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Boston Red Sox vs Toronto Blue Jays Prediction 9/23/2025 Today’s MLB Picks

Sep 20, 2025; Kansas City, Missouri, USA; Toronto Blue Jays first base Vladimir Guerrero Jr. (27) reacts to a play during the fourth inning against the Kansas City Royals at Kauffman Stadium. Mandatory Credit: William Purnell-Imagn Images

Sep 20, 2025; Kansas City, Missouri, USA; Toronto Blue Jays first base Vladimir Guerrero Jr. (27) reacts to a play during the fourth inning against the Kansas City Royals at Kauffman Stadium. Mandatory Credit: William Purnell-Imagn Images

Boston (85-71) vs Toronto (90-66)

September 23, 2025 at 07:07 PM EDT

The Line: Betting Odds: Toronto -165 — Over/Under: +8

(Get latest betting odds)

The Boston Red Sox and the Toronto Blue Jays meet Tuesday in MLB action from Rogers Centre. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Boston Red Sox vs. Toronto Blue Jays prediction.

Starting Pitching Matchup

The Boston Red Sox will send out Lucas Giolito here and Giolito is 10-4 with a 3.46 ERA and 118 strikeouts this season. In his last five starts against the Blue Jays, Giolito is 1-2 with a 4.60 ERA and 24 strikeouts. Kevin Gausman will get the start for the Blue Jays and is 10-10 with a 3.38 ERA and 177 strikeouts this season. In his last five starts against Boston, Gausman is 2-1 with a 2.93 ERA and 29 strikeouts. 

Boston Red Sox Recap

The Boston Red Sox come into this game looking to rebound from a 7-3 loss at the hands of the Tampa Bay Rays last time out to sit at 85-71 this season. After this series, the Red Sox will head home for a series against the Detroit Tigers.

Red Sox In Midst Of Final Playoff Push

Alex Bregman has 116 hits including 27 doubles along with 18 home runs and 62 RBIs this season. Trevor Story’s added 156 hits with 25 home runs, 95 RBIs and 31 stolen bases while Jarren Duran has 156 hits with 39 doubles, 13 triples, 16 home runs, 82 RBIs and a team-high 24 stolen bases. Roman Anthony’s added 75 hits with 18 doubles, 8 home runs and 32 RBIs while Wilyer Abreu has 22 home runs with 69 RBIs and 6 stolen bases and Ceddanne Rafaela has 16 homers, 31 doubles, 3 triples, 62 RBIs and 19 stolen bases this season.

Toronto Blue Jays Recap

The Toronto Blue Jays come into this game looking to add on to their 8-5 win over the Kansas City Royals last time out to sit at 90-66 this season. After this series, the Blue Jays will take on the Tampa Bay Rays in a series at home.

Blue Jays Snap Four-Game Skid

George Springer has 145 hits and Bo Bichette has 181 hits with Springer adding 30 home runs, a triple, 25 doubles and 80 RBIs while Bichette has 44 doubles, 18 home runs and 94 RBIs. Andres Gimenez has added 66 hits with 9 doubles and 7 home runs and 32 RBIs this season along with 12 stolen bases. Vladimir Guerrero Jr. also has 23 homers, 34 doubles and 83 RBIs while Springer also has a .305 batting average and 106 strikeouts up to this point in the year. Addison Barger’s chipped in 31 doubles with 20 home runs and 73 RBIs and Ernie Clement’s added 33 doubles as part of his 146 hits this season.

Boston Red Sox @ Toronto Blue Jays Betting Trends: September 23, 2025

  • Probable Starting Pitcher: Kevin Gausman      Record this season: 10-10      ERA: 3.38
  • Home Record: 5-4
  • Last 5 against Red Sox: 2-1

Why the Toronto Blue Jays will win

  • The Blue Jays have won nine of their last 10 home games against AL East opponents.
  • The Red Sox have lost seven of their last eight night games against the Blue Jays following a loss.
  • The Blue Jays have covered the run line in eight of their last nine home games against AL East opponents that held a winning record.
  • The Red Sox have failed to cover the run line in seven of their last eight night games against the Blue Jays following a loss.
  • The Red Sox have lost the first inning in three of their last four games.
  • The Blue Jays have led after 5 innings in five of their last six home games against AL East opponents that held a winning record.
  • The Red Sox have trailed after 3 innings in three of their last four games.
  • Probable Starting Pitcher: Lucas Giolito      Record this season: 10-4      ERA: 3.46
  • Road Record: 5-2
  • Last 5 against Blue Jays: 1-2

Why the Boston Red Sox will win

  • The underdogs have won each of the last five games between the Red Sox and Blue Jays.
  • The Blue Jays have lost each of their last five games as favorites against AL East opponents following a road win.
  • The Blue Jays have failed to cover the run line in each of their last 11 Tuesday games as favorites against AL East opponents.
  • The Red Sox have covered the run line in 11 of their last 12 games as road underdogs against AL East opponents following a road loss.
  • The Red Sox have led after 3 innings in each of their last eight Tuesday games.
  • The Red Sox have led after 5 innings in each of their last three games at Rogers Centre.

Total Runs Facts

  • Each of the Red Sox’s last four games against AL East opponents have gone OVER the total runs line.
  • Five of the Blue Jays’ last six night games against AL East opponents have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Blue Jays’ last eight Tuesday games at Rogers Centre.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Red Sox’s last eight games against AL East opponents.

Toronto Blue Jays Player Prop Facts

  • Daulton Varsho has hit a home run in each of his last two appearances against the Red Sox.
  • Kevin Gausman has recorded six or more strikeouts in each of his last four appearances with the Blue Jays as favorites.
  • Kevin Gausman has recorded a win in each of his last five appearances in night games against AL East teams that held a winning record.
  • Bo Bichette has recorded a Double in each of his last five appearances against AL opponents that held a winning record.
  • Bo Bichette has recorded at least one hit in each of his last 21 appearances with the Blue Jays as home favorites against AL opponents.

Boston Red Sox Player Prop Facts

  • Jarren Duran has hit a home run in three of his last four appearances against the Blue Jays after not playing the previous day.
  • Lucas Giolito has recorded five or more strikeouts in nine of his last 10 road appearances against AL opponents that held a winning record.
  • Jarren Duran has recorded at least one hit in each of his last 10 road appearances against the Blue Jays.
  • Lucas Giolito has recorded a win in four of his last five road appearances against AL opponents.

Boston Red Sox vs. Toronto Blue Jays Prediction

I’m on the Blue Jays here. I just think that the Blue Jays have the edge in starting pitching for this matchup because as profitable as Lucas Giolito’s been at times this year, he’s still had issues with consistency. Toronto needs a win to get closer to the division title, and Kevin Gausman’s been a really strong option for this Blue Jays rotation in his recent outings. I’ll side with Toronto.

Chris Ruffolo's Pick: Toronto -165

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