Baltimore Orioles vs Seattle Mariners Prediction 6/4/25 MLB Picks

The Baltimore Orioles are visiting the Seattle Mariners on Wednesday, June 4th at the T-Mobile Park in the second game of this series, with the Orioles having a 1-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s the Baltimore Orioles vs Seattle Mariners Prediction. We will examine:

The Seattle Mariners’ recent form and player performance

The Baltimore Orioles’ recent form and player performance

Recent betting trends and streaks involving the Seattle Mariners

Recent betting trends and streaks involving the Baltimore Orioles

Recent betting trends in games played between the Baltimore Orioles vs the Seattle Mariners

A summary that ties it all together and produces a favorable betting outcome for the Baltimore Orioles vs Seattle Mariners game

Seattle Mariners Preview

The Seattle Mariners have a 32-27 record this season and are sitting in second place in the AL West. The Mariners have a 16-15 home record and 32-25 in over/under. They are coming off a 1-5 home defeat by the Orioles, and saw their two-game winning streak get snapped. Over is 5-2 in their last 7 games, and they are playing the Diamondbacks and the Angels next.

The Mariners have a .236 batting average this season, a .320 OBP, and a .395 Slugging percentage. Seattle’s pitching staff has a 3.88 ERA and 1.33 WHIP. Julio Rodriguez leads the Mariners in hits with 58, while Cal Raleigh leads the team both in RBI with 45 and in home runs with 23. J.P. Crawford is the team’s best hitter with a .281 batting average.

Emerson Hancock (R) will take the mound for the Mariners, and he has a 2-2 record, 5.64 ERA, and 1.57 WHIP. He has been terrible at home, with a 9.53 ERA across four home starts, and he has given up 5 runs across 11.1 innings pitched in his last two starts. This will be his first career start against the Orioles.

Baltimore Orioles Preview

The Baltimore Orioles have a 23-36 record this season and are sitting in last place in the AL East. The Orioles have an 11-19 road record and 28-28 in over/under. They are coming off a 5-1 road victory over the Mariners, and are 7-2 in their last 9 games. Under is 4-0 in their last 4 games, and they are playing the Athletics and the Tigers next.

The Orioles have a .239 batting average this season, a .303 OBP, and a .387 slugging percentage. Baltimore’s pitching staff has a 5.19 ERA and 1.45 WHIP.  Ryan O’Hearn leads the Orioles with 58 hits, and he is the team’s best hitter with a .3235 batting average. Cedric Mullins leads the team in RBI, with 31, and in home runs, with 10.

Cade Povich (R) will take the mound for the Orioles, and he has a 1-4 record, 5.29 ERA, and 1.53 WHIP. He has been better on the road, with a 3.04 ERA across four road starts, but he was torched in his last start, with 5 earned runs in 4.1 innings pitched against the Cardinals. This will be his first career start against the Mariners.  

Why the Seattle Mariners will win

• The Orioles have lost eight of their last nine games against American League opponents following a road win.
• The Mariners have won seven of their last eight Wednesday games against American League opponents.
• The Orioles have failed to cover the run line in seven of their last eight night games against the Mariners following a road win.
• The Mariners have covered the run line in each of their last six Wednesday home games against American League opponents.
• The Orioles have trailed after 3 innings in nine of their last 12 road night games.

Why the Baltimore Orioles will win

• The underdogs have won each of the Orioles’ last six games at T-Mobile Park.
• The Mariners have lost each of their last four games as favorites against AL East opponents.
• The Mariners have failed to cover the run line in each of their last nine games as favorites after playing the previous day.
• The underdogs have covered the run line in 12 of the Mariners’ last 13 games.
• The Orioles have led after 3 innings in each of their last five Wednesday games against opponents that held a winning record.
• The Orioles have led after 5 innings in each of their last five night games against the Mariners.

Total Runs Facts

• Each of the Orioles’ last six games against American League opponents have gone UNDER the total runs line.
• Twelve of the Mariners’ last 14 games as home favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Orioles’ last four games against AL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Mariners’ last seven games as favorites against American League opponents.

Matchup/League Facts

• The Mariners rank T29th in the league for doubles this season (71).
• The Mariners are one of only three teams in the league to rank top 10 in both steals and home runs this season.
• The Orioles rank 29th in the league for home runs allowed this season (89).
• The Orioles rank 28th in the league for ERA this season (5.19).

Baltimore Orioles vs Seattle Mariners Prediction

The Orioles are 7-2 in their last 9 meetings against the Mariners, and 5-2 in their last 7 visits to Seattle. Under is 4-1 in their last 5 meetings in Seattle.

In this Baltimore Orioles vs Seattle Mariners Prediction, the Mariners are coming as -130 home favorites. The Mariners are rightfully favored, as they have a far better overall record, while the Orioles have been terrible on the road. I don’t trust any starting pitcher in this matchup, as they have a combined 10.95 ERA and 1.50+ WHIP. With the Orioles being better against righties with 4.3 runs per game, while having the 4th-worst bullpen ERA in the league, with 5.28, I expect a lot of runs in this game. Take the Over 8.5.  

Nikos Lagouretos's Pick: Over 8.5