Blue Jays vs Orioles Prediction 9/21/2026 Today’s MLB Picks

In this article we will formulate a Blue Jays vs Orioles prediction for this MLB game on Monday, September 21st at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 77-79 this year after they lost two out of three against the Rangers by scores of 1-7, 2-6, and 7-2. In game three, Toronto blew a 2-0 lead in the fourth inning, but they scored the last five runs for the win. The Blue Jays recorded 11 hits in the game and they were led by Lukes, who went 2-3 with two RBIs. Miles allowed two hits over 3.0 innings as the opener, while Arrighetti picked up the win in relief. Prior to that series, Toronto lost two out of three against the Tigers, but did win two out of three against the Orioles before that. 

This season, Toronto has a 3.91 ERA with a 1.30 WHIP and a .236 opponent batting average, while they have scored 629 runs with a .248 batting average and a .311 on base percentage. Kazuma Okamoto has led the Blue Jays with 33 home runs and 89 RBIs, while Andres Gimenez has added nine home runs and 58 RBIs. The projected starting pitcher for Toronto is Trey Yesavage, who is 5-5 with a 3.65 ERA and a 1.14 WHIP over 93.2 innings pitched this year. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 75-81 this season after they lost all three against the Brewers by scores of 5-6, 0-1, and 0-3. In game three, Baltimore fell behind in the second inning and never found any offense in the shutout loss. The Orioles recorded four hits and they were led by Cowser, who went 2-4 in the game. Young allowed three hits and two earned runs over 6.0 innings for the loss, while Bautista allowed one earned run in relief. Prior to that series, Baltimore swept the Mets in three games, but lost two out of three against the Blue Jays before that. 

This season, Baltimore has a 4.12 ERA with a 1.34 WHIP and a .253 opponent batting average, while they have scored 693 runs with a .234 batting average and a .314 on base percentage. Pete Alonso has led the Orioles with 38 home runs and 105 RBIs, while Gunnar Henderson has added 23 home runs and 58 RBIs. The projected starting pitcher for Baltimore is Shane Baz, who is 6-15 with a 4.11 ERA and a 1.35 WHIP over 173.0 innings pitched this season. 

Why the Baltimore Orioles will win

• The Blue Jays have lost each of their last five night games against AL opponents.
• The Orioles have won each of their last four night games against teams that held a losing record.
• The Blue Jays have failed to cover the run line in each of their last five night games against AL opponents.
• The Orioles have covered the run line in each of their last four games as favorites against AL opponents following a home loss.
• The Blue Jays have trailed after 5 innings in four of their last five road games against AL opponents that held a losing record.
• The Blue Jays have trailed after 3 innings in four of their last five road games against opponents that held a losing record.

Why the Toronto Blue Jays will win

• The underdogs have won five of the Blue Jays’ last six games at Oriole Park at Camden Yards.
• The Orioles have lost four of their last five games as favorites after playing the previous day.
• The road team has covered the run line in five of the Orioles’ last six games.
• The Orioles have failed to cover the run line in five of their last six games as favorites after playing the previous day.
• The Orioles have trailed after 3 innings in three of their last four games against AL opponents that held a losing record.

Total Runs Facts

• Each of the Orioles’ last six games against AL opponents have gone OVER the total runs line.
• Eight of the Blue Jays’ last nine games against AL opponents have gone OVER the total runs line.
• There has been no run scored during the first inning in each of the Blue Jays’ last four night games at Oriole Park at Camden Yards.
• There has been no run scored during the first inning in six of the Orioles’ last seven games as home favorites against AL East opponents.

Baltimore Orioles Player Prop Facts

• Coby Mayo has hit a home run in three of the Orioles’ last four night games against AL East opponents that held a losing record.
• Samuel Basallo has recorded at least one hit in each of his last six appearances at Oriole Park at Camden Yards against opponents that held a losing record.
• Shane Baz has recorded five or more strikeouts in six of his seven previous home appearances against AL opponents that held a losing record.

Toronto Blue Jays Player Prop Facts

• Kazuma Okamoto has hit a home run in four of the Blue Jays’ last six night games against AL opponents that held a losing record.
• Kazuma Okamoto has recorded at least one hit in each of his last 13 appearances with the Blue Jays as underdogs.
• Trey Yesavage has recorded six or more strikeouts in six of his last seven appearances with the Blue Jays as underdogs against AL opponents.

Matchup/League Facts

• The Orioles rank 26th in the league for hits this season (1218).
• The Orioles rank 5th in the league for walks this season (569).
• The Blue Jays rank T29th in the league for RBIs this season (598).
• The Blue Jays rank 2nd in the league for strikeouts against this season (1111).

Blue Jays vs Orioles Prediction

Baltimore comes into this matchup after getting swept by the Brewers and they haven’t scored a run since Friday night. The Orioles are 36-42 at home this year, while the Blue Jays are 37-41 on the road. Toronto has split their last four games, but they have scored two runs or fewer in three of their last five. The Blue Jays are starting Yesavage, who has been on the IL since early August, while Baz has allowed eight earned runs in his last 9.2 innings. Take the over here.

David Racey's Pick: Over 7.5