Cardinals vs Nationals Prediction 5/10/25 MLB Picks

In this article we will formulate a Cardinals vs Nationals prediction for this MLB game on Saturday, May 10th at Nationals Park in Washington, DC. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 20-19 this year after they won game one by a score of 10-0 in their last game. St. Louis scored two runs in the first inning and never looked back in the easy win. The Cardinals recorded 11 hits in the game and they were led by Contreras, who went 2-4 with three RBIs in the win. St. Louis started Fedde, who allowed six hits and zero earned runs over 9.0 innings for the complete game shutout. 

Prior to this series, the Cardinals won all three against the Pirates and two out of three against the Mets. St. Louis has won six games in a row and they are currently second in the NL Central standings. The St. Louis pitching staff has a 3.97 ERA with a 1.25 WHIP and a .239 opponent batting average, while their offense has scored 184 runs with a .262 batting average and a .337 on base percentage this season. Wilson Contreras has led St. Louis with five home runs, 22 RBIs, and two stolen bases, while Lars Nootbaar has added five home runs and 19 RBIs this year. The projected starting pitcher for St. Louis is Andre Pallante, who is 2-2 with a 4.75 ERA and a 1.53 WHIP over 36.0 innings pitched this year. 

Washington Nationals Betting Preview

The Washington Nationals are 17-22 this season after they were blown out in game one of this series. Washington fell behind early in the game and they fell apart in the later innings for the 10 run loss. The Nationals recorded six hits and they committed one error in the game, while they were led by Abrams, who had three hits in the loss. Washington started Parker, who allowed seven hits and four earned runs over 4.0 innings in the loss, while Sims allowed three earned runs in just 0.1 innings out of the bullpen. 

Prior to this series, the Nationals lost two out of three against the Guardians, but did win two out of three against the Reds before that. Washington has lost three games in a row and they are currently fourth in the NL East standings. The Washington pitching staff has a 5.47 ERA with a 1.46 WHIP and a .266 opponent batting average, while the offense has scored 168 runs with a .241 batting average and a .311 on base percentage this season. James Wood has led Washington with 10 home runs and 23 RBIs, while Nathaniel Lowe has added six home runs and 28 RBIs this year. The projected starting pitcher for Washington is Trevor Williams, who is 2-3 with a 5.86 ERA and a 1.61 WHIP over 35.1 innings pitched this season. 

Why the Nationals will beat the Cardinals 

• The Cardinals have lost each of their last seven day games against National League opponents following a road win.
• The Nationals have won nine of their last 10 Saturday games as underdogs against NL Central opponents.
• The Cardinals have failed to cover the run line in nine of their last 10 games as favorites against National League opponents following a road win.
• The Nationals have covered the run line in five of their last six games as underdogs against National League opponents following a home loss.

Why the Cardinals will beat the Nationals 

• The Cardinals have won each of their last six games against National League opponents.
• The Nationals have lost four of their last five games at Nationals Park.
• The Cardinals have covered the run line in each of their last six games against National League opponents.
• The Nationals have failed to cover the run line in four of their last five home games.
• The Cardinals have led after 3 innings in each of their last three road games against NL East opponents.
• The Cardinals have led after 5 innings in each of their last three games against the Nationals at Nationals Park.

Total Runs Facts

• Each of the Nationals’ last six games as home underdogs have gone OVER the total runs line.
• Seven of the Cardinals’ last eight games against NL East opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Nationals’ last four games as underdogs against NL Central opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Cardinals’ last six road games.

Washington Nationals Player Prop Facts

• Keibert Ruiz has hit a home run in three of his last five appearances against the Cardinals after playing the previous day.
• Trevor Williams has recorded a win in three of his last four appearances with the Nationals as home underdogs against NL opponents.
• Josh Bell has recorded at least one RBI in five of his last six appearances at Nationals Park against NL Central opponents that held a winning record.
• Nathaniel Lowe has scored a run in each of the Nationals’ last four day games.
• Trevor Williams has recorded four or more strikeouts in each of his last nine appearances at Nationals Park.
• Nathaniel Lowe has recorded at least one Single in each of his last five home appearances against NL Central opponents that held a winning record.
• CJ Abrams has recorded at least one hit in each of the Nationals’ last 11 games against NL opponents.

St. Louis Cardinals Player Prop Facts

• Willson Contreras has hit a home run in two of the Cardinals’ last three games against the Nationals.
• Willson Contreras has recorded at least one RBI in each of the Cardinals’ last four games as road favorites against NL East opponents.
• Masyn Winn has scored at least one run in each of his last six appearances with the Cardinals as road favorites against NL East opponents.
• Willson Contreras has recorded at least one Single in each of the Cardinals’ last six road games against NL East opponents.
• Nolan Arenado has recorded at least one hit in each of his last 10 Saturday day appearances against NL teams that held a losing record.

David Racey is 22-11 (67%) in the MLB over the last seven days. Click here for his premium plays for today!

Cardinals vs Nationals prediction 

St. Louis rolled to an easy win on Friday night in game one of this series and they have won six games in a row. The Cardinals are 5-13 on the road, while the Nationals are 10-10 at home. Washington has allowed 27 runs in their last three games and they are starting Williams, who has allowed nine earned runs and 14 hits over his last 10.2 innings. St. Louis is starting Pallante, who has allowed four earned runs in three of his last four starts. I think we are going to see plenty of runs in this game and I like the over here. 

David Racey's Pick: Over 9.5