

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 61-67 this season after they dropped game one on Thursday night. Tampa Bay cut the deficit to 5-3 in the third inning, but only managed one more run in the defeat. The Rays recorded 10 hits and they committed two errors in the game, while they were led by Diaz, who went 2-3 with one home run and two RBIs in the loss. Tampa Bay started Boyle, who allowed nine hits and five earned runs over 4.0 innings for the loss, while Baker allowed one earned run in relief. 

Prior to this series, the Rays lost both games against the Yankees, but did win two out of three against the Giants before that. Tampa Bay has lost four games in a row and they are currently fourth in the AL East standings. The Tampa Bay pitching staff has a 4.01 ERA with a 1.22 WHIP and a .239 opponent batting average, while the offense has scored 567 runs with a .250 batting average and a .313 on base percentage this season. Junior Caminero has led Tampa Bay with 35 home runs and 86 RBIs, while Brandon Lowe has added 24 home runs and 62 RBIs for the Rays this year. The projected starting pitcher for Tampa Bay is Adrian Houser, who is 6-4 with a 2.67 ERA and a 1.29 WHIP over 84.1 innings pitched this season. 

Why the Cardinals will beat the Rays 

Total Runs Facts

Tampa Bay Rays Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

Cardinals vs Rays Prediction 

St. Louis was able to get the nice win to open this series on Thursday night and they have scored at least seven runs in three of their last four games. The Cardinals are 29-35 on the road this season, while the Rays are 32-33 at home. Tampa Bay has allowed 33 runs in their last four games and they are starting Houser, who has allowed 0, 4, and 5 earned runs in his three starts with the team. The Cardinals are going with Mikolas, who has allowed three earned runs or fewer in four of his last five. Take St. Louis to get another win here. 

David Racey's Pick: Cardinals ML

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