St. Louis (78-81) vs Chicago (89-70)
September 26, 2025 at 02:20 PM EDT
The Line: Betting Odds: Chicago — Over/Under:
In this article we will formulate a Cardinals vs Cubs prediction for this MLB game on Friday, September 26th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 78-81 this year after they won two out of three against San Francisco by scores of 6-5, 9-8, and 3-4. In their game three loss, St. Louis led 2-1 in the third and tied the game at three in the eighth, but allowed a run in the bottom of the eighth for the loss. The Cardinals recorded seven hits and they committed three errors in the game, while they were led by Donovan, Herrera, and Arenado, who all had one RBI in the loss. St. Louis started Gray, who allowed seven hits and two earned runs over 6.0 innings, while O’Brien picked up the loss in relief.
Prior to that series, the Cardinals won two out of three against the Brewers, but lost two out of three against the Reds before that. St. Louis has won three of their last four games and they are fourth in the NL Central standings. The St. Louis pitching staff has a 4.23 ERA with a 1.32 WHIP and a .259 opponent batting average, while their offense has scored 685 runs with a .246 batting average and a .316 on base percentage this season. Wilson Contreras (IL) has led St. Louis with 20 home runs, 80 RBIs, and five stolen bases, while Alec Burleson has added 18 home runs and 69 RBIs this year. The projected starting pitcher for St. Louis is Miles Mikolas, who is 8-10 with a 4.76 ERA and a 1.33 WHIP over 151.1 innings pitched this year.
Chicago Cubs Betting Preview
The Chicago Cubs are 89-70 this season after they lost two out of three against the Mets by scores of 7-9, 10-3, and 5-8. In their game three loss, Chicago trailed 6-0 in the fourth inning and couldn’t overcome the deficit for the loss. The Cubs recorded seven hits in the game and they were led by Suzuki, who went 2-4 with two home runs and four RBIs in the loss. Chicago started Imanaga, who allowed nine hits and eight earned runs over 5.2 innings for the loss, while three pitchers finished the last 3.1 innings in relief.
Prior to that series, the Cubs lost all four against the Reds, but did win all three against the Pirates before that. Chicago has lost six of their last seven games and they are second in the NL Central standings. The Chicago pitching staff has a 3.84 ERA with a 1.18 WHIP and a .240 opponent batting average, while their offense has scored 772 runs with a .249 batting average and a .320 on base percentage this season. Seiya Suzuki has led Chicago with 29 home runs and 97 RBIs, while Pete Crow-Armstrong has added 29 home runs and 91 RBIs this year. The projected starting pitcher for Chicago is TBD.
Why the Cardinals will beat the Cubs
The Cardinals have won each of their last four games against NL Central opponents following a loss.
The Cubs have lost six of their last seven games.
The Cardinals have covered the run line in seven of their last eight games against National League opponents following a loss.
The Cubs have failed to cover the run line in seven of their last eight home games against National League opponents after playing the previous day.
Total Runs Facts
Six of the Cubs’ last seven home games have gone OVER the total runs line.
Five of the Cardinals’ last six day games against National League opponents have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the last five games between the Cardinals and Cubs at Wrigley Field.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Cardinals’ last five day games.
Chicago Cubs Player Prop Facts
Ian Happ has hit a home run in three of the Cubs’ last four day games against opponents that held a losing record.
Ian Happ has recorded a Double in each of the Cubs’ last three home games.
Nico Hoerner has recorded at least one hit in each of his last 10 appearances in day games against teams that held a losing record.
St. Louis Cardinals Player Prop Facts
Lars Nootbaar has hit at least one home run in three of his last eight appearances against the Cubs after not playing the previous day.
Brendan Donovan has recorded at least one Double in four of his last five appearances against NL opponents.
Alec Burleson has recorded at least one hit in each of the Cardinals’ last nine games against NL opponents.
Miles Mikolas has recorded three or more strikeouts in each of his last 12 appearances in day games against NL teams that held a winning record.
Matchup/League Facts
The Cubs rank 4th in the league for RBIs this season (750).
The Cubs are one of only four teams in the league to rank top 10 in both steals and home runs this season.
The Cardinals rank 29th in the league for strikeouts this season (1185).
The Cardinals rank 27th in the league for slugging percentage this season (.380).
Cardinals vs Cubs Prediction
Chicago comes into this matchup very close to locking in the first wild card spot in the NL, but they have not played very well over the last weeks. The Cubs are 47-31 at home this year, while the Cardinals are 34-44 on the road. St. Louis has won three of their last four games and they are starting Mikolas, who has allowed two earned runs or fewer in five straight starts. Chicago has not announced their starting pitcher for this one, but I like how Mikolas has looked and the Cardinals are hitting the ball. Take St. Louis here.