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Baltimore Orioles vs Washington Nationals Prediction 4/24/25 MLB Picks

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Washington Nationals (10-13) vs Baltimore Orioles (9-13)

Game Info: Thursday, April 24, 2025 at 6:45 pm (Nationals Park)

The Line: Betting Odds: Washington Nationals -115 / Baltimore Orioles -105 — Over/Under: 9

(Get latest betting odds)

The Baltimore Orioles and the Washington Nationals meet Thursday in MLB action from Nationals Park. This will be the finale in a three-game series. Here’s an Orioles vs Nationals prediction. We will look at this from a betting perspective and determine the best Orioles vs Nationals pick. We will examine: 

The Baltimore Orioles’ recent form and player performance

The Washington Nationals’ recent form and player performance 

Recent betting trends and streaks involving the Baltimore Orioles

Recent betting trends and streaks involving the Washington Nationals

Recent betting trends in games played between the Orioles and Nationals

A summary that ties it all together and produces a favorable betting outcome for the Orioles vs Nationals game

Baltimore Orioles Betting Preview

Baltimore posted a four-game split with the Toronto Blue Jays in their opening series this year, then fell in a set against the Boston Red Sox. The Orioles would lose their next two series versus the Kansas City Royals and Arizona Diamondbacks, then split a pair against the Blue Jays. After a series win over the Cleveland Guardians, Baltimore lost in two of three versus the Reds over the weekend. On Tuesday in the opener versus the Nationals, the O’s were only able to notch one hit in a rough loss, 7-0. Cedric Mullins had the lone knock, adding a pair of walks as well. 

In the Wednesday matchup, Baltimore gave up three runs in the first inning along the way to a 4-3 loss. The O’s out-hit the Nats 10-6 but still fell. Starting pitcher Tomoyuki Sugano lasted 7.0 innings with three earned runs on five hits. 

As the starting pitcher for the Thursday finale, the Orioles will roll with Cade Povich. So far, over four starts, Povich is 0-2 with a 6.38 ERA in 18.1 innings total. Povich is 3-11 with a 5.42 ERA in 20 career starts. 

Washington Nationals Betting Preview

Over on the Nationals’ side, they lost their first two series versus the Philadelphia Phillies and Toronto Blue Jays (sweep) before winning two of three versus the Arizona Diamondbacks. Washington would win another set versus the Los Angeles Dodgers, ahead of losses in two of three versus the Marlins and in three of four against the Pirates. Over the weekend, Washington won their first pair over the Rockies before a 3-1 Sunday loss. In the Tuesday opener versus the O’s, Washington cruised on 14 team hits. Starter Mitchell Parker was great with 8.0 innings, one hit, two walks, and four strikeouts on the card. 

On Wednesday, the Nationals got home runs from James Wood (solo) and Josh Bell (two RBI) in their tight win. Starting pitcher Trevor Williams put up 5.0 innings with one earned run on six hits and a walk. Williams struck out five along the way. 

For Thursday’s finale, the Nats will send out MacKenzie Gore in the starting role. Gore is 2-2 with a 3.41 ERA in five total starts this year, totaling 29.0 innings. Gore is 23-28 with a 4.15 ERA in 80 career games (77 starts). 

Why the Washington Nationals will win

Why the Baltimore Orioles will win

Total Runs Facts

Orioles vs Nationals Prediction 

I’ll lean toward the Nats. You could probably call this one either way, though. Gore had a spotty start in a loss versus Miami on April 13, notching 6.0 innings with four earned on eight hits and three walks. In the other two of his most recent trio, however, Gore is a combined 2-0 with just four earned in 12.0 innings on nine hits and three walks. As for Povich, he’s coming off a rough loss to the Reds with seven earned runs in 3.1 innings. In his 10.2 prior frames over two starts, however, Povich gave up just three earned runs. 

Washington started out great in their Wednesday win, but fizzled a bit the rest of the way. The pitching was spotty here and there, but overall held things together. I’d like to see a better effort on Thursday, but it’s a coin flip. 

Andrew Jett's Pick: Washington Nationals -115

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