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Baltimore Orioles vs San Diego Padres Prediction 9/1/2025 Today’s MLB Picks

Aug 31, 2025; Minneapolis, Minnesota, USA; San Diego Padres relief pitcher Yuki Matsui (1) awaits pitching coach Ruben Niebla in the seventh inning of the game with the Minnesota Twins at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

Aug 31, 2025; Minneapolis, Minnesota, USA; San Diego Padres relief pitcher Yuki Matsui (1) awaits pitching coach Ruben Niebla in the seventh inning of the game with the Minnesota Twins at Target Field. Mandatory Credit: Bruce Kluckhohn-Imagn Images

Baltimore (61-76) vs San Diego (76-61)

September 1, 2025 at 06:40 PM EDT

The Line: Betting Odds: San Diego -1.5 — Over/Under: +7.5

(Get latest betting odds)

The Baltimore Orioles and San Diego Padres meet Monday in MLB action at Petco Park. Here’s a Baltimore Orioles vs San Diego Padres Prediction. This article will include a Baltimore Orioles vs San Diego Padres Pick.

Baltimore Orioles Betting Preview


The Baltimore Orioles are 61-76 on the year and play the Dodgers, Pirates, and Blue Jays next. The Baltimore Orioles are batting .242 on the season, have a .307 OBP, and a .405 slugging percentage. The Baltimore Orioles pitching staff has a 4.73 ERA and a 1.38 WHIP. Gunnar Henderson leads the Baltimore Orioles with 137 hits and 61 RBI, while Jackson Holliday and Jordan Westburg have combined for 202 hits and 85 RBI.

Kyle Bradish gets the ball for the Baltimore Orioles, and he is 0-1 with a 3.00 ERA and 10 strikeouts this season. This will be Bradish’s first career game against the San Diego Padres.

San Diego Padres Betting Preview


The San Diego Padres are 76-61 on the year and play the Rockies, Reds, and Rockies next. The San Diego Padres are batting .252 on the season, have a .322 OBP, and a .386 slugging percentage. The San Diego Padres pitching staff has a 3.63 ERA and a 1.20 WHIP. Manny Machado leads the San Diego Padres with 151 hits and 79 RBI while Luis Arraez and Fernando Tatis Jr. have combined for 285 hits and 106 RBI.

Dylan Cease gets the ball for the San Diego Padres, and he is 6-11 with a 4.82 ERA and 183 strikeouts this season. Cease is 3-1 with a 3.82 ERA and 45 strikeouts in his career against the Baltimore Orioles.

Baltimore Orioles vs San Diego Padres Prediction


The Orioles look like a team that’s ready for the offseason, as they’ve won just two games since August 21. Bradish has just six innings under his belt this season, which makes them even less attractive. The Padres need to take advantage of games like this if they’re going to give the Dodgers a push for the NL West crown. Cease has been up and down, but he’s respectable at home, where he has a 3.86 ERA and .221 allowed batting average. No excuses for the Padres. Give me the home team and the RL for max betting value.

Randy Chambers's Pick: San Diego Padres

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